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Clinical utility of current biomarkers for prostate cancer detection

Kim JH, Hong SK

Although prostate-specific antigen (PSA) remains the most used test to detect prostate cancer (PCa), the limited specificity and an elevated rate of overdiagnosis are the main problems associated with PSA...
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Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19

Song KH, Kim DM, Lee H, Ham SY, Oh SM, Jeong H, Jung J, Kang CK, Park JY, Kang YM, Kim JY, Park JS, Park KU, Kim ES, Kim HB

Recently, the number of patients with coronavirus disease 2019 (COVID-19) who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), via the reverse transcription polymerase chain reaction (RT-PCR)...
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Diabetes Mellitus and COVID-19

Park JH

Diabetes mellitus is known to be associated with more severe outcomes and increased mortality in patients presenting with coronavirus disease 2019 (COVID-19; severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2]) infection. The...
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COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis

Sohn KM, Lee SG, Kim HJ, Cheon S, Jeong H, Lee J, Kim IS, Silwal P, Kim YJ, Paik S, Chung C, Park C, Kim YS, Jo EK

Background: Observational studies of the ongoing coronavirus disease 2019 (COVID-19) outbreak suggest that a ‘cytokine storm’ is involved in the pathogenesis of severe illness. However, the molecular mechanisms underlying the altered...
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The Effects of Nurses’ Knowledge of Withdrawal of LifeSustaining Treatment, Death Anxiety, Perceptions of Hospice on Their Attitudes toward Withdrawal of Life-Sustaining Treatment

Lee YE, Jung YJ, Jang YN, Jeong HE

Purpose: This descriptive study investigated the effects of nurses’ knowledge of withdrawal of life-sustaining treatment, death anxiety, and perceptions of hospice care on their attitudes toward withdrawal of life-sustaining treatment. Methods:...
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KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure

Lee JH, Seo HW, Ryu JY, Lim CJ, Yi KY, Oh KS, Lee BH

G protein-coupled receptor kinase 5 (GRK5) has been considered as a potential target for the treatment of heart failure as it has been reported to be an important regulator of...
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Beneficial Effect of Chloroquine and Amodiaquine on Type 1 Diabetic Tubulopathy by Attenuating Mitochondrial Nox4 and Endoplasmic Reticulum Stress

Kang JM, Lee HS, Kim J, Yang DH, Jeong HY, Lee YH, Kim DJ, Park SH, Sung M, Kim J, An HJ, Lee SH, Lee SY

Background: Oxidative stress induced by chronic hyperglycemia is recognized as a significant mechanistic contributor to the development of diabetic kidney disease (DKD). Nonphagocytic nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) is...
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Renal intravascular large B cell lymphoma: the first case report in Korea and a review of the literature

Kim M, Chung H, Yang WI, Jeong HJ

Herein, we describe the first case of renal intravascular large B cell lymphoma in Korea occurring in a 66-year-old female. She presented with mild fever and dyspnea. On physical and...
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Medial Temporal Atrophy Alone is Insufficient to Predict Underlying Alzheimer’s Disease Pathology

Jeong HE, Shin DH, Lee DC

Background: The medial temporal region is the earliest affected structure in patients with Alzheimer’s disease (AD), and its atrophy is known as the hallmark of AD. This study aimed to...
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Potential Utility of Prostate Health Index Density for Prostate Cancer Detection and Prediction in Korean Men: A Prospective Multicenter Study

Song G, Park H, Lee SW, Kang TW, Jung JH, Chung HC, Kim SJ, Park JY, Kim JH

Purpose: We evaluated the clinical performance of Prostate Health Index (PHI) density with [-2]proPSA (p2PSA)and its derivatives in predicting the presence of prostate cancer (PCa) in Korean men. Materials and Methods:...
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Management of Patients With Advanced Prostate Cancer: Establishment ofTreatment Guidelines Through Prostate Cancer Summit (PCAS) 2016Composed of Korean Prostate Cancer Experts

Jang CT, Kim HJ, Kim MK, Park SW, Park SC, Park JY, Lee DH, Lee SH, Jeon HG, Chung JH, Jeong H, Jo MK, Hong SH, Kwak C, Lee JY, Kwon DD, Kim CS, Jeon SS

Purpose: The Advanced Prostate Cancer Consensus Conference (APCCC) 2015 was based on topics withcontroversy in the field of advanced prostate cancer. To understand the Korean urologists perspective regardingthe issues, we...
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Morin Hydrate Inhibits Influenza Virus entry into Host Cells and Has Anti-inflammatory Effect in Influenzainfected Mice

Hong EH, Song aH, Kim SR, Cho J, Jeong B, Yang H, Jeong JH, Ahn JH, Jeong H, Kim SE, Chang SY, Ko HJ

Influenza virus is the major cause of seasonal and pandemic flu. Currently, oseltamivir, a potent and selective inhibitor of neuraminidase of influenza A and B viruses, is the drug of...
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Adjuvanticity of Processed Aloe vera gel for Influenza Vaccination in Mice

Song EJ, Españo E, Nam JH, Kim J, Shim KS, Shin E, Park YI, Lee CK, Kim JK

The effectiveness of current influenza vaccines is considered suboptimal, and 1 way to improve the vaccines is using adjuvants. However, the current pool of adjuvants used in influenza vaccination is...
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Diagnostic Usefulness of an Ultra-Brief Screener to Identify Risk of Online Gaming Disorder for Children and Adolescents

Jo SJ, Jeong H, Son HJ, Lee HK, Lee SY, Kweon YS, Yim HW

Objective This study examined the diagnostic validity of a three-item ultra-brief screening tool for online gaming disorder in line with the gaming disorder criteria in the International Classification of Diseases...
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Clinical Course and Outcomes of 3,060 Patients with Coronavirus Disease 2019 in Korea, January–May 2020

Sung HK, Kim JY, Heo J, Seo H, Jang Ys, Kim H, Koh BR, Jo N, Oh HS, Baek YM, Park KH, Shon JA, Kim MC, Kim JH, Chang HH, Park Y, Kang YM, Lee DH, Oh DH, Park HJ, Song KH, Lee EK, Jeong H, Lee JY, Ko JY, Choi J, Ryu EH, Chung Kh, Oh Md, The Korea National Committee for Clinical Management of COVID-19

Background: The fatality rate of patients with coronavirus disease 2019 (COVID-19) varies among countries owing to demographics, patient comorbidities, surge capacity of healthcare systems, and the quality of medical care....
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Reversible Cerebral Vasoconstriction Syndrome Combined with Posterior Encephalopathy Syndrome, and Transient Splenial Lesion after Delivery

Seo HS, Lee WK, Shin JW, Jeong HS

The postpartum period is generally considered to be increased risk of various cerebral disorders, such as reversible cerebral vasoconstriction syndrome (RCVS), posterior reversible encephalopathy syndrome (PRES), and eclampsia. They manifest...
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Driving-Related Adverse Events in the Elderly Men: A Population-Based Prospective Cohort Study

Kim JS, Bae JB, Han K, Hong JW, Han JH, Kim TH, Kwak KP, Kim K, Kim BJ, Kim SG, Kim JL, Kim TH, Moon SW, Park JY, Park JH, Byun S, Suh SW, Seo JY, So Y, Ryu SH, Youn JC, Lee KH, Lee DY, Lee DW, Lee SB, Lee JJ, Lee JR, Jeong H, Jeong HG, Jhoo JH, Han JW, Kim KW

Objective This study estimated the incidence of driving-related adverse events and examined the association of cognitive function with the risk of future driving-related adverse events in the elderly Korean male...
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Comparison of 3-Dimensional Pelvic Floor Ultrasonography and Defecography for Assessment of Posterior Pelvic Floor Disorders

Jeong HY, Yang SJ, Cho DH, Park DH, Lee JK

Purpose: The aim of this study was to determine the accuracy of 3-dimensional (3D) pelvic floor ultrasonography and compare it with defecography in assessment of posterior pelvic disorders. Methods: Eligible patients...
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Three cases of oral immunotherapy for IgE-mediated egg allergy

Kim I, Lee BR, Kyung Y, Jung M, Yang HK, Kim M, Lee JY, Kim J, Ahn K, Jeong HI

Food allergy is an immune-mediated adverse reaction that occurs mainly by food ingestion. Some children with food allergies manifest fatal symptoms like anaphylaxis. Oral immunotherapy (OIT) may offer an effective...
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Acute Kidney Injury and Kidney Damage in COVID-19 Patients

Na KR, Kim HR, Ham Y, Choi DE, Lee KW, Moon JY, Kim YS, Cheon S, Sohn KM, Kim J, Kim S, Jeong H, Jeon JW

Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This disease, which is quickly spreading worldwide, has high potential for infection and causes...
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