- Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells
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Kim HJ, Gong MK, Yoon CY, Kang J, Yun M, Cho NH, Rha SY, Choi YD
- KMID: 2503353
- Yonsei Med J.
- 2020 Jul;61(7):587-596.
- doi: 10.3349/ymj.2020.61.7.587
Purpose: The current study aimed to investigate the synergistic antitumor effect of combined treatment with 17-DMAG (HSP90 inhibitor) and NVP-BEZ235 (PI3K/mTOR dual inhibitor) on cisplatin-resistant human bladder cancer cells. Materials and... -
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- A Case of Ischemic Stroke in Young Patient Associated with Marijuana Use
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Ha SY, Kang DW, Lee SH
- KMID: 2503753
- J Korean Soc Clin Toxicol.
- 2020 Jun;18(1):47-50.
- doi: 10.22537/jksct.2020.18.1.47
A 21-year-old female patient complaining of hemiparesis was diagnosed with right middle cerebral artery infarction. No risk factor was found, despite an extensive young-age stroke work-up, except her history of... -
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- Carcinoembryonic Antigen Improves the Performance of MagneticResonance Imaging in the Prediction of Pathologic Response afterNeoadjuvant Chemoradiation for Patients with Rectal Cancer
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Yoo GS, Park HC, Yu JI, Choi DH, Cho WK, Park YS, Park JO, Lim HY, Kang WK, Lee WY, Kim HC, Yun SH, Cho YB, Park YA, Song KD, Kim SH, Ha SY
- KMID: 2500330
- Cancer Res Treat.
- 2020 Apr;52(2):446-454.
- doi: 10.4143/crt.2019.261
Purpose The purpose of this study was to investigate the role of carcinoembryonic antigen (CEA) levels in improving the performance of magnetic resonance imaging (MRI) for the prediction of pathologic response after the... -
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- Comparison of Mac-2 Binding Protein Glycosylation Isomer, Fibroscan, and Other Fibrosis Markers for Assessing Liver Cirrhosis in Patients with Chronic Hepatitis B Virus-mediated Hepatocellular Carcinoma
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Lee K, Yoo IY, Joh JW, Kim JM, Gwak GY, Sinn DH, Ha SY, Kang ES, Park HD
- KMID: 2512240
- Lab Med Online.
- 2020 Apr;10(2):109-115.
- doi: 10.3343/lmo.2020.10.2.109
Background Liver cirrhosis is advanced stage of hepatic brosis caused by viral hepatitis. Mac-2 binding protein glycosylation isomer (M2BPGi) is a serum marker to diagnose and evaluate hepatic brosis progression. In... -
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- Comparison of papanicolaou smear and human papillomavirus (HPV) test as cervical screening tools: can we rely on HPV test alone as a screening method? An 11-year retrospective experience at a single institution
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Kang M, Ha SY, Cho HY, Chung DH, Kim NR, An J, Lee S, Seok JY, Jeong J
- KMID: 2501599
- J Pathol Transl Med.
- 2020 Jan;54(1):112-118.
- doi: 10.4132/jptm.2019.11.29
Background: The decrease in incidence of cervical dysplasia and carcinoma has not been as dramatic as expected with the development of improved research tools and test methods. The human papillomavirus... -
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- Behaviors and Attitudes toward the Use of Complementary and Alternative Medicine among Korean Cancer Patients
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Kwon JH, Lee SC, Lee MA, Kim YJ, Kang JH, Kim JY, Lee HJ, Bae WK, Kim MJ, Chie EK, Kim J, Kim YH, Chung HC, Rha SY
- KMID: 2454278
- Cancer Res Treat.
- 2019 Jul;51(3):851-860.
- doi: 10.4143/crt.2019.137
PURPOSE: A cross-sectional survey was conducted to explore the current awareness and use of complementary and alternative medicine (CAM), as well as attitudes toward CAM, in patients with cancer and... -
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- Significance of Metabolic Tumor Volume and Total Lesion Glycolysis Measured Using ¹â¸F-FDG PET/CT in Locally Advanced and Metastatic Gallbladder Carcinoma
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Chun YJ, Jeung HC, Park HS, Park JS, Rha SY, Choi HJ, Lee JH, Jeon TJ
- KMID: 2450399
- Yonsei Med J.
- 2019 Jul;60(7):604-610.
- doi: 10.3349/ymj.2019.60.7.604
PURPOSE: This study aimed to determine the prognostic value of new quantitative parameters of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), including metabolic tumor volume (MTV), in patients with locally... -
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- Immunohistochemistry Biomarkers Predict Survival in Stage II/III Gastric Cancer Patients: From a Prospective Clinical Trial
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Kim MH, Zhang X, Jung M, Jung I, Park HS, Beom SH, Kim HS, Rha SY, Kim H, Choi YY, Son T, Kim HI, Cheong JH, Hyung WJ, Noh SH, Chung HC
- KMID: 2464427
- Cancer Res Treat.
- 2019 Apr;51(2):819-831.
- doi: 10.4143/crt.2018.331
PURPOSE: Identification of biomarkers to predict recurrence risk is essential to improve adjuvant treatment strategies in stage II/III gastric cancer patients. This study evaluated biomarkers for predicting survival after surgical... -
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- Intraoperative Frozen Cytology of Central Nervous System Neoplasms: An Ancillary Tool for Frozen Diagnosis
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Kang M, Chung DH, Kim NR, Cho HY, Ha SY, Lee S, An J, Seok JY, Yie GT, Yoo CJ, Lee SG, Kim EY, Kim WK, Son S, Sym SJ, Shin DB, Hwang HY, Kim EY, Lee KC
- KMID: 2465449
- J Pathol Transl Med.
- 2019 Mar;53(2):104-111.
- doi: 10.4132/jptm.2018.11.10
BACKGROUND: Pathologic diagnosis of central nervous system (CNS) neoplasms is made by comparing light microscopic, immunohistochemical, and molecular cytogenetic findings with clinicoradiologic observations. Intraoperative frozen cytology smears can improve the... -
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- Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma
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Lee JB, Park HS, Park S, Lee HJ, Kwon KA, Choi YJ, Kim YJ, Nam CM, Cho NH, Kang B, Chung HC, Rha SY
- KMID: 2460606
- Cancer Res Treat.
- 2019 Oct;51(4):1578-1588.
- doi: 10.4143/crt.2018.671
PURPOSE: Temsirolimus is effective in the treatment for metastatic non-clear cell renal cell carcinoma (nccRCC) with poor prognosis. We aim to investigate the efficacy and tolerability of temsirolimus in treatment... -
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- Characteristics and Treatment Patterns of Patients with Advanced Soft Tissue Sarcoma in Korea
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Kim HS, Nam CM, Jang SY, Choi SK, Han M, Kim S, Moneta MV, Lee SY, Cho JM, Novick D, Rha SY
- KMID: 2460587
- Cancer Res Treat.
- 2019 Oct;51(4):1380-1391.
- doi: 10.4143/crt.2018.476
PURPOSE: A soft tissue sarcoma (STS) is a rare type of cancer, accounting for 1% of adult solid cancers. The aim of the present study is to determine the incidence... -
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- Pivotal Role of Subcortical Structures as a Network Hub in Focal Epilepsy: Evidence from Graph Theoretical Analysis Based on Diffusion-Tensor Imaging
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Park KM, Lee BI, Shin KJ, Ha SY, Park J, Kim SE, Kim SE
- KMID: 2451147
- J Clin Neurol.
- 2019 Jan;15(1):68-76.
- doi: 10.3988/jcn.2019.15.1.68
BACKGROUND AND PURPOSE: There is accumulating evidence that epilepsy is caused by network dysfunction. We evaluated the hub reorganization of subcortical structures in patients with focal epilepsy using graph theoretical... -
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- Landscape of Actionable Genetic Alterations Profiled from 1,071 Tumor Samples in Korean Cancer Patients
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Lee SH, Lee B, Shim JH, Lee KW, Yun JW, Kim SY, Kim TY, Kim YH, Ko YH, Chung HC, Yu CS, Lee J, Rha SY, Kim TW, Jung KH, Im SA, Moon HG, Cho S, Kang JH, Kim J, Kim SK, Ryu HS, Ha SY, Kim JI, Chung YJ, Kim C, Kim HL, Park WY, Noh DY, Park K
- KMID: 2437614
- Cancer Res Treat.
- 2019 Jan;51(1):211-222.
- doi: 10.4143/crt.2018.132
PURPOSE: With the emergence of next-generation sequencing (NGS) technology, profiling a wide range of genomic alterations has become a possibility resulting in improved implementation of targeted cancer therapy. In Asian... -
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- S-1 Based Doublet as an Adjuvant Chemotherapy for Curatively Resected Stage III Gastric Cancer: Results from the Randomized Phase III POST Trial
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Lee CK, Jung M, Kim HS, Jung I, Shin DB, Kang SY, Zang DY, Kim KH, Lee MH, Kim BS, Lee KH, Cheong JH, Hyung WJ, Noh SH, Chung HC, Rha SY
- KMID: 2437593
- Cancer Res Treat.
- 2019 Jan;51(1):1-11.
- doi: 10.4143/crt.2018.028
PURPOSE: We conducted a randomized, multicenter, phase III trial to compare S-1 plus docetaxel (DS) with S-1 plus cisplatin (SP) as adjuvant chemotherapy for stage III gastric cancer patients. MATERIALS AND... -
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- CpG Island Methylator Phenotype and Methylation of Wnt Pathway Genes Together Predict Survival in Patients with Colorectal Cancer
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Kim SH, Park KH, Shin SJ, Lee KY, Kim TI, Kim NK, Rha SY, Ahn JB
- KMID: 2412649
- Yonsei Med J.
- 2018 Jul;59(5):588-594.
- doi: 10.3349/ymj.2018.59.5.588
PURPOSE: Dysregulation of the Wnt pathway is a crucial step in the tumorigenesis of colorectal cancer (CRC). This study aimed to determine whether DNA methylation of Wnt pathway genes helps... -
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- Pazopanib for the Treatment of Non-clear Cell Renal Cell Carcinoma: A Single-Arm, Open-Label, Multicenter, Phase II Study
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Jung KS, Lee SJ, Park SH, Lee JL, Lee SH, Lim JY, Kang JH, Lee S, Rha SY, Lee KH, Kim HY, Lim HY
- KMID: 2411137
- Cancer Res Treat.
- 2018 Apr;50(2):488-494.
- doi: 10.4143/crt.2016.584
PURPOSE: The optimal treatment strategy for patients with metastatic non-clear cell type renal cell carcinoma (nccRCC) remains unclear. Although several inhibitors of vascular endothelial growth factor have recently shown efficacy... -
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- Retrospective analysis of palliative chemotherapy for the patients with bladder adenocarcinoma: Korean Cancer Study Group Genitourinary and Gynecology Cancer Committee
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Kim MJ, Kim YS, Oh SY, Lee S, Choi YJ, Seol YM, Park MJ, Kim KH, Park LC, Kang JH, Hwang IG, Lee SI, Lim ST, Kim HS, Lim HY, Rha SY, Kim HJ
- KMID: 2411550
- Korean J Intern Med.
- 2018 Mar;33(2):383-390.
- doi: 10.3904/kjim.2015.162
BACKGROUND/AIMS: Because of rarity, role of chemotherapy of bladder adenocarcinoma are still unidentified. Therefore, we performed a retrospective analysis of the clinical features and chemotherapy outcomes of bladder adenocarcinoma. METHODS: Eligible... -
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- Prognostic Utility of Histological Growth Patterns of Colorectal Lung Oligometastasis
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Yeong SJ, Pak MG, Lee HW, Ha SY, Roh MS
- KMID: 2408510
- J Pathol Transl Med.
- 2018 Mar;52(2):98-104.
- doi: 10.4132/jptm.2017.12.27
BACKGROUND: Patients with resectable colorectal lung oligometastasis (CLOM) demonstrate a heterogeneous oncological outcome. However, the parameters for predicting tumor aggressiveness have not yet been fully investigated in CLOM. This study... -
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- Medullary Infarction Presenting as Sudden Cardiac Arrest: Report of Two Cases and Review of the Literature
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Lee EJ, Choo IY, Ha SY, Kwon HM
- KMID: 2435840
- J Korean Neurol Assoc.
- 2018 Nov;36(4):310-313.
- doi: 10.17340/jkna.2018.4.6
The causes of sudden death after medullary infarction involve arrhythmia, central respiratory failure, and dysautonomia. Sudden cardiac arrest in a medullary infarction is uncommon. Most of these cases experienced sudden... -
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- Genetic Alterations among Korean Melanoma Patients Showing Tumor Heterogeneity: A Comparison between Primary Tumors and Corresponding Metastatic Lesions
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Lee SH, Kim JE, Jang HS, Park KH, Oh BH, Shin SJ, Chung KY, Roh MR, Rha SY
- KMID: 2424809
- Cancer Res Treat.
- 2018 Oct;50(4):1378-1387.
- doi: 10.4143/crt.2017.535
PURPOSE: Melanoma is a highly heterogeneous neoplasm, composed of subpopulations of tumor cells with distinct molecular and biological phenotypes and genotypes. In this study, to determine the genetic heterogeneity between... -
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