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Examining Patterns of Polypharmacy in Bipolar Disorder: Findings from the REAP-BD, Korea

Kim K, Yang H, Na E, Lee H, Jang OJ, Yoon HJ, Oh HS, Ham BJ, Park SC, Lin SK, Tan CH, Shinfuku N, Park YC

Based on Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar Disorder, this study tried to present prescription patterns in biopolar disorder (BD) and its associated clinical...
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Morphologic Alterations in Amygdala Subregions of Adult Patients with Bipolar Disorder

Lee HJ, Han KM, Kim A, Kang W, Kang Y, Kang J, Won E, Tae WS, Ham BJ

OBJECTIVES: Previous studies have revealed inconsistent results on amygdala volume in adult bipolar disorder (BD) patients compared to healthy controls (HC). Since the amygdala encompasses multiple subregions, the subtle volume...
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Erratum: Morphologic Alterations in Amygdala Subregions of Adult Patients with Bipolar Disorder

Lee HJ, Han KM, Kim A, Kang W, Kang Y, Kang J, Won E, Tae WS, Ham BJ

There is an error in Table 5.
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Changes in the Volume and Cortical Thickness of the Specific Regions of Cerebellum of Patients with Major Depressive Disorder

Kang JW, Han KM, Won E, Tae WS, Ham BJ

OBJECTIVES: A growing body of evidence has suggested that morphologic changes in cerebellum may be implicated with pathophysiology of major depressive disorder (MDD). The aim of this study is to...
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Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders

Tae WS, Ham BJ, Pyun SB, Kang SH, Kim BJ

Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the structure of white matter. The signal contrast in DTI is generated by differences in the Brownian motion...
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Alterations of Cortical Folding Patterns in Patients with Bipolar I Disorder: Analysis of Local Gyrification Index

Lee J, Han KM, Won E, Lee MS, Ham BJ

OBJECTIVES: Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. Several studies have suggested altered local gyrification in...
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Associations between Vasomotor Symptoms and Depression, Stress and Quality of Life in Midlife Women

Nam YM, Joe SH, Kwon EJ, Ham BJ, Han CS, Ko YH

OBJECTIVES: The aim of this study was to evaluate the associations between vasomotor symptoms and factors such as sociodemographics, health behaviors, medical condition, depression, stress, anxiety, attitude toward menopause, and...
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Association between the Alu Insertion/Deletion Polymorphism in the Tissue-Type Plasminogen Activator Gene and Mirtazapine Response in Koreans with Major Depression

Kim D, Chang HS, Won E, Ham BJ, Lee MS

OBJECTIVES: To determine the relationship between the Alu insertion/deletion (I/D) polymorphism in the tissue-type plasminogen activator (tPA) gene and the clinical outcome of mirtazapine treatment in Korean major depressive disorder...
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Frontoparietal Cortical Thinning in Respiratory-Type Panic Disorder: A Preliminary Report

Yoon HK, Kang J, Kwon DY, Ham BJ

OBJECTIVE: Many evidences raise the possibility that the panic disorder (PD) patients with respiratory subtype (RS) may have characteristic structural abnormalities. We aimed to explore the structural differences between PD...
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Fatigue and Its Association with Socio-Demographic and Clinical Variables in a Working Population

Park S, Joe SH, Kim SH, Han CS, Ham BJ, Ko YH

  • KMID: 1737052
  • Korean J Psychosom Med.
  • 2014 Jun;22(1):3-12.
OBJECTIVES: We aimed to explore the relationship among fatigue and perceived stress, depressive mood in the working population. We also examined associations with demographic and life style factors and investigated...
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Evidence-Based, Pharmacological Treatment Guideline for Depression in Korea, Revised Edition

Won E, Park SC, Han KM, Sung SH, Lee HY, Paik JW, Jeon HJ, Lee MS, Shim SH, Ko YH, Lee KJ, Han C, Ham BJ, Choi J, Hwang TY, Oh KS, Hahn SW, Park YC, Lee MS

This paper aims to introduce, summarize, and emphasize the importance of the 'Evidence-Based, Pharmacological Treatment Guideline for Depression in Korea, Revised Edition'. The guideline broadly covers most aspects of the...
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A Meta-Analysis Comparing Open-Label versus Placebo- Controlled Clinical Trials for Aripiprazole Augmentation in the Treatment of Major Depressive Disorder: Lessons and Promises

Pae CU, Seo HJ, Lee BC, Seok JH, Jeon HJ, Paik JW, Kwak KP, Ham BJ, Han C, Lee SJ

OBJECTIVE: The present study is to provide whether open-label studies (OLS) may properly foresee the efficacy of randomized, placebo-controlled trials (RCTs) using OLSs and RCTs data for aripiprazole in the...
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Variables Influencing Subjective Well-Being in Patients with Schizophrenia

Oh J, Ko YH, Paik JW, Lee MS, Han C, Jeong HG, Ham BJ, Kim YK, Kim SH

OBJECTIVES: The purpose of this study was to analyze the relationship between subjective well-being and other clinical parameters such as sociodemographic and clinical variables, which include positive and negative symptoms,...
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Evidence-Based Korean Pharmacological Treatment Guideline for Depression, Revised Edition (III) : Dose Increment, Switching, Combination, and Augmentation Strategy in Antidepressant Therapy

Han KM, Park SC, Won ES, Sung SH, Lee H, Koo JW, Lee K, Lee HY, Paik JW, Jeon HJ, Lee MS, Shim SH, Ko YH, Lee KJ, Han C, Ham BJ, Choi J, Hwang TY, Oh KS, Hahn SW, Park YC, Lee MS

  • KMID: 2343634
  • J Korean Neuropsychiatr Assoc.
  • 2013 Sep;52(5):386-401.
OBJECTIVES: The aim of this study was to demonstrate the recommendations for antidepressant treatment strategy of dose increment, switching, combination, and augmentation therapy derived from Evidence-Based Korean Pharmacological Treatment Guideline...
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Evidence-Based Korean Pharmacological Treatment Guideline for Depression, Revised Edition (II) : Antidepressant Efficacy Compared with Placebo, Difference in Efficacy of Antidepressants, and Appropriate Time of Efficacy Judgment in Antidepressant Therapy

Sung SH, Park SC, Han KM, Won ES, Lee HY, Koo JW, Paik JW, Lee KM, Jeon HJ, Lee MS, Shim SH, Ko YH, Lee KJ, Han C, Ham BJ, Choi J, Hwang TY, Oh KS, Park YC, Lee MS, Hahn SW

  • KMID: 2343633
  • J Korean Neuropsychiatr Assoc.
  • 2013 Sep;52(5):372-385.
OBJECTIVES: The purpose of this study was to suggest recommendations of antidepressant efficacy compared with placebo, difference in efficacy of antidepressants, and appropriate time of efficacy judgment in antidepressant therapy. METHODS:...
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Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder

Kim JW, Kim YK, Hwang JA, Yoon HK, Ko YH, Han C, Lee HJ, Ham BJ, Lee HS

  • KMID: 2316303
  • Psychiatry Investig.
  • 2013 Sep;10(3):294-299.
OBJECTIVE: Cytokines are believed to have a role in the pathophysiology of major depression. The alteration in levels of pro-inflammatory cytokines [interleukin 1beta (IL-1beta), IL-2, IL-6, IL-12, interferon gamma, and...
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CYP2D6 P34S Polymorphism and Outcomes of Escitalopram Treatment in Koreans with Major Depression

Han KM, Chang HS, Choi IK, Ham BJ, Lee MS

  • KMID: 2316302
  • Psychiatry Investig.
  • 2013 Sep;10(3):286-293.
OBJECTIVE: Cytochrome P450 (CYP) enzymatic activity, which is influenced by CYP genetic polymorphism, is known to affect the inter-individual variation in the efficacy and tolerability of antidepressants in major depressive...
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Evidence-Based Korean Pharmacological Treatment Guideline for Depression, Revised Edition (I) : Initial Choice of Antidepressant Treatment

Park SC, Sung SH, Han KM, Won ES, Lee HY, Paik JW, Jeon HJ, Lee MS, Shim SH, Ko YH, Lee KJ, Han C, Ham BJ, Choi J, Lee H, Hwang TY, Oh KS, Park YC, Lee MS, Hahn SW

  • KMID: 2343589
  • J Korean Neuropsychiatr Assoc.
  • 2013 Jul;52(4):253-262.
OBJECTIVES: The aim of this study is to establish Korean pharmacological treatment guidelines for the initial choice of antidepressant for treatment of moderate or severe depression. METHODS: The process for establishment...
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Stress and mental illness

Lee HY, Ham BJ

  • KMID: 2342261
  • J Korean Med Assoc.
  • 2013 Jun;56(6):471-477.
Suicide is a significant public health issue and a major cause of death in Korea. Almost 95% of all persons who commit or attempt suicide have a diagnosed mental disorder....
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No Association between Serotonin Receptor 2C-759C/T Polymorphism and Weight Change or Treatment Response to Mirtazapine in Korean Depressive Patients

Lee HY, Oh CK, Ham BJ, Chang HS, Paik JW, Won ES, Hahn SW, Shim SH, Kwon YJ, Jung HY, Lee MS

  • KMID: 2316267
  • Psychiatry Investig.
  • 2013 Jun;10(2):190-195.
OBJECTIVE: Activation of one or more serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of serotonergic antidepressants. The serotonin 2C (5HT 2C) receptor is known to...
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