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Lung Disease Diagnostic Model Through IgG Sensitization to Microbial Extracellular Vesicles

Yang J, Hong G, Kim YS, Seo H, Kim S, McDowell A, Lee WH, Kim YS, Oh YM, Cho YS, Choi YW, Kim YY, Jee YK, Kim YK

Purpose: Recently, there has been a rise in the interest to understand the composition of indoor dust due to its association with lung diseases such as asthma, chronic obstructive pulmonary...
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Severe Cutaneous Adverse Reactions to Antiepileptic Drugs: A Nationwide Registry-Based Study in Korea

Park CS, Kang DY, Kang MG, Kim S, Ye YM, Kim SH, Park HK, Park JW, Nam YH, Yang MS, Jee YK, Jung JW, Kim SH, Kim CW, Kim MY, Kim JH, Lee J, Lee JG, Kim SH, La HO, Kim MH, Park SJ, Koh YI, Lee SM, Kwon YE, Jin HJ, Kim HK, Kang HR, Choi JH, Korean Registry of Severe Cutaneous Adverse Reactions Consortium

PURPOSE: Severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) to antiepileptic drug (AED), are rare, but...
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How to Apply the Concept of Cough Hypersensitivity in Clinical Practice?

Yang MS, Jee YK

No abstract available.
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Phenotypes of Severe Cutaneous Adverse Reactions Caused by Nonsteroidal Anti-inflammatory Drugs

Lee SY, Nam YH, Koh YI, Kim SH, Kim S, Kang HR, Kim MH, Lee JG, Park JW, Park HK, La HO, Kim MY, Park SJ, Kwon YE, Jung JW, Kim SH, Kim CW, Yang MS, Kang MG, Lee JY, Kim JH, Kim SH, Hur GY, Jee YK, Jin HJ, Park CS, Jeong YY, Ye YM

PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are common cause of severe cutaneous adverse reactions (SCARs). The present study aimed to investigate the characteristics of SCARs induced by NSAIDs in the Korean...
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The Effects of Short-Term and Very Short-Term Particulate Matter Exposure on Asthma-Related Hospital Visits: National Health Insurance Data

Song DJ, Choi SH, Song WJ, Park KH, Jee YK, Cho SH, Lim DH

PURPOSE: The purpose of this study was to investigate the effects of short-term and very short-term exposure to particulate matter (PM) exceeding the daily average environmental standards for Korea (≤100...
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The Fas Signaling Pathway Is a Common Genetic Risk Factor for Severe Cutaneous Drug Adverse Reactions Across Diverse Drugs

Park HW, Kim SH, Chang YS, Kim SH, Jee YK, Lee AY, Jang IJ, Park HS, Min KU

PURPOSE: Human leukocyte antigen (HLA) has been recognized as the most important genetic risk factor for severe cutaneous adverse drug reactions (SCARs) caused by certain drugs. However, cumulated observations suggest...
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The virtual asthma guideline e-learning program: learning effectiveness and user satisfaction

Kang SY, Kim SH, Kwon YE, Kim TB, Park HK, Park HW, Chang YS, Jee YK, Moon HB, Min KU, Cho SH

BACKGROUND/AIMS: Effective educational tools are important for increasing adherence to asthma guidelines and clinical improvement of asthma patients. We developed a computer-based interactive education program for asthma guideline named the...
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Is Omalizumab a Problem-Solving Remedy in Severe Asthma?

Kim DH, Jee YK

No abstract available.
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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

Chelakkot , Choi Y, Kim DK, Park HT, Ghim J, Kwon Y, Jeon J, Kim MS, Jee YK, Gho YS, Park HS, Kim YK, Ryu SH

The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity...
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KAAACI Evidence-Based Clinical Practice Guidelines for Chronic Cough in Adults and Children in Korea

Song DJ, Song WJ, Kwon JW, Kim GW, Kim MA, Kim MY, Kim MH, Kim SH, Kim SH, Kim SH, Kim ST, Kim SH, Kim JK, Kim JH, Kim HJ, Kim HB, Park KH, Yoon JK, Lee BJ, Lee SE, Lee YM, Lee YJ, Lim KH, Jeon YH, Jo EJ, Jee YK, Jin HJ, Choi SH, Hur GY, Cho SH, Kim SH, Lim DH

Chronic cough is common in the community and causes significant morbidity. Several factors may underlie this problem, but comorbid conditions located at sensory nerve endings that regulate the cough reflex,...
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Multifaceted interventions to reduce acute exacerbations in elderly asthmatics

Lee SH, Song WJ, Park HW, Kang MG, Kim SH, Park HK, Kim SH, Kwon YE, Kim TB, Lee BJ, Jee YK, Choi BW, Cho SH, Kim SS

BACKGROUND: Although many risk factors are known to be associated with poor asthma outcomes in the elderly, the literature on the effect of risk factor control on asthma outcomes in...
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Real-Life Clinical Use of Symbicort® Maintenance and Reliever Therapy for Asthmatic Patients in Korea

Kim SH, Kim TB, Kim SH, Park HW, Song SH, Jeong JW, Jee YK, Park SW, Kim MS, Yoon HJ

The aim of this study was to examine the daily practice patterns of Symbicort® Maintenance and Reliever Therapy (SMART) in Korean asthmatic patients and to analyze clinical signs related to...
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Serum micronutrients levels and clinical features of elderly asthmatics

Lee SH, Song WJ, Park HW, Kim SH, Park HK, Kim SH, Kwon YE, Kim TB, Lee BJ, Jee YK, Choi BW, Cho SH, Kim SS

PURPOSE: The prevalence of asthma in the elderly is rapidly increasing. However, we do not fully understand the pathogenesis of elderly asthma, especially for the roles of micronutrients. This study...
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Patterns of Inhalant Allergen Sensitization and Geographical Variation in Korean Adults: A Multicenter Retrospective Study

Kang MG, Kim MY, Song WJ, Kim S, Jo EJ, Lee SE, Kwon JW, Lee SM, Park CS, Park HK, Park HW, Chang YS, Lee J, Lee YM, Jee YK, Lee JM, Choi IS, Cho SH

PURPOSE: Inhalant allergen sensitization is one of the major factors involved in the pathogenesis of allergic respiratory diseases. However, the sensitization is determined by interactions between genetic and environmental factors....
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Genetic polymorphisms of interleukin-10 and transforming growth factor-β1 and antituberculosis drugs-induced liver injury

Jung S, Kim SH, Sohn JW, Yoon HJ, Shin DH, Jee YK, Kim SH

PURPOSE: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of medications. Previously, IL-10 gene polymorphism has been reported to be associated with...
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Importance of indoor dust biological ultrafine particles in the pathogenesis of chronic inflammatory lung diseases

Yang J, Kim YK, Kang TS, Jee YK, Kim YY

The role of infectious agents in the etiology of inflammatory diseases once believed to be non-infectious is increasingly being recognized. Many bacterial components in the indoor dust can evoke inflammatory...
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Methazolamide-induced toxic epidermal necrolysis confirmed by lymphocyte activation test

Han KH, Hong KH, Kim DH, Kim YS, Park JS, Kim SH, Jee YK

Among various dermatological entities, toxic epidermal necrolysis (TEN) is a rare but potentially fatal delayed hypersensitivity reaction to numerous medications. A 38-year-old male presented with systemic hypersensitivity reaction, such as...
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House Dust Mite-Derived Chitin Enhances Th2 Cell Response to Inhaled Allergens, Mainly via a TNF-α-Dependent Pathway

Choi JP, Lee SM, Choi HI, Kim MH, Jeon SG, Jang MH, Jee YK, Yang S, Cho YJ, Kim YK

PURPOSE: Chitin is a potent adjuvant in the development of immune response to inhaled allergens in the airways. According to other studies, chitin is known as multi-faced adjuvants which can...
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IgG Sensitization to Extracellular Vesicles in Indoor Dust Is Closely Associated With the Prevalence of Non-Eosinophilic Asthma, COPD, and Lung Cancer

Kim YS, Choi JP, Kim MH, Park HK, Yang S, Kim YS, Kim TB, Cho YS, Oh YM, Jee YK, Lee SD, Kim YK

PURPOSE: Recent experimental evidence shows that extracellular vesicles (EVs) in indoor dust induce neurtrophilic pulmonary inflammation, which is a characteristic pathology in patients with severe asthma and chronic obstructive pulmonary...
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16S rRNA gene-based metagenomic analysis reveals differences in bacteria-derived extracellular vesicles in the urine of pregnant and non-pregnant women

Yoo JY, Rho M, You YA, Kwon EJ, Kim MH, Kym S, Jee YK, Kim YK, Kim YJ

Recent evidence has indicated that bacteria-derived extracellular vesicles (EVs) are important for host–microbe communication. The aims of the present study were to evaluate whether bacteria-derived EVs are excreted via the...
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