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Effects of Recombinant Human Growth Hormone on the Onset of Puberty, Leydig Cell Differentiation, Spermatogenesis and Hypothalamic KISS1 Expression in Immature Male Rats

Huh K, Nah WH, Xu Y, Park MJ, Gye MC

Purpose: Recombinant human growth hormone (rhGH) has been used to treat short stature and rhGH-related syndromes. However, there are concerns that rhGH-treatment may cause precocious puberty. We investigated the effects...
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Revised Korean Society of Infectious Diseases/National Evidence-based Healthcarea Collaborating Agency Guidelines on the Treatment of Patients with COVID-19

Kim SB, Ryoo S, Huh K, Joo EJ, Kim YJ, Choi WS, Kim YJ, Yoon YK, Heo JY, Seo YB, Jeong SJ, Park Da, Yu SY, Lee HJ, Kim J, Jin Y, Park J, Peck KR, Choi M, Yeom JS, KSoID(

Despite the global effort to mitigate the spread, coronavirus disease 2019 (COVID-19) has become a pandemic that took more than 2 million lives. There are numerous ongoing clinical studies aiming...
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Estimating Baseline Incidence of Conditions Potentially Associated with Vaccine Adverse Events: a Call for Surveillance System Using the Korean National Health Insurance Claims Data

Huh K, Kim YE, Radnaabaatar M, Lee DH, Kim DW, Shin SA, Jung J

Background: Vaccines against coronavirus disease 2019 (COVID-19) are raising concerns about vaccine safety, particularly in the context of large-scale immunization. To address public concerns, we measured the baseline incidence rates...
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Systemic Immunomodulatory Effects of Combinatorial Treatment of Thalidomide and Dexamethasone on T Cells and Other Immune Cells

Kim EJ, Kim JY, Choi HY, Lee H, Lee J, Kim MS, Kim YS, Huh KH, Kim BS

Purpose In organ transplantation, the need for immune modulation rather than immune suppression has been emphasized. In this study, we investigated whether combinatorial treatments of with thalidomide (TM) and dexamethasone (DX)...
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Acquired facial lipoatrophy: A report of 3 cases with imaging features

Lee C, Lee C, Kim JE, Kim JE, Yi WJ, Yi WJ, Heo MS, Heo MS, Lee SS, Lee SS, Han SS, Han SS, Choi SC, Choi SC, Huh KH, Huh KH

Acquired facial lipoatrophy is a rare disease with an unclear etiology and pathological pathway. The distinct causative factors of this disease have been not elucidated, but it is suspected to...
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Severe Thrombocytopenia in a Patient with COVID-19

Nham E, Ko JH, Jeong BH, Huh K, Cho SY, Kang CI, Chung DR, Peck KR

Coronavirus disease 2019 (COVID-19) outbreak is spreading rapidly all over the world, being a major threat to public health. Since clinical feature of COVID-19 has not been fully evaluated yet,...
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Long-term compensation of renal function after donor nephrectomy

Lee YP, Kim SJ, Lee J, Lee JG, Huh KH, Joo DJ, Kim SI, Kim YS, Kim MS

Background: Living donors are the major source of kidneys in countries with a shortage of deceased donors. Kidney donation after careful donor selection is generally accepted as a safe procedure,...
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Effect of Underlying Comorbidities on the Infection and Severity of COVID-19 in Korea: a Nationwide Case-Control Study

Ji W, Huh K, Kang M, Hong J, Bae GH, Lee R, Na Y, Choi H, Gong SY, Choi YH, Ko KP, Im JS, Jung J

Background: The coronavirus disease 2019 (COVID-19) pandemic is an emerging threat worldwide. It remains unclear how comorbidities affect the risk of infection and severity of COVID-19. Methods: This is a nationwide...
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Interim Guidelines on Antiviral Therapy for COVID-19

Kim SB, Huh K, Heo JY, Joo EJ, Kim YJ, Choi WS, Kim YJ, Seo YB, Yoon YK, Ku NS, Jeong SJ, Kim SH, Peck KR, Yeom JS

Since the first case was reported in Wuhan, Hubei Province, China on December 12, 2019, Coronavirus disease 2019 (COVID-19) has spread widely to other countries since January 2020. As of...
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Comparison of traumatic brain injury patients with brain computed tomography in the emergency department by age group

Huh KR, Kim JY, Choi SH, Yoon YH, Park SJ, Lee ES

Objective Traumatic brain injury (TBI) is an important public health concern due to its high prevalence and mortality rate among young people. We investigated the clinical and social characteristics of...
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Relationships between Thigh and Waist Circumference, Hemoglobin Glycation Index, and Carotid Plaque in Patients with Type 2 Diabetes

Yoon MK, Kang JG, Lee SJ, Ihm SH, Huh KB, Kim CS

Background: This study investigated the relationships of thigh and waist circumference with the hemoglobin glycation index (HGI) and carotid atherosclerosis in patients with type 2 diabetes. Methods: This observational study included...
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Risk Factors for Mortality and Respiratory Support in Elderly Patients Hospitalized with COVID-19 in Korea

Lee JY, Kim HA, Huh K, Hyun M, Rhee JY, Jang S, Kim JY, Peck KR, Chang HH

Background: The mortality risk of coronavirus disease 2019 (COVID-19) is higher in patients with older age, and many elderly patients are reported to require advanced respiratory support. Methods: We reviewed medical...
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Association between Non-Alcoholic Steatohepatitis and Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus

Lee H, Kim G, Choi YJ, Huh BW, Lee BW, Kang ES, Cha BS, Lee EJ, Lee Yh, Huh KB

Background: Impaired diastolic heart function has been observed in persons with non-alcoholic fatty liver disease (NAFLD) and/or with type 2 diabetes mellitus (T2DM). However, it is unclear whether NAFLD fibrotic...
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Pharmacokinetics and pharmacodynamics of a fixed-dose combination of gemigliptin/metformin sustained release 25/500 mg compared to the loose combination in healthy male subjects

Jin X, Kim E, Huh KY, Hwang I, Cho JY, Yu KS, Lee S

A fixed-dose combination (FDC) of gemigliptin/metformin can improve the medication adherence in patients with type 2 diabetes mellitus (T2DM). In this study, the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of...
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Graft-versus-host disease after simultaneous pancreas-kidney transplantation

Lee J, Kim MS, Huh KH, Joo DJ, Lee JG, Kim SI

Graft-versus-host disease (GVHD) is rare complication after simultaneous pancreas-kidney transplantation (SPK). Here, we present a rare case of GVHD that developed in a SPK recipient. A 38-year-old female patient with...
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Characteristics and Clinical Outcomes of Extended-Spectrum beta-lactamaseproducing Klebsiella pneumoniae Bacteremia in Cancer Patients

Nham E, Huh K, Cho SY, Chung DR, Peck KR, Lee NY, Kang CI

Background: Cancer patients can be at a higher risk of infection due to drug-resistant bacteria than the general population for various reasons. We performed a retrospective study to evaluate possible...
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Emergent Strategies for the Next Phase of COVID-19

Huh K, Shin HS, Peck KR

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The feasibility of organ transplantation during the COVID-19 outbreak: experiences from South Korea

Lee J, Kim EJ, Ihn K, Lee JG, Joo DJ, Kim MS, Kim SI, Kim YS, Huh KH

Background: The coronavirus disease 2019 (COVID-19) has forced healthcare systems to reduce transplant activities in order to preserve resources and minimize the risk of nosocomial transmission. Although transplantation societies around...
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Serum creatinine level at 1-month posttransplant can independently predict long-term graft survival and functional status

Koh SM, Ju MK, Huh KH, Kim YS, Kim MS

Background: After the year 2000, kidney transplants with high immunologic risk and deceased donors increased rapidly in Korea. At the same time, the medical community developed special pretransplant and early posttransplantation...
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Clinical impact of serum bilirubin levels on kidney transplant outcomes

Lee J, Kim EJ, Lee JG, Kim BS, Huh KH, Kim MS, Kim SI, Kim YS, Joo DJ

Background: Serum bilirubin, a potent endogenous antioxidant, has been associated with decreased risks of cardiovascular disease, diabetes, and chronic kidney disease. However, the effects of serum bilirubin on long-term kidney...
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