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Isolation and molecular characterizations of canine distemper virus from a naturally infected Korean dog using Vero cells expressing dog signaling lymphocyte activation molecule

Yang DK, Kim HH, Lee S, Yoon YS, Park J, Oh D, Yoo JY, Ji M, Han B, Oh S, Hyun BH

Background: Canine distemper virus (CDV) infection results in high morbidity and mortality in dogs. There has been no report about Isolation of Korean CDV since 1980 in Korea. Objectives: To investigate...
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Genotype-specific neutralizing antibody titers against Japanese encephalitis virus genotypes 1 and 3 in horses immunized with a genotype 3 vaccine

Kim HH, Yang DK, Ji M, Lee SK, Hyun BH

Purpose: Japanese encephalitis is one of the most important mosquito-borne and zoonotic diseases in Asia and the Pacific region. Although the dominant Japanese encephalitis virus (JEV) genotype has shifted from...
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Development of indirect ELISA for the detection of canine adenovirus type 2 antibodies in dog sera

Yang DK, Kim HH, Lee S, Oh D, Yoo JY, Hyun BH

Background: Canine adenovirus type 2 (CAV-2) induces infectious laryngotracheitis in members of the family Canidae, including dogs. To date, no ELISA kits specific for CAV-2 antibody have been commercialized for...
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Evaluation of Commercial Immunochromatographic Test Kits for the Detection of Canine Distemper Virus

Yang DK, Kim HH, Lee J, Ji M, Oh S, Lee HS, Hyun BH

The rapid diagnosis of canine distemper virus (CDV) helps to determine the treatment of dogs in veterinary clinics. We evaluated the performance of seven commercial rapid immunochromatographic test (RICT) kits...
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Cytotoxicity of natural killer cells on canine mammary carcinoma cells

Jeong DU, Byeon JS, Gu NY, Jung M, Kim EH, Kim HS, Cho IS, Song JY, Hyun BH, Lee J

Natural killer (NK) cells play have a crucial role in the early phase of immune responses against various pathogens. We compared characteristics of canine NK cells against two canine mammary...
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Development of an Indirect ELISA Featuring Plates Coated with Column Chromatographically Purified Canine Adenovirus Type-1 Antigen

Yang DK, Kim HH, Lee S, Ji M, Han BH, Oh S, Hyun BH

Canine adenovirus type 1 (CAV-1) causes infectious hepatitis in members of the family Canidae, including dogs. An indirect enzyme-linked immunosorbent assay (I-ELISA) that detects CAV-1 antibodies is required for large-throughput...
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Isolation and Molecular Characterization of Feline Herpesvirus 1 from Naturally Infected Korean Cats

Yang DK, Kim HH, Park YR, Yoo JY, Choi SS, Park Y, An S, Park J, Kim J, Kim HJ, Lee J, Hyun BH

Feline herpesvirus type 1 (FHV-1) causes respiratory and ocular disease in cats. Although isolates of FHV-1 circulating in cats have been reported worldwide, Korean FHV-1 isolates and their features have not...
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Biological and molecular characterization of feline caliciviruses isolated from cats in South Korea

Yang DK, Park YR, Yoo JY, Choi SS, Park Y, An S, Park J, Kim HJ, Kim J, Kim HH, Hyun BH

Feline calicivirus (FCV) infection results in a common upper respiratory disease associated with oral ulceration in cats. Although FCV infection has been reported in cats worldwide, the biologic and genetic features...
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Immunogenicity of a new, inactivated canine adenovirus type 2 vaccine for dogs

Yang DK, Kim HH, Yoo JY, Ji M, Han BH, Oh S, Hyun BH

PURPOSE: We constructed a new canine adenovirus type 2 (CAV-2) vaccine candidate using the recently isolated Korean CAV-2 strain; we termed the vaccine APQA1701-40P and evaluated its safety and immunogenicity...
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Antibody responses after vaccination against equine influenza in Korea in 2016–2018

Equine influenza (EI) is the main cause of respiratory illness in equines across the globe and is caused by equine influenza A virus (EIV-A), which has impacted the equine industry...
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The effect of near-infrared fluorescence conjugation on the anti-cancer potential of cetuximab

Yun JY, Hyun BH, Nam SY, Yun YW, Lee HJ, Lee BJ

This study investigated the anti-cancer potential of a near-infrared fluorescence (NIRF) molecule conjugated with Cetuximab (Cetuximab-NIRF) in six-week-old female BALB/c athymic (nu+/nu+) nude mice. A431 cells were cultured and injected...
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Antigenic characterization of classical swine fever virus YC11WB isolates from wild boar

Lim SI, Kim YK, Lim JA, Han SH, Hyun HS, Kim KS, Hyun BH, Kim JJ, Cho IS, Song JY, Choi SH, Kim SH, An DJ

Classical swine fever (CSF), a highly contagious disease that affects domestic pigs and wild boar, has serious economic implications. The present study examined the virulence and transmission of CSF virus...
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An oral Aujeszky's disease vaccine (YS-400) induces neutralizing antibody in pigs

Yang DK, Kim HH, Choi SS, Hyun BH, Song JY

PURPOSE: Aujeszky's disease (AD) is an economically important disease affecting both wild and domestic pigs of the species Sus scrofa. A previous study yielded serological evidence of AD in Korean...
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Cross-Reactivity of Porcine Immunoglobulin A Antibodies with Fecal Immunoglobulins of Wild Boar (Sus scrofa) and Other Animal Species

Seo SW, Yoo SJ, Sunwoo S, Hyun BH, Lyoo YS

Fecal samples obtained from wild boar habitats are useful for the surveillance of diseases in wild boar populations; however, it is difficult to determine the species of origin of feces...
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A single immunization with recombinant rabies virus (ERAG3G) confers complete protection against rabies in mice

Yang DK, Nakagawa K, Ito N, Kim HH, Hyun BH, Nah JJ, Sugiyama M, Song JY

PURPOSE: New alternative bait rabies vaccines applicable to pet dogs and wild animals are needed to eradicate rabies in Korea. In this study, recombinant rabies virus, ERAG3G strain was constructed...
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Development of osteoporosis animal model using micropigs

Kim SW, Kim KS, Solis CD, Lee MS, Hyun BH

  • KMID: 2312111
  • Lab Anim Res.
  • 2013 Sep;29(3):174-177.
Osteoporosis is a known major health problem and a serious disease of the bone, there has been a great need to develop more and newer animal models for this disease....
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Isolation and characterization of orf viruses from Korean black goats

Oem JK, Chung JY, Kim YJ, Lee KK, Kim SH, Jung BY, Hyun BH

Five cases of orf virus infection in Korean black goats were diagnosed in our laboratory between 2010 and 2011. One orf virus (ORF/2011) was isolated from an ovine testis cell...
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A survey of porcine reproductive and respiratory syndrome among wild boar populations in Korea

Choi EJ, Lee CH, Hyun BH, Kim JJ, Lim SI, Song JY, Shin YK

  • KMID: 2391996
  • J Vet Sci.
  • 2012 Dec;13(4):377-383.
No information is currently available on porcine reproductive and respiratory syndrome virus (PRRSV) infection in wild boars (Sus scrofa) in Korea. In this study, the status of PRRS in wild...
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Detection of Neutralizing Antibody Against Japanese Encephalitis Virus in Wild Boars of Korea

Yang DK, Kim HH, Hyun BH, Lim SI, Nam YK, Nah JJ, Song JY

Several species of animals, including horses and pigs, can be infected with Japanese encephalitis virus (JEV). Wild boars (Sus scrofa) are also considered to be an effective amplifying host for...
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Analysis of in vitro apoptosis induced by virulent Korean isolate of classical swine fever virus in peripheral blood B cell line

Kim SM, Lim SI, Song JY, Hyun BH

  • KMID: 1431986
  • Korean J Vet Res.
  • 2012 Dec;52(4):259-262.
Classical swine fever (CSF) is a highly contagious disease among swine that has an important economic impact on worldwide. One clinical symptom of CSF is leukopenia, in particular lymphopenia, which...
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