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Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging

Kang MS, Kim TH, Choi JH, Kim W, Jung HY, Hwang IK, Kim W, Kwon HJ, Kim DW

Fat-mass and obesity-associated protein (Fto) is highly expressed in the brain including, the hippocampus, and its expression is significantly decreased in the brain of Alzheimer’s disease patients. In the present...
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Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus

Kwon HJ, Kim W, Jung HY, Kang MS, Kim JW, Hahn KR, Yoo DY, Yoon YS, Hwang IK, Kim DW

In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration into...
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Impact of Pulmonary Tuberculosis on the EGFR Mutational Status and Clinical Outcome in Patients with Lung Adenocarcinoma

Hwang IK, Paik SS, Lee SH

PURPOSE: Although it has been suggested that pulmonary tuberculosis (TB) is associated with increased risk of lung cancer, the exact mechanism is not clearly identified. We investigated the effect of...
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Decrease in glucose transporter 1 levels and translocation of glucose transporter 3 in the dentate gyrus of C57BL/6 mice and gerbils with aging

Lee KY, Yoo DY, Jung HY, Baek L, Lee H, Kwon HJ, Chung JY, Kang SH, Kim DW, Hwang IK, Choi JH

In the present study, we compared the cell-specific expression and changes protein levels in the glucose transporters (GLUTs) 1 and 3, the major GLUTs in the mouse and gerbil brains...
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Pemetrexed Continuation Maintenance versus Conventional Platinum-Based Doublet Chemotherapy in EGFR-Negative Lung Adenocarcinoma: Retrospective Analysis

Paik SS, Hwang IK, Park MJ, Lee SH

BACKGROUND: Although targeted therapy and immuno-oncology have shifted the treatment paradigm for lung cancer, platinum-based combination is still the standard of care for advanced non-small cell lung cancer (NSCLC). Pemetrexed...
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Ultrasonographic Interval Changes in Solid Thyroid Nodules after Ultrasonography-Guided Fine-Needle Aspiration

Hwang IJ, Kim DW, Lee YJ, Choo HJ, Jung SJ, Baek HJ

OBJECTIVE: None of the previous studies have investigated the interval change in ultrasonography (US) features of solid thyroid nodules (STNs) after US-guided fine-needle aspiration (US-FNA). This study aimed to assess...
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Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus

Kwon HJ, Jung HY, Hahn KR, Kim W, Kim JW, Yoo DY, Yoon YS, Hwang IK, Kim DW

Bacopa monnieri is a medicinal plant with a long history of use in Ayurveda, especially in the treatment of poor memory and cognitive deficits. In the present study, we hypothesized...
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Changes of myelin basic protein in the hippocampus of an animal model of type 2 diabetes

Nam SM, Kwon HJ, Kim W, Kim JW, Hahn KR, Jung HY, Kim DW, Yoo DY, Seong JK, Hwang IK, Yoon YS

In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in...
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Improved Transfection Efficiency and Metabolic Activity in Human Embryonic Stem Cell Using Non-Enzymatic Method

Kim CY, Hwang IK, Kang C, Chung EB, Jung CR, Oh H, Jeong YH, Moon SH, Kim JS, Hong KS, Park JH, Chung HM

Human embryonic stem cells (hESCs) are pluripotent cells widely used in conventional and regenerative medicine due to their ability to self-renew, proliferate and differentiate. Recently, genetic modification of stem cells...
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Unexpected Death by Sepsis of Staphylococcus aureus with Infective Endocarditis and Paravertebral Abscess in a Fisherman during Sailing out for Fish: An Autopsy Case

Kim YS, Hwang IK, Moon S, Park JH, Lee YS

Staphylococcus aureus is an important cause of human infections, and it is also a commensal that colonizes the nose, axillae, vagina, throat, or skin surfaces. S. aureus has increasingly been...
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Outcomes of Treatment for Malignant Peripheral Nerve Sheath Tumors: Different Clinical Features Associated with Neurofibromatosis Type 1

Hwang IK, Hahn SM, Kim HS, Kim SK, Kim HS, Shin KH, Suh CO, Lyu CJ, Han JW

PURPOSE: Malignant peripheral nerve sheath tumors (MPNSTs) are a rare subtype of sarcoma that occur spontaneously or in association with neurofibromatosis type 1 (NF-1). This study aimed to clinically differentiate...
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Age-related change of Iba-1 immunoreactivity in the adult and aged gerbil spinal cord

Lee KY, Kang JY, Yun JI, Chung JY, Hwang IK, Won MH, Choi JH

In the present study, we examined change of ionized calcium-binding adapter molecule 1 (Iba-1) in the adult and aged gerbil spinal cords. Significant change of morphological feature and neuronal cell...
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Neuronal maturation in the hippocampal dentate gyrus via chronic oral administration of Artemisa annua extract is independent of cyclooxygenase 2 signaling pathway in diet-induced obesity mouse model

Baek HK, Kim PS, Song JA, Choi DH, Kim DE, Oh SI, Park SK, Kim SJ, Song KD, Hwang IK, Seo HS, Yi SS

Recently, we reported that Artemisia annua (AA) has anti-adipogenic properties in vitro and in vivo. Reduction of adipogenesis by AA treatment may dampen systemic inflammation and protect neurons from cytokine-induced...
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Immunohistochemical localization of glucose transporter 1 and 3 in the scrotal and abdominal testes of a dog

Hahn KR, Jung HY, Yoo DY, Kim JW, Kim YH, Jo YK, Kim GA, Chung JY, Choi JH, Hwang IK, Jang G, Yoon YS

Glucose is essential for testicular function; the uptake of carbohydrate-derived glucose by cells is mediated by glucose transporters (GLUTs). In the present study, we investigated the activity of GLUT1 and...
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Dendropanax morbifera Léveille extract ameliorates D-galactose-induced memory deficits by decreasing inflammatory responses in the hippocampus

Lee KY, Jung HY, Yoo DY, Kim W, Kim JW, Kwon HJ, Kim DW, Yoon YS, Hwang IK, Choi JH

In the present study, we examined the effects of Dendropanax morbifera Léveille leaf extract (DML) on D-galactose-induced morphological changes in microglia and cytokines, including pro-inflammatory cytokines (interleukin [IL]-1β, IL-6, and...
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Presence of bilirubin in bronchobiliary fistula easily confirmed with urinary dipstick test and treated with embolization

Kim MJ, Kim SH, Hwang IK, Kim HO, Jang NE, Paik SS, Park MJ

No abstract available.
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Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress

Nam SM, Kim JW, Yoo DY, Kim W, Jung HY, Choi JH, Hwang IK, Seong JK, Yoon YS

Aluminum (Al) accumulation increases with aging, and long-term exposure to Al is regarded as a risk factor for Alzheimer's disease. In this study, we investigated the effects of Al and/or...
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Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog

Jung HY, Yoo DY, Jo YK, Kim GA, Chung JY, Choi JH, Jang G, Hwang IK

Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology...
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Reduction of adult hippocampal neurogenesis is amplified by aluminum exposure in a model of type 2 diabetes

Nam SM, Kim JW, Yoo DY, Jung HY, Choi JH, Hwang IK, Seong JK, Yoon YS

In this study, we investigated the effects of chronic aluminum (Al) exposure for 10 weeks on cell proliferation and neuroblast differentiation in the hippocampus of type 2 diabetic rats. Six-week-old...
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Postnatal changes in glucose transporter 3 expression in the dentate gyrus of the C57BL/6 mouse model

Jung HY, Yim HS, Yoo DY, Kim JW, Chung JY, Seong JK, Yoon YS, Kim DW, Hwang IK

In this study, we observed the ontogenetic changes in glucose transporter 3 (GLUT3) immunoreactivity, a major neuronal GLUT, in the dentate gyrus of mouse brains at various ages: postnatal day...
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