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Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders

Singh R, Zogg H, Wei L, Bartlett A, Ghoshal UC, Rajender S, Ro S

  • KMID: 2510059
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):19-34.
  • doi: 10.5056/jnm20149
Of all microorganisms in the human body, the largest and most complex population resides in the gastrointestinal (GI) tract. The gut microbiota continuously adapts to the host environment and serves...
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The Practice of Gastrointestinal Motility Laboratory During COVID-19 Pandemic: Position Statements of the Asian Neurogastroenterology and Motility Association (ANMA-GML-COVID-19 Position Statements)

Siah KTH, Rahman MM, Ong AML, Soh AYS, Lee YY, Xiao Y, Sachdeva S, Jung KW, Wang YP, Oshima T, Patcharatrakul T, Tseng PH, Goyal O, Pang J, Lai CKC, Park JH, Mahadeva S, Cho YK, Wu JCY, Ghoshal UC, Miwa H

  • KMID: 2503998
  • J Neurogastroenterol Motil.
  • 2020 Jul;26(3):299-310.
  • doi: 10.5056/jnm20107
During the Coronavirus Disease 2019 (COVID-19) pandemic, practices of gastrointestinal procedures within the digestive tract require special precautions due to the risk of contraction of severe acute respiratoy syndrome coronavirus-2...
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2019 Seoul Consensus on Esophageal Achalasia Guidelines

Jung HK, Hong SJ, Lee OY, Pandolfino J, Park H, Miwa H, Ghoshal UC, Mahadeva S, Oshima T, Chen M, Chua ASB, Cho YK, Lee TH, Min YW, Park CH, Kwon JG, Park MI, Jung K, Park JK, Jung KW, Lim HC, Jung DH, Kim DH, Lim CH, Moon HS, Park JH, Choi SC, Suzuki H, Patcharatrakul T, Wu JCY, Lee KJ, Tanaka S, Siah KTH, Park KS, Kim SE, The Korean Society of Neurogastroenterology and Motility

  • KMID: 2500676
  • J Neurogastroenterol Motil.
  • 2020 Apr;26(2):180-203.
  • doi: 10.5056/jnm20014
Esophageal achalasia is a primary motility disorder characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis. Achalasia is a chronic disease that causes progressive irreversible loss of...
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Second Asian Consensus on Irritable Bowel Syndrome

Gwee KA, Gonlachanvit S, Ghoshal UC, Chua AS, Miwa H, Wu J, Bak YT, Lee OY, Lu CL, Park H, Chen M, Syam AF, Abraham P, Sollano J, Chang CS, Suzuki H, Fang X, Fukudo S, Choi MG, Hou X, Hongo M

  • KMID: 2454634
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):343-362.
  • doi: 10.5056/jnm19041
BACKGROUND/AIMS: There has been major progress in our understanding of the irritable bowel syndrome (IBS), and novel treatment classes have emerged. The Rome IV guidelines were published in 2016 and...
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Expression of Toll-like Receptors, Pro-, and Anti-inflammatory Cytokines in Relation to Gut Microbiota in Irritable Bowel Syndrome: The Evidence for Its Micro-organic Basis

Shukla R, Ghoshal U, Ranjan P, Ghoshal UC

  • KMID: 2422853
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):628-642.
  • doi: 10.5056/jnm18130
BACKGROUND/AIMS: A Subset of patients with irritable bowel syndrome (IBS) may have mild inflammation due to immune activation. Toll-like receptors (TLRs) and cytokines may cause intestinal inflammation. We studied their...
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Gut Microbiota-Brain Axis Modulation by a Healthier Microbiological Microenvironment : Facts and Fictions

Ghoshal UC

  • KMID: 2417267
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):4-6.
  • doi: 10.5056/jnm17150
No abstract available.
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Mapping of Brain Activations to Rectal Balloon Distension Stimuli in Male Patients with Irritable Bowel Syndrome Using Functional Magnetic Resonance Imaging

Guleria A, Karyampudi A, Singh R, Khetrapal , Verma A, Ghoshal UC, Kumar D

  • KMID: 2387833
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):415-427.
  • doi: 10.5056/jnm16148
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is associated with exaggerated cerebral response including emotional processing following visceral stimulation; though data on this issue is available in female IBS patients, it is...
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Pros and Cons While Looking Through an Asian Window on the Rome IV Criteria for Irritable Bowel Syndrome: Pros

Ghoshal UC

  • KMID: 2387823
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):334-340.
  • doi: 10.5056/jnm17020
A decade after Rome III, in 2016, Rome IV criteria were published. There are major differences between Rome IV and the earlier iteration, some of which are in line with...
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Esophageal Acidification During Nocturnal Acid-breakthrough with Ilaprazole Versus Omeprazole in Gastroesophageal Reflux Disease

Karyampudi A, Ghoshal UC, Singh R, Verma A, Misra A, Saraswat V

  • KMID: 2433521
  • J Neurogastroenterol Motil.
  • 2017 Apr;23(2):208-217.
  • doi: 10.5056/jnm16087
BACKGROUND/AIMS: Though nocturnal acid-breakthrough (NAB) is common in gastroesophageal reflux disease (GERD) patients, its clinical importance results from esophageal acidification, which has been shown to be uncommon. Ilaprazole, a long-acting...
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Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy

Ghoshal UC, Shukla R, Ghoshal U

The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely psychogenic in origin, is now understood to be multifactorial. One of the reasons for this paradigm shift is...
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Translation and Validation of Enhanced Asian Rome III Questionnaires in Bengali Language for Diagnosis of Functional Gastrointestinal Disorders

Rahman MM, Ghoshal UC, Rowshon AH, Ahmed F, Kibria MG, Hasan M, Gwee KA, Whitehead

  • KMID: 2203577
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):240-247.
  • doi: 10.5056/jnm15129
BACKGROUND/AIMS: Functional gastrointestinal disorders (FGIDs), diagnosed by symptom-based criteria due to lack of biomarkers, need translated-validated questionnaires in different languages. As Bengali, the mother tongue of Bangladesh and eastern India,...
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Irritable Bowel Syndrome, Particularly the Constipation-Predominant Form, Involves an Increase in Methanobrevibacter smithii, Which Is Associated with Higher Methane Production

Ghoshal U, Shukla R, Srivastava D, Ghoshal UC

BACKGROUND/AIMS: Because Methanobrevibacter smithii produces methane, delaying gut transit, we evaluated M. smithii loads in irritable bowel syndrome (IBS) patients and healthy controls (HC). METHODS: Quantitative real-time polymerase chain reaction for...
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Achalasia Is Associated With eNOS4a4a, iNOS22GA, and nNOS29TT Genotypes: A Case-control Study

Singh R, Ghoshal UC, Misra A, Mittal B

  • KMID: 2433477
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):380-389.
  • doi: 10.5056/jnm14123
BACKGROUND/AIMS: Achalasia is known to result from degeneration of inhibitory neurons, which are mostly nitrinergic. Characteristic features of achalasia include incomplete lower esophageal sphincter (LES) relaxation and esophageal aperistalsis. Nitric...
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Development, Translation and Validation of Enhanced Asian Rome III Questionnaires for Diagnosis of Functional Bowel Diseases in Major Asian Languages: A Rome Foundation-Asian Neurogastroenterology and Motility Association Working Team Report

Ghoshal UC, Gwee KA, Chen M, Gong XR, Pratap N, Hou X, Syam AF, Abdullah M, Bak YT, Choi MG, Gonlachanvit S, Chua AS, Chong KM, Siah KT, Lu CL, Xiong L, Whitehead

  • KMID: 2381235
  • J Neurogastroenterol Motil.
  • 2015 Jan;21(1):83-92.
  • doi: 10.5056/jnm14045
BAome III criteria. METHODS: After EAR3Q was developed by Asian experts by cCKGROUND/AIMS: The development-processes by regional socio-cultural adaptation of an Enhanced Asian Rome III questionnaire (EAR3Q), a cultural adaptation of...
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Pathogenesis of Irritable Bowel Syndrome: Is It Really in the Gene?

Ghoshal UC, Singh R

  • KMID: 2381187
  • J Neurogastroenterol Motil.
  • 2014 Jul;20(3):284-286.
No abstract available.
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Fecal Evacuation Disorder Among Patients With Solitary Rectal Ulcer Syndrome: A Case-control Study

Sharma A, Misra A, Ghoshal UC

  • KMID: 2381218
  • J Neurogastroenterol Motil.
  • 2014 Oct;20(4):531-538.
  • doi: 10.5056/jnm14030
BACKGROUND/AIMS: Data on frequency of fecal evacuation disorder (FED) among patients with solitary rectal ulcer syndrome (SRUS), hitherto an enigmatic condition, are scanty. Moreover, most such studies had limitations due...
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Defecation Frequency and Stool Form in a Coastal Eastern Indian Population

Panigrahi , Kar SK, Singh SP, Ghoshal UC

  • KMID: 2326238
  • J Neurogastroenterol Motil.
  • 2013 Jul;19(3):374-380.
BACKGROUND/AIMS: Data on normal stool form and frequency, which are important for defining constipation, are scanty; hence, we studied these in an eastern Indian population. METHODS: One thousand and two hundred...
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How to Perform and Interpret Timed Barium Esophagogram

Neyaz Z, Gupta M, Ghoshal UC

  • KMID: 2325798
  • J Neurogastroenterol Motil.
  • 2013 Apr;19(2):251-256.
Timed barium esophagogram (TBE) is a simple and objective method for assessing the esophageal emptying. The technique of TBE is similar to usual barium swallow with some modifications, which include...
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Primary Care Management of Chronic Constipation in Asia: The ANMA Chronic Constipation Tool

Gwee KA, Ghoshal UC, Gonlachanvit S, Chua AS, Myung SJ, Rajindrajith S, Patcharatrakul T, Choi MG, Wu JC, Chen MH, Gong XR, Lu CL, Chen CL, Pratap N, Abraham P, Hou XH, Ke M, Ricaforte-Campos JD, Syam AF, Abdullah M

  • KMID: 2325787
  • J Neurogastroenterol Motil.
  • 2013 Apr;19(2):149-160.
Chronic constipation (CC) may impact on quality of life. There is substantial patient dissatisfaction; possible reasons are failure to recognize underlying constipation, inappropriate dietary advice and inadequate treatment. The aim...
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Successful Outcome of Refractory Chronic Constipation by Surgical Treatment: A Series of 34 Patients

Kumar A, Lokesh HM, Ghoshal UC

  • KMID: 2325975
  • J Neurogastroenterol Motil.
  • 2013 Jan;19(1):78-84.
BACKGROUND/AIMS: Chronic constipation is commonly managed medically, and surgical options have been advocated in patients with refractory symptoms. We aimed to study the role of surgical procedures in patients with...
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