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Breast implant–associated anaplastic large cell lymphoma: the first South Korean case

Lee J, Cho H, Yoon DH, Kim EK, Gong G, Suh C, Huh Jr

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The Usefulness of Periareolar Zigzag Incision in Breast Conserving-Surgery in Breast Cancer Patients: Experience in a Single Institution

Lim SJ, Kim HJ, Chung IY, Kim JS, Lee SB, Lee JW, Son BH, Ahn SH, Kim HH, Kim SB, Gong GY, Ko BS

Purpose: Various incision techniques have been used in breast-conserving surgery (BCS) to reduce scar formation, including the frequently used periareolar incision technique. However, its applicability in removing large-size tumors or...
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Recurrence of Breast Carcinoma as Paget's Disease of the Skin along the Core Needle Biopsy Tract after Skin-Sparing Mastectomy

Choi S, Kim EK, Kong J, Gong G, Shin HJ, Lee YJ, Son BH, Ahn SH, Lee JW

We report a case of recurrence as Paget's disease at the core needle biopsy (CNB) entry site in a patient with microinvasive ductal carcinoma who underwent nipple-areola-skin sparing mastectomy (NASSM)...
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Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas

Shin J, Kim HJ, Kim DY, Gong G, Cho KJ

BACKGROUND: Primary breast sarcoma (PBS) is rare, comprising approximately 1% of breast malignancies. Rhabdomyosarcoma (RMS) accounts for an extremely small proportion of PBSs, often leading to delayed histologic confirmation. METHODS: Upon...
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Prediction of Late Breast Cancer-Specific Mortality in Recurrence-Free Breast Cancer Survivors Treated for Five Years with Tamoxifen

Baek SY, Kwon JY, Lee YJ, Gwark SC, Lee SB, Kim J, Chung IY, Ko BS, Kim HJ, Kim SB, Ahn SD, Gong G, Son BH, Ahn SH, Lee JW

PURPOSE: The extension of endocrine therapy beyond 5 years for recurrence-free survivors of breast cancer improves survival; however, the issue on how to clinically identify appropriate candidates remains controversial. This...
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Association between p53 Expression and Amount of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer

Lee M, Park IA, Heo SH, Kim YA, Gong G, Lee HJ

BACKGROUND: Most triple-negative breast cancers (TNBCs) have a high histologic grade, are associated with high endoplasmic stress, and possess a high frequency of TP53 mutations. TP53 missense mutations lead to...
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Salivary Duct Cancer Metastasis Mimicking Primary Breast Cancer: A Case Report and Review

Alzuhair A, Gong G, Shin HJ, Lee JW, Lee SB, Kim J, Ko BS, Son BH, Ahn SH, Chung IY

Secondary breast malignancy is a rare occurrence, accounting for less than 2% of all breast malignancies. Salivary duct carcinoma (SDC) metastasizing to the breast has not been reported previously. This...
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BioPATH: A Biomarker Study in Asian Patients with HER2+ Advanced Breast Cancer Treated with Lapatinib and Other Anti-HER2 Therapy

Kim SB, Do IG, Tsang J, Kim TY, Yap YS, Cornelio G, Gong G, Paik S, Lee S, Ng TY, Park S, Oh HS, Chiu J, Sohn J, Lee M, Choi YJ, Lee EM, Park KH, Nathaniel , Ro J

PURPOSE: BioPATH is a non-interventional study evaluating the relationship of molecular biomarkers (PTEN deletion/downregulation, PIK3CA mutation, truncated HER2 receptor [p95HER2], and tumor HER2 mRNA levels) to treatment responses in Asian...
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Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers

Lee M, Song IH, Heo SH, Kim YA, Park IA, Bang WS, Park HS, Gong G, Lee HJ

PURPOSE: In the presence of interferon, proteasome subunits are replaced by their inducible counterparts to form an immunoproteasome (IP) plays a key role in generation of antigenic peptides presented by...
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FcrR3A-158 Polymorphism and Stromal Tumor-Infiltrating Lymphocytes and Survival among Patients with Metastatic HER2-Positive Breast Cancer Receiving Trastuzumab-Based Treatment

Chae H, Yoo C, Yoon JA, Lee HJ, Kim KP, Kim JE, Ahn JH, Jung KH, Gong G, Kim SB

PURPOSE: The prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer has markedly improved since the introduction of trastuzumab. We aimed to evaluate the association between stromal tumor-infiltrating...
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No Association of Positive Superficial and/or Deep Margins with Local Recurrence in Invasive Breast Cancer Treated with Breast-Conserving Surgery

Yoon TI, Lee JW, Lee SB, Sohn G, Kim J, Chung IY, Kim HJ, Ko BS, Son BH, Gong G, Kim SB, Kim SS, Ahn SD, Chung M, Ahn SH

PURPOSE: We evaluated the effect of positive superficial and/or deep margin status on local recurrence (LR) in invasive breast cancer treated with breast-conserving surgery (BCS) followed by radiotherapy. MATERIALS AND METHODS:...
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Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer

Song IH, Heo SH, Bang WS, Park HS, Park IA, Kim YA, Park SY, Roh J, Gong G, Lee HJ

PURPOSE: The tertiary lymphoid structure (TLS) is an important source of tumor-infiltrating lymphocytes (TILs), which have a strong prognostic and predictive value in triple-negative breast cancer (TNBC). A previous study...
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Expression of Myxovirus Resistance A (MxA) Is Associated with Tumor-Infiltrating Lymphocytes in Human Epidermal Growth Factor Receptor 2 (HER2)–Positive Breast Cancers

Lee SJ, Hwang CS, Kim YK, Lee HJ, Ahn SJ, Shin N, Lee JH, Shin DH, Choi KU, Park DY, Lee CH, Huh GY, Sol MY, Lee HJ, Gong G, Kim JY, Kim A

PURPOSE: The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been determined in breast cancers. Interferons can affect T-cell activity through direct and indirect mechanisms. Myxovirus resistance A (MxA) is an...
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Ectopic Male Breast Cancer in the Perineum: A Case Report

Eom HJ, Ko BS, Song IH, Gong G, Kim HH

Ectopic breast tissue and male breast cancer are both very rare diseases with only a few reports in the literature. Here, we present the first case of ectopic male breast...
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Interobserver Variability of Ki-67 Measurement in Breast Cancer

Chung YR, Jang MH, Park SY, Gong G, Jung WH, The Korean Breast Pathology Ki-67 Study Group

BACKGROUND: As measurement of Ki-67 proliferation index is an important part of breast cancer diagnostics, we conducted a multicenter study to examine the degree of concordance in Ki-67 counting and...
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Prognostic Factors for Distant Metastasis in Patients with Locoregional Recurrence after Mastectomy

Jeong Y, Kim SS, Gong G, Lee HJ, Ahn SH, Son BH, Lee JW, Choi EK, Lee SW, Ahn SD

PURPOSE: The purpose of this study was to identify patients with high risk of distant metastasis (DM) after salvage treatment for postmastectomy locoregional recurrence (LRR). METHODS: We retrospectively reviewed 142 patients...
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A Randomized Phase II Trial of Capecitabine Plus Vinorelbine Followed by Docetaxel Versus Adriamycin Plus Cyclophosphamide Followed by Docetaxel as Neoadjuvant Chemotherapy for Breast Cancer

Yoo C, Kim SB, Ahn JH, Kim JE, Jung KH, Gong GY, Son BH, Ahn SH, Ahn SD, Kim HH, Shin HJ, Kim WK

PURPOSE: Given the promising activity of capecitabine and vinorelbine in metastatic breast cancer, this randomized phase II trial evaluated the efficacy and safety of this combination as neoadjuvant chemotherapy in...
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Characteristics of BRCA1/2 Mutation-Positive Breast Cancers in Korea: A Comparison Study Based on Multicenter Data and the Korean Breast Cancer Registry

Yu JH, Lee JW, Son BH, Kim SW, Park SK, Lee MH, Kim LS, Noh WC, Kim EK, Yoon DS, Lee J, Jung JH, Jung SS, Gong G, Ahn SH

  • KMID: 2353067
  • J Breast Cancer.
  • 2014 Jun;17(2):129-135.
PURPOSE: Mutations in BRCA genes are the main cause of hereditary breast cancer in Korea. The aim of this study was to investigate the characteristics of breast cancers involving BRCA1...
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Positive Expression of Insulin-Like Growth Factor-1 Receptor Is Associated with a Positive Hormone Receptor Status and a Favorable Prognosis in Breast Cancer

Shin SJ, Gong G, Lee HJ, Kang J, Bae YK, Lee A, Cho EY, Lee JS, Suh KS, Lee DW, Jung WH

  • KMID: 2353065
  • J Breast Cancer.
  • 2014 Jun;17(2):113-120.
PURPOSE: Insulin-like growth factor 1 receptor (IGF-1R) is commonly expressed in primary breast cancers. Understanding the role of IGF-1R signaling in the different subtypes of breast cancer is important because...
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Treatment results of breast cancer patients with locoregional recurrence after mastectomy

Jeong Y, Kim SS, Gong G, Lee HJ, Ahn SH, Son BH, Lee JW, Choi EK, Lee SW, Joo JH, Ahn SD

PURPOSE: To analyze the results of locoregional and systemic therapy in the breast cancer patients with locoregional recurrence (LRR) after mastectomy. MATERIALS AND METHODS: Seventy-one patients who received radiotherapy for isolated...
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