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Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice

Park KA, Jin Z, An HS, Lee JY, Jeong EA, Choi EB, Kim KE, Shin HJ, Lee JE, Roh GS

Obesity causes inflammation and impairs thermogenic functions in brown adipose tissue (BAT). The adipokine lipocalin 2 (LCN2) has been implicated in inflammation and obesity. Herein, we investigated the protective effects...
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Atorvastatin pretreatment attenuates kainic acid-induced hippocampal neuronal death via regulation of lipocalin-2-associated neuroinflammation

Jin Z, Jung Y, Yi CO, Lee JY, Jeong EA, Lee JE, Park KJ, Kwon OY, Lim BH, Choi NC, Roh GS

Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism...
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Cilostazol attenuates kainic acid-induced hippocampal cell death

Park YS, Jin Z, Jeong EA, Yi CO, Lee JY, Park IS, Roh GS

Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate...
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Endovascular Treatment for Acute Ischemic Stroke Patients over 80 Years of Age

Hwang K, Hwang G, Kwon OK, Kim CH, Ban SP, Han MK, Bae HJ, Kim BJ, Bang JS, Oh CW, Lee B, Jeong EA

OBJECTIVE: We evaluated the effect of endovascular treatment (EVT) for acute ischemic stroke in patients over 80 years of age. MATERIALS AND METHODS: The records of 156 acute stroke patients aged...
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Pak1/LIMK1/Cofilin Pathway Contributes to Tumor Migration and Invasion in Human Non-Small Cell Lung Carcinomas and Cell Lines

Jang I, Jeon BT, Jeong EA, Kim EJ, Kang D, Lee JS, Jeong BG, Kim JH, Choi BH, Lee JE, Kim JW, Choi JY, Roh GS

Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung carcinoma (NSCLC). Although both SCCs and ACs have been characterized histologically and clinically, the...
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Resveratrol activates AMPK and suppresses LPS-induced NF-kappaB-dependent COX-2 activation in RAW 264.7 macrophage cells

Yi CO, Jeon BT, Shin HJ, Jeong EA, Chang KC, Lee JE, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS

AMP-activated protein kinase (AMPK), an enzyme involved in energy homeostasis, regulates inflammatory responses, but its precise mechanisms are not fully understood. Recent evidence has shown that resveratrol (RES), an AMPK...
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Phosphorylation of 14-3-3zeta at serine 58 and neurodegeneration following kainic acid-induced excitotoxicity

Jeong EA, Jeon BT, Kim JB, Kim JS, Cho YW, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS

Oxidative stress-induced cell death leads to phosphorylation of 14-3-3zeta at serine 58. 14-3-3zeta is detected at significant levels in cerebrospinal fluid after kainic acid (KA)-induced seizures. Here we examined temporal...
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Predictors of Successful Percutaneous Transluminal Coronary Angioplasty in Multivessel Disease

Jeong MH, Cho IJ, Lee MK, Park JS, Ahn YK, Park JH, Jeong EA, Cho JG, Park JC, Kang JC

BACKGROUND: Percutaneous transluminal coronary angioplasty (PTCA) was initially applied in patients with proximal, discrete, single vessel disease, but complex multivessel PTCA has become feasible with increased operator experience and instrumental...
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The Clinical Effects of Perindopril(Acertil(R)) on Hypertensive Patients

Jeong MH, Suh JP, Lee MK, Park JS, Ahn YK, Park JH, Jeong EA, Cho JG, Park JC, Kang JC, Park YG, Kang YJ

BACKGROUND: Perindopril. a new second-generation angiotensin converting enzyme inhibitor developed by Servier Research, was administered in essential hypertensive patients in order to observe the clinical effects. METHOD: The changes of...
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