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IDH2 gene deficiency accelerates unilateral ureteral obstructioninduced kidney inflammation through oxidative stress and activation of macrophages

Kim JI, Noh MR, Yoon GE, Jang HS, Kong MJ, Park KM

Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) produces NADPH, which is known to inhibit mitochondrial oxidative stress. Ureteral obstruction induces kidney inflammation and fibrosis via oxidative stress. Here, we investigated the...
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Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging

Kim YJ, Lee JE, Jang HS, Hong SY, Lee JB, Park SY, Hwang JS

The role of particulate matter (PM) in health problems including cardiovascular diseases (CVD) and pneumonia is becoming increasingly clear. Polycyclic aromatic hydrocarbons, major components of PM, bind to aryl hydrocarbon...
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Prediction of Tumor Temperature in Regional Hyperthermia by Using LED Luminance

Lee J, Hwang J, Seol Y, Oh T, An Ny, Han K, Jang HS, Choi BO, Kang Yn

  • KMID: 2510114
  • Prog Med Phys.
  • 2020 Sep;31(S1):S67.
Introduction: Hyperthermia is used to destroy tumors by generating heat in the body (40-45°C). In particular, regional hyperthermia entails intense heating of tumors rather than raising the temperature of the...
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Epidemiologic Features of Distal Radius Fractures in Severe Trauma Patients at the Busan Regional Trauma Center

Kim DH, Kwak SH, Jang HS, An SJ, Lee GE, Cho YJ, Lee SH

Purpose: Distal radius fractures (DRFs) are often observed in simple trauma in older women with osteoporosis, and severe trauma caused by traffic or fall accidents. In this study, we aim...
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Characterization of Amylolytic Activity by a Marine-Derived Yeast Sporidiobolus pararoseus PH-Gra1

Kwon YM, Choi HS, Lim JY, Jang HS, Chung D

Marine yeasts have tremendous potential in industrial applications but have received less attention than terrestrial yeasts and marine filamentous fungi. In this study, we have screened marine yeasts for amylolytic...
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Extraneural CGRP Upregulates TGF-β1 through RAMP1 Signaling during Mechanical Stretch in Kidney Proximal Tubule Epithelial Cells

Moon D, Padanilam BJ, Jang HS, Kim J

Calcitonin gene-related peptide (CGRP) derived from sensory neurons contributes to the development of renal tubulointerstitial fibrosis during ureteral obstruction through upregulation of profibrotic factors. However, the mechanism by which CGRP...
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Combined Delivery of Two Different Bioactive Factors Incorporated in Hydroxyapatite Microcarrier for Bone Regeneration

Kim TW, Ahn WB, Kim JM, Kim JH, Kim TH, Perez RA, Jang HS

BACKGROUND: The delivery of growth factors using a carrier system presents a promising and innovative tool in tissue engineering and dentistry today. Two of the foremost bioactive factors, bone morphogenetic...
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Longitudinal associations between occupational stress and depressive symptoms

Kim HD, Park SG, Won Y, Ju H, Jang SW, Choi G, Jang HS, Kim HC, Leem JH

Background: Most of the studies that have examined the association between the sub-factors of occupational stress and depressive symptoms have used cross-sectional data. However, our study has longitudinally measured the...
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The relationship between precarious employment and subjective well-being in Korean wage workers through the Cantril ladder Scale

Choi G, Park SG, Won Y, Ju H, Jang SW, Kim HD, Jang HS, Kim HC, Leem JH

Background: The global labor market is moving towards increasing job instability. Relatively few studies have examined the relationship between precarious employment and subjective well-being using quantitative scales. We evaluated the...
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Simultaneous Analysis of Four Standards of The Herbal Formula, DF-02, of Ephedra intermedia and Rheum palmatum, using by High Performance Liquid Chromatography-Ultraviolet Detector (HPLC-UVD)

Choi SY, Jeong B, Jang HS, Lee J, Kwon YS, Yoon Y, Shin SS, Yang H

The herbal formula, DF-02, consisting of Ephedra intermedia and Rheum palmatum are used for the treatment of the metabolic diseases such as obesity and liver fibrosis in Korean local clinics....
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Renal sympathetic nerve activation via α₂-adrenergic receptors in chronic kidney disease progression

Jang HS, Kim J, Padanilam

Chronic kidney disease (CKD) is increasing worldwide without an effective therapeutic strategy. Sympathetic nerve activation is implicated in CKD progression, as well as cardiovascular dysfunction. Renal denervation is beneficial for...
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Retrospective analysis of intensity-modulated radiotherapy and three-dimensional conformal radiotherapy of postoperative treatment for biliary tract cancer

Lee HC, Lee JH, Lee SW, Lee JH, Yu M, Jang HS, Kim SH

PURPOSE: This study was conducted to compare the outcome of three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for the postoperative treatment of biliary tract cancer. MATERIALS AND METHODS: From February...
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Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells

Moon D, Yoon SP, Jang HS, Noh MR, Ha L, Padanilam , Kim J

Calcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in primary afferent sensory neurons. Exogenous CGRP can induce cell death in kidney tubular cells. The objective of this study was...
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Particulate Matter-Induced Aryl Hydrocarbon Receptor Regulates Autophagy in Keratinocytes

Jang HS, Lee JE, Myung CH, Park JI, Jo CS, Hwang JS

Particulate matter (PM), which refers to the mixture of particles present in the air, can have harmful effects. Damage to cells by PM, including disruption of organelles and proteins, can...
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Major Limb Replantation of Lower Leg Amputation with Ipsilateral Distal Femoral Comminuted Fracture in Old Age: A Case Report

Ahn TY, Rhee SJ, Kwak SH, Jang HS, Lee SH

The development of microsurgical techniques has also increased the success rate of replantation surgery. This paper reports the results of limb replantation performed on a lower extremity amputation that was...
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Treatment Outcome after Fractionated Conformal Radiotherapy for Hepatocellular Carcinoma in Patients with Child-Pugh Classification B in Korea (KROG 16-05)

Bae SH, Park HC, Yoon WS, Yoon SM, Jung IH, Lee IJ, Kim JW, Seong J, Kim TH, Nam TK, Choi Y, Lee SY, Jang HS, Lee DS, Kim JH

PURPOSE: There is limited data on radiotherapy (RT) for hepatocellular carcinoma (HCC) in patients with Child-Pugh classification B (CP-B). This study aimed to evaluate the treatment outcomes of fractionated conformal...
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Relationship between occupational sunlight exposure and the incidence of renal cancer

Jang HS, Leem JH, Jeon SS, Park SG, Lee S, Kang Y, Choi G, Kim HD, Ju H, Jang SW, Won Y, Kim HC

BACKGROUND: The risk factors for renal cancer include smoking, obesity, hypertension, and exposure to trichloroethylene. Recent studies have shown that low sunlight exposure increases the risk of developing a range...
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The Impact of Surgical Timing on Pathologic Tumor Response after Short Course and Long Course Preoperative Chemoradiation for Locally Advanced Rectal Adenocarcinoma

Lee SW, Lee JH, Lee IK, Oh ST, Kim DY, Kim TH, Oh JH, Baek JY, Chang HJ, Park HC, Kim HC, Chie EK, Nam TK, Jang HS

PURPOSE: A pooled analysis of multi-institutional trials was performed to analyze the effect of surgical timing on tumor response by comparing short course concurrent chemoradiotherapy (CCRT) with long course CCRT...
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Interobserver variation in target volume for salvage radiotherapy in recurrent prostate cancer patients after radical prostatectomy using CT versus combined CT and MRI: a multicenter study (KROG 13-11)

Lee E, Park W, Ahn SH, Cho JH, Kim JH, Cho KH, Choi YM, Kim JS, Kim JH, Jang HS, Kim YS, Nam TK

PURPOSE: To investigate interobserver variation in target volume delineations for prostate cancer salvage radiotherapy using planning computed tomography (CT) versus combined planning CT and magnetic resonance imaging (MRI). MATERIALS AND METHODS:...
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Fasciocutaneous Propeller Flap Based on Perforating Branch of Ulnar Artery for Soft Tissue Reconstruction of the Hand and Wrist

Jang HS, Lee YH, Kim MB, Chung JY, Seok HS, Baek GH

BACKGROUND: A skin defect of the hand and wrist is a common manifestation in industrial crushing injuries, traffic accidents or after excision of tumors. We reconstructed a skin defect in...
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