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Combination Therapy With Polydeoxyribonucleotide and Pirfenidone Alleviates Symptoms of Acute Respiratory Distress Syndrome in Human Lung Epithelial A549 Cells

Hwang JJ, Ko IG, Jin JJ, Hwang L, Kim SH, Jeon JW, Paik SS, Chang BS, Choi CW

Purpose: Acute respiratory distress syndrome (ARDS) is characterized by its acute onset of symptoms such as bilateral pulmonary infiltrates, severe hypoxemia, and pulmonary edema. Many patients with ARDS survive in...
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Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway

Kim SE, Ko IG, Ji ES, Jin JJ, Hwang L, Kim SH, Cho S, Kim CJ, Kim K, Kim KH

PURPOSE: Circadian rhythm affects learning process, memory consolidation, and long-term memory. In this study, the alleviating effect of exercise on circadian rhythm disruption-induced memory deficits was investigated. METHODS: BMAL1 knockdown transgenic...
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Effect of Polydeoxyribonucleotide on Lipopolysaccharide and Sevoflurane-Induced Postoperative Cognitive dysfunction in Human Neuronal SH-SY5Y Cells

Jeong H, Chung JY, Ko IG, Kim SH, Jin JJ, Hwang L, Moon EJ, Lee BJ, Yi JW

PURPOSE: Postoperative cognitive dysfunction (POCD) is a complication of surgery characterized by acute cognitive dysfunction, memory impairment, and loss of attention. The effect of polydeoxyribonucleotide (PDRN) on the POCD environment...
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Add-on Therapy With the α-Blockers Tamsulosin and Naftopidil Improves Voiding Function by Enhancing Neuronal Activity in Prostatic Hyperplasia Rats

Ko IG, Hwang L, Jin JJ, Kim SH, Han JH, Jeon JW, Cho ST

PURPOSE: Benign prostatic hyperplasia (BPH) impacts quality of life in men by causing lower urinary tract symptoms. α1-Adrenoceptor (α1-AR) blockers improve lower urinary tract symptoms. We investigated the efficacy of...
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Dexmedetomidine Ameliorates Sleep Deprivation-Induced Depressive Behaviors in Mice

Moon EJ, Ko IG, Kim SE, Jin JJ, Hwang L, Kim CJ, An H, Lee BJ, Yi JW

PURPOSE: Sleep deprivation induces depressive symptoms. Dexmedetomidine is a α2-adrenoreceptor agonist and this drug possesses sedative, anxiolytic, analgesic, and anesthetic-sparing effect. In this study, the action of dexmedetomidine on sleep...
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Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats

Park JH, Ko IG, Kim SE, Jin JJ, Hwang L, Kim CJ, Yoon SH, Hong J, Chung JY, Lee DW

PURPOSE: Dexmedetomidine, an α2-adrenergic agonist, provides sedative and analgesic effects without significant respiratory depression. Dexmedetomidine has been suggested to have an antiapoptotic effect in response to various brain insults. We...
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Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats

Ko IG, Moon BM, Kim SE, Jin JJ, Hwang L, Ji ES, Kim CJ, Kim TH, Choi HH, Chung KJ

PURPOSE: Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The...
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Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome

Pokkunuri , Pimentel M, Morales W, Jee SR, Alpern J, Weitsman S, Marsh Z, Low K, Hwang L, Khoshini R, Barlow GM, Wang H, Chang C

  • KMID: 2325954
  • J Neurogastroenterol Motil.
  • 2012 Oct;18(4):434-442.
BACKGROUND/AIMS: Campylobacter jejuni infection is a leading cause of acute gastroenteritis, which is a trigger for post-infectious irritable bowel syndrome (PI-IBS). Cytolethal distending toxin (CDT) is expressed by enteric pathogens...
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Clinical Features and Prognosis of Patients Who Started Hemodialysis Treatment over 60 Years Old

Kim SH, Jeon YD, Kwon NH, Hwang LS, Kang HS, Nam KS

  • KMID: 1481840
  • J Korean Geriatr Soc.
  • 2008 Jun;12(2):95-101.
BACKGROUND: Observation on the hemodialysis treatment; whether there are any different effects on mortality rate, side effects, or effectiveness of the treatment depending on patients' age. METHODS: Chronic renal failure patients...
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Compliance with Atovaquone-Proguanil against Malaria of Korean Travelers Abroad

Kwon NH, Park TS, Kang HS, Kim SH, Hwang LS, Noh HJ, Bang JH, Kim JY, Shin HS

BACKGROUND: Recently, many Korean people travel abroad where malaria is prevalent. However, in Korea, relatively little is known about compliance of chemoprophylaxis against malaria. This study was performed to determine...
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Prevalence of Infectious Diseases in the Homeless Admitted to a Tertiary Care Center

Ham SW, Nam KS, Noh HJ, Hong KD, Hwang LS, Bang JH, Shin HS

  • KMID: 1528881
  • Infect Chemother.
  • 2007 Aug;39(4):183-188.
BACKGROUND: Despite the expected high prevalence of several infectious diseases among the homeless, a majority of them have not received screening test and early treatment. MATERIALS AND METHODS: The subjects...
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A Case of Pancreaticobiliary Duct Obstruction due to Pancreatic Tuberculosis Combined with a Colon Adenocarcinoma and Tuberculous Colitis

Hwang LS, Nam SW, Lee SE, Kwon NH, Kang HS, Kim SH, Nam KS, Hong KD, Ham SW, Jeon YW, Park SH, Jin SC, Ahn HS

  • KMID: 1962140
  • Korean J Gastrointest Endosc.
  • 2007 Oct;35(4):267-271.
Systemic manifestation of tuberculosis is common, but tuberculous biliary obstruction of the pancreas and a colon adenocarcinoma with combined colonic tuberculosis is an uncommon disorder. We encountered a case of...
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Role of Thigh Muscle in the Carotid artery Intima-Media Thickness and Insulin resistance

Hwang LJ, Park KS, Chae YT, Shi KD, Kim SK, Park SW, Kim YL, Cho YW, Choi YK, Lee SJ

BACKGROUND: There have been recent reports that the fat distribution within skeletal muscle and the amount of muscle mass are associated with insulin resistance and the development of type 2...
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Factors Influencing Osteoporosis

Lee JK, Kim EJ, Suk MH, Kim EY, Hwang LI

  • KMID: 2330298
  • J Korean Community Nurs.
  • 2003 Jun;14(2):253-262.
PURPOSE: This study was carried out to identify factors influencing osteoporosis in women at pre- and post-menopausal state. METHODS: The subjects of this study were 52 pre-menopausal and 125 post-menopausal women...
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Utilization of Alternative Therapies in Cancer Patients

Lee KS, Ahn HS, Hwang LI, Lee YS, Koo BH

  • KMID: 2329110
  • J Korean Cancer Assoc.
  • 1998 Apr;30(2):203-213.
PURPOSE: To determine patient's use of alternative cancer therapies, as well as the characteristics of the patients who used these therapies, descriptive study was conducted at the one college hospital...
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