- Gemigliptin Inhibits Interleukin-1β–Induced Endothelial-Mesenchymal Transition via Canonical-Bone Morphogenetic Protein Pathway
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Hong OK, Lee SS, Yoo SJ, Lee MK, Kim MK, Baek KH, Song KH, Kwon HS
- KMID: 2503269
- Endocrinol Metab.
- 2020 Jun;35(2):384-395.
- doi: 10.3803/EnM.2020.35.2.384
Background: Endothelial-to-mesenchymal transition (EndMT) contributes to inflammatory conditions inducing conversion of endothelial cells (ECs) into activated fibroblasts, promoting fibrotic diseases. Pro-inflammatory cytokine is the most potent inducer of EndMT. We... -
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- The Association between Pancreatic Steatosis and Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
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Jeong JS, Kim MK, Han KD, Hong OK, Baek KH, Song KH, Chung DJ, Lee JM, Kwon HS
- KMID: 2422787
- Diabetes Metab J.
- 2018 Oct;42(5):425-432.
- doi: 10.4093/dmj.2017.0107
BACKGROUND: Whether pancreatic steatosis has a local or systemic effect, like ectopic fat of other major organs, remains unknown. Data on the influence of pancreatic steatosis on microvascular complication are... -
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- High glucose and palmitate increases bone morphogenic protein 4 expression in human endothelial cells
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Hong OK, Yoo SJ, Son JW, Kim MK, Baek KH, Song KH, Cha BY, Jo H, Kwon HS
- KMID: 2388673
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):169-175.
- doi: 10.4196/kjpp.2016.20.2.169
Here, we investigated whether hyperglycemia and/or free fatty acids (palmitate, PAL) aff ect the expression level of bone morphogenic protein 4 (BMP4), a proatherogenic marker, in endothelial cells and the... -
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- Chronic Alcohol Consumption Results in Greater Damage to the Pancreas Than to the Liver in the Rats
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Lee SS, Hong OK, Ju A, Kim MJ, Kim BJ, Kim SR, Kim WH, Cho NH, Kang MI, Kang SK, Kim DJ, Yoo SJ
- KMID: 2285573
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):309-318.
- doi: 10.4196/kjpp.2015.19.4.309
Alcohol consumption increases the risk of type 2 diabetes. However, its effects on prediabetes or early diabetes have not been studied. We investigated endoplasmic reticulum (ER) stress in the pancreas... -
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- Angiotensin II Inhibits Insulin Binding to Endothelial Cells
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Oh SJ, Ha WC, Lee JI, Sohn TS, Kim JH, Lee JM, Chang SA, Hong OK, Son HS
- KMID: 2175427
- Diabetes Metab J.
- 2011 Jun;35(3):243-247.
- doi: 10.4093/dmj.2011.35.3.243
BACKGROUND: Insulin-mediated glucose uptake in insulin target tissues is correlated with interstitial insulin concentration, rather than plasma insulin concentration. Therefore, insulin delivery to the interstitium of target tissues is very... -
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- Flow Cytometric Analysis of Cultured Adult Neural Stem Cells from Guinea Pig Spiral Ganglion
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Kim YH, Kim CH, Park KH, Park SN, Choi MY, Hong OK, Kim JH, Cho SJ, Kim JH, Chang KH, Yeo SW
- KMID: 2276985
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2009 Feb;52(2):129-133.
- doi: 10.3342/kjorl-hns.2009.52.2.129
BACKGROUND AND OBJECTIVES: To make stem cell therapy successful as one of treatment options for sensorineural hearing loss, it is essential to culture and obtain sufficient amounts of adult neural... -
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- The effects of mixed chimerism conducted by natural killer cell depletion with non myeloablation on islet allograft rejection
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Park HS, Cho SG, Park CG, Hong OK, Kim JW, Kim BR, Yoon KH
- KMID: 2331785
- J Korean Diabetes Assoc.
- 2006 Jan;30(1):54-63.
BACKGROUND: Because of the shortage of human pancreas and immunorejection, very small fraction of patients with type 1 diabetes can be treated with islet transplantation. The immune tolerance induction for... -
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- The long-term effect of ramipril on Gialpha2-protein and Protein Tyrosine Phosphatase 1B in an animal model of type 2 diabetes(OLETF rat)
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Lee JM, Hong OK, Kwon HS, Moon SD, Chang SA, Son HS, Yoon KH, Cha BY, Kang SK
- KMID: 2331782
- J Korean Diabetes Assoc.
- 2006 Jan;30(1):25-38.
BACKGROUND: The regulation of tyrosine phosphorylation/dephosphorylation is an important mechanism in various intracellular metabolism. Also impaired insulin signal transduction is important in pathogenesis of type 2 diabetes. It has been... -
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- Pancreatic Stellate Cell Activation by High Glucose and Its Effect on Angiotensin II
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Ko SH, Hong OK, Lee MK, Park EH, Lee SS, Ahn YB, Song KH, Cha BY, Son HY, Kim MJ, Jung IK, Yoon KH
- KMID: 2177758
- J Korean Diabetes Assoc.
- 2005 Jul;29(4):304-314.
BACKGROUND: Pancreatic stellate cells (PSCs) are known to be related to pancreatic inflammation and fibrosis, and are the result of extracellular matrix(ECM) protein synthesis. Recent studies have shown that blockade... -
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- Induction of Immune Tolerance by Macrochimerism: Preliminary Study for Overcome of Islet Allograft Rejection
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Hong OK, Kim SJ, Park CG, Chung CW, Kwon HS, Choi YH, Cha BY, Son HY, Yoon KH
- KMID: 2331759
- J Korean Diabetes Assoc.
- 2005 Mar;29(2):112-121.
BACKGROUND: Recently islet transplantation(TPx) has achieved remarkable results while it is not the ultimate solution yet because of a serious shortage of human pancreases, immune rejection and recurrence of autoimmunity.... -
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- Characterization of Preadipocyte factor-1 (Pref-1) Expressing Pancreatic Cells
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Rhee M, Suh SH, Yang YJ, Kim JW, Jeon SY, Hong OK, Ko SH, Choi YH, Cha BY, Son HY, Yoon KH
- KMID: 2177738
- J Korean Diabetes Assoc.
- 2005 Nov;29(6):507-516.
BACKGROUND: Preadipocyte factor-1/Delta-like 1(Pref-1/Dlk1) is a type I membrane protein that has six epidermal growth factor (EGF)-like repeats in its extracellular and a short cytoplasmic domain. It is widely expressed... -
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- The Effects of Dexamethasone on the Expansion and Transdifferentiation of Transplanted Porcine Neonatal Pancreas Cell Clusters into beta-cells in Normal Nude Mice
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Yang JH, Suh SH, Jeon SY, Hong OK, Yoon KH
- KMID: 2008164
- J Korean Diabetes Assoc.
- 2004 Oct;28(5):356-366.
BACKGROUND: Several studies have suggested that glucocorticoid has an influence on the development and function of the -cells. Thus, we undertook this study to determine whether exposure to dexamethasone... -
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- The Effects of High Glucose, Insulin and TGF-beta 1 on Proliferation and Differentiation of the Pancreatic Stellate Cells
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Hong OK, Kwon HS, Yeom KH, Lee M, Yang JH, Ko SH, Yoo SJ, Son HS, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 1768000
- J Korean Diabetes Assoc.
- 2003 Jun;27(3):228-240.
BACKGROUND: Although chronic pancreatitis gives rise to fibrosis of pancreatic exocrine tissue, and type 2 diabetes is accompanied by pancreatic fibrosis, the mechanisms of fibrogenesis in the pancreas have been... -
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- The Effect of Nitric Oxide on Insulin Binding and Insulin Receptor Recycling in Bovine Aortic Endothelial Cells
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Kwon HS, Hong OK, Kim HS, Lee JM, Kim SR, Moon SD, Jang SA, Son HS, Yoon KH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 1767999
- J Korean Diabetes Assoc.
- 2003 Jun;27(3):213-227.
BACKGROUND: The coexistence of insulin resistance and endothelial dysfunction is commonly observed in a variety of metabolic and cardiovascular disorders, including athero-sclerosis and type 2 diabetes mellitus. Because nitric oxide... -
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- Effect of Gi-proteins on Insulin Binding, Internalization and Recycling of Insulin Receptor in Bovine Aorta Endothelial Cell
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Kwon HH, Son HS, Lee JM, Ko SH, Hong OK, Moon SD, Chang SA, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 2008104
- J Korean Diabetes Assoc.
- 2003 Feb;27(1):26-38.
BACKGROUND: Guanine nucleotide binding proteins (G-proteins) play important roles in the hormonal actions of many signal transduction systems. Possible roles for the Gi-protein in insulin action have been suggested. It... -
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- 3-Dimensional Long Term Culture of Monolayer Cultured Dispersed Neonatal Porcine Pancreas Cells (NPCC)
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Suh SH, Yoon KH, Kwon HS, Hong OK, Lee JM, Song KH, Yoo SJ, Son HS, Kang MI, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 2008281
- J Korean Diabetes Assoc.
- 2002 Oct;26(5):383-395.
BACKGROUND: We have reported porcine neonatal pancreas cell clusters (NPCCs) to be useful clinical alternative due to their growth potential and convenience. However, to apply the porcine NPCCs in human... -
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- Effect of Overexpression of Gi Proteins on Insulin Actions in 3T3-L1 Adipocytes
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Son HS, Cha BY, Moon SD, Lee JM, Hong OK, Chang SA, Ahn YB, Yoon KH, Lee KW, Son HY, Kang SK
- KMID: 1905886
- J Korean Diabetes Assoc.
- 2000 Aug;24(4):404-412.
BACKGROUND: It has been reported that G proteins are involved in biological actions of insulin. Especially, Gi protein is more associated with insulin actions than Gs proteins. Gi protein has... -
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- Changes in the Amount and Function of Gi Protein in the Liver Cells of Streptozotocin-Induced Diabetic Rats
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Ock SM, Son HS, Hong OK, Lee JM, Kim SR, Chang SA, Yoon KH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 1767982
- J Korean Diabetes Assoc.
- 2000 Dec;24(6):666-677.
BACKGROUND: The functional and expressional changes of Gi proteins in diabetes have been investigated extensively, no agreement has been reached in the results. Moreover, studies using rats with different diabetic... -
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- The Formation of Multimedia Medical Information Web DB by Frequent Q and A in Internet Hospital
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Hong OJ, Park SI, Choi KC, Park SN, Kim SJ, Suh SW, Kim SH, Hwang JH, Kim YB, Park HM
- KMID: 2329802
- J Korean Soc Med Inform.
- 1999 Dec;5(3):159-167.
Over Past years people have known rich medical information and knowledge through mass-media. It is needed to develop medical database, which makes people get proper medical information, So we made... -
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- Medical Counseling by Interact via Daily Newspaper
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Kim YB, Hong OJ, Han SH, Choi KC, Park SN, Lee SM, Ha KC, La DG
- KMID: 2329731
- J Korean Soc Med Inform.
- 1998 Jun;4(1):57-63.
Recently the change in medical informatics enabled us to use medical information whenever we want and wherever we are. There are many homepages on the web, which provide hospital information,... -
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