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Implementation and Validation of a Gas Chromatography-Mass Spectrometry Method for Pristanic Acid and Phytanic Acid Quantification in Plasma Specimens

Yi A, Lee JH, Yoo G, Lim HJ, Park E, Han J, Kim GY, Cho SE, Lee SG, Lee EH

We validated a gas chromatography-mass spectrometry (GC-MS) method for quantifying pristanic acid (PrA) and phytanic acid (PhA) in plasma specimens. We developed a GC-MS method based on the analysis of 20...
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Comparison of clinicopathological characteristics and prognosis in breast cancer patients with different Breast Imaging Reporting and Data System categories

Kim BK, Ryu JM, Oh SJ, Han J, Choi JE, Jeong J, Suh YJ, Lee J, Sun WY, Korean Breast Cancer Society

Purpose: The Breast Imaging Reporting and Data System (BI-RADS) is a systematic and standardized scheme of the radiological findings of breast. However, there were different BI-RADS categories between breast cancers...
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Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy

Bae Y, Lee J, Kho C, Choi JS, Han J

In this study, we aimed to synthesize PAMAMG3 derivatives (PAMAMG3-KRRR and PAMAMG3-HKRRR), using KRRR peptides as a nuclear localization signal and introduced histidine residues into the KRRR-grafted PAMAMG3 for delivering...
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Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders

Han YH, Lee K, Saha A, Han J, Choi H, Noh M, Lee YH, Lee MO

Uncontrolled inflammation is considered the pathophysiological basis of many prevalent metabolic disorders, such as nonalcoholic fatty liver disease, diabetes, obesity, and neurodegenerative diseases. The inflammatory response is a self-limiting process...
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Optical Coherence Tomography Findings Facilitate the Diagnosis of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay

Cho H, Lyoo CH, Park SE, Seo Y, Han SH, Han J

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MiR-181a Promotes Spermatogenesis by Targeting the S6K1 Pathway

Wang L, Sun J, Han J, Ma Z, Pan M, Du Z

Approximately 15% of couples suffer from infertility worldwide, and male factors contribute to about 30% of total sterility cases. However, there is little progress in treatments due to the obscured...
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PLGA Microspheres Containing Hydrophobically Modified Magnesium Hydroxide Particles for Acid NeutralizationMediated Anti-Inflammation

Kim JK, Go EJ, Ko KW, Oh HJ, Han J, Han DK, Park W

BACKGROUND: Poly(lactic-co-glycolic acid) (PLGA) microspheres have been actively used in various pharmaceutical formulations because they can sustain active pharmaceutical ingredient release and are easy to administer into the body using...
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Radiologic Approach for Pulmonary Vasculitis

Kim C, Kim YK, Han J

Vasculitis is a systemic disease, characterized by inflammation of the vascular wall. Although rare, it is sometimes life-threatening due to diffuse pulmonary hemorrhage or acute glomerulonephritis. Besides primary vasculitis, whose...
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C-kit-negative Extragastrointestinal Stromal Tumor Originating in the Mesentery Misdiagnosed as an Ovarian Tumor before Surgery

Lim J, Baeg MK, Ahn S, Ha MH, Ko SH, Kwon H, Han J

Gastrointestinal stromal tumors (GISTs) are rare digestive system malignancies with extragastrointestinal stromal tumors (EGISTs) being even less. Diagnosing GISTs usually requires the identification of c-kit (CD117) expression by immunohistochemical staining....
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Surgical Outcomes of Revision Operation for Non-Cholesteatomatous Chronic Otitis Media

Han J, Lee J, Hong SK, Lee HJ, Kim HJ

Background and Objectives The aim of this study was to investigate the surgical outcomes of revision operation due to recurrence of non-cholesteatomatous chronic otitis media (COM) surgery cases. Subjects and Method...
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Hydrogen sulfide restores cardioprotective effects of remote ischemic preconditioning in aged rats via HIF-1α/Nrf2 signaling pathway

Wang H, Shi X, Cheng L, Han J, Mu J

The present study explored the therapeutic potential of hydrogen sulfide (H2 S) in restoring aging-induced loss of cardioprotective effect of remote ischemic preconditioning (RIPC) along with the involvement of signaling...
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Imaging Assessment of Visceral Pleural Surface Invasion by Lung Cancer: Comparison of CT and Contrast-Enhanced Radial T1-Weighted Gradient Echo 3-Tesla MRI

Zhang Y, Kwon W, Lee HY, Ko SM, Kim SH, Lee WY, Yong SJ, Jung SH, Byun CS, Lee J, Yang H, Han J, Ackman JB

Objective: To compare the diagnostic performance of contrast-enhanced radial T1-weighted gradient-echo 3-tesla (3T) magnetic resonance imaging (MRI) and computed tomography (CT) for the detection of visceral pleural surface invasion (VPSI)....
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Phosphorylation in Novel Mitochondrial Creatine Kinase Tyrosine Residues Render Cardioprotection against Hypoxia/Reoxygenation Injury

Park N, Marquez J, Garcia MVF, Shimizu I, Lee SR, Kim HK, Han J

Objective: Ischemic cardiomyopathy (ICM) is the leading cause of heart failure. Proteomic and genomic studies have demonstrated ischemic preconditioning (IPC) can assert cardioprotection against ICM through mitochondrial function regulation. Considering...
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Spectrum of Pulmonary Fibrosis from Interstitial Lung Abnormality to Usual Interstitial Pneumonia: Importance of Identification and Quantification of Traction Bronchiectasis in Patient Management

Hino T, Lee KS, Han J, Hata A, Ishigami K, Hatabu H

Following the introduction of a novel pathological concept of usual interstitial pneumonia (UIP) by Liebow and Carrington in 1969, diffuse interstitial pneumonia has evolved into UIP, nonspecific interstitial pneumonia (NSIP),...
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Difficult Biliary Cannulation from the Perspective of PostEndoscopic Retrograde Cholangiopancreatography Pancreatitis: Identifying the Optimal Timing for the Rescue Cannulation Technique

Lee YS, Cho CM, Cho KB, Heo J, Jung MK, Kim SB, Kim KH, Kim TN, Lee DW, Han J, Kim HG, Kim D, Kim H

Background/Aims: Recently, the European Society of Gastrointestinal Endoscopy (ESGE) proposed criteria for “difficult biliary cannulation” during endoscopic retrograde cholangiopancreatography (ERCP). This study aimed to investigate the clinical relevance of the...
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Breast Cancer Statistics in Korea, 2018

Kang SY, Lee SB, Kim YS, Kim Z, Kim HY, Kim HJ, Park S, Bae SY, Yoon K, Lee SK, Jung KW, Han J, Youn HJ, Korean Breast Cancer Society

Breast cancer is the most common malignancy in Korean women, and its incidence continues to increase. The Korean Breast Cancer Society (KBCS) established a nationwide breast cancer database through its...
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A Case with Multiple Fungal Coinfections in a Patient who Presented with Pancoast Syndrome

Jin H, Kim D, Choi Js, Huh HJ, Lee NY, Han J, Cho HW, Ma Y, Jeon TY, Yoo SY, Yoo KH, Koo HH, Kim YJ

Invasive fungal infection (IFI) is a serious threat to pediatric patients with cancer given high morbidity and mortality. We present an 18-year-old male with precursor T-cell lymphoblastic leukemia who developed...
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Xanthogranulomatous Cholecystitis Suspected as Metastatic Gallbladder Cancer

Han J, Ahn S, Cho IR

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Elucidating molecular mechanisms of acquired resistance to BRAF inhibitors in melanoma using a microfluidic device and deep sequencing

Han J, Jung Y, Jun Y, Park S, Lee S

BRAF inhibitors (e.g., vemurafenib) are widely used to treat metastatic melanoma with the BRAF V600E mutation. The initial response is often dramatic, but treatment resistance leads to disease progression in...
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Far-infrared rays enhance mitochondrial biogenesis and GLUT3 expression under low glucose conditions in rat skeletal muscle cells

Seo Y, Kim YW, Lee D, Kim D, Kim K, Kim T, Baek C, Lee Y, Lee J, Lee H, Jang G, Jeong W, Choi J, Hwang D, Suh JS, Kim SW, Kim HK, Han J, Bang H, Kim JH, Zhou T, Ko JH

Far-infrared rays (FIR) are known to have various effects on atoms and molecular structures within cells owing to their radiation and vibration frequencies. The present study examined the effects of...
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