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Pharmacologic therapy for nonalcoholic steatohepatitis focusing on pathophysiology

Yoon IC, Eun JR

The paradigm of chronic liver diseases has been shifting. Although hepatitis B and C viral infections are still the main causes of liver cirrhosis and hepatocellular carcinoma (HCC), the introduction...
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Hepatic Arterial Infusion Chemotherapy Using the Port System in Advanced Gallbladder Cancer

Eun JR, Kim JW, Choi JH

Gallbladder (GB) cancer is relatively rare and has a poor prognosis, with a median survival time of less than 3 months. It is resistant to chemotherapy. Therefore, the role of...
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Massive bleeding from a rectal Dieulafoy lesion in a patient with alcoholic cirrhosis

Choi YH, Eun JR, Han JH, Lim H, Shin JA, Lee GH, Lee SH

Although Dieulafoy lesion can occur in any part of the gastrointestinal tract, its occurrence in the rectum is rare. Rectal Dieulafoy lesions have been associated with advanced age, renal failure,...
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Cellular origin of liver cancer stem cells

Eun JR

Over several decades, a hierarchical cancer stem cell (CSC) model has been established in development of solid cancers, including hepatocellular carcinoma(HCC). In terms of this concept, HCCs originate from liver...
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Cilostazol Decreases Ethanol-Mediated TNFalpha Expression in RAW264.7 Murine Macrophage and in Liver from Binge Drinking Mice

Lee YJ, Eun JR

Alcoholic hepatitis is a leading cause of liver failure in which the increased production of tumor necrosis factor alpha (TNFalpha) plays a critical role in progression of alcoholic liver disease....
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A study of the awareness of chronic liver diseases among Korean adults

Jun DW, Cho YK, Sohn JH, Lee CH, Kim SH, Eun JR

BACKGROUND/AIMS: Chronic liver disease is closely associated with lifestyle, and public enlightenment of the lifestyle factors is important in reducing prevalence of chronic liver disease. The KASL (Korean Association for...
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Pathological Complete Remission of Advanced Hepatocellular Carcinoma with Main Portal Vein Tumor Thrombosis by Hepatic Arterial Infusion Chemotherapy

Kim YG, Eun JR, Kim TN, Lee HJ, Kim JW, Chang JC, Yun SS, Choi JH

  • KMID: 2284198
  • Gut Liver.
  • 2010 Jun;4(2):266-269.
Cures for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) are rare and difficult. We report a case of pathologically confirmed complete remission of HCC induced by hepatic...
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Spontaneous submucosal dissection of the entire esophagus in a healthy man

Kim DH, Jang BI, Moon HJ, Oh HJ, Kim YK, Eun JR, Kim TN

  • KMID: 2258578
  • Korean J Med.
  • 2009 Aug;77(2):223-226.
Esophageal submucosal dissection can be caused by foreign bodies and endoscopic procedures. It rarely develops spontaneously. If a submucosal hematoma and false lumen are observed at esophagogastroduodenoscopy, the lesion will...
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Long-term clevudine therapy in nucleos(t)ide-naive and lamivudine-experienced patients with hepatitis B virus-related chronic liver diseases

Lee HJ, Eun JR, Lee CH, Hwang JS, Suh JI, Kim BS, Jang BK

BACKGROUNDS/AIMS: Clevudine is an effective antiviral nucleoside analogue, but there are few data regarding its long-term effects, resistance, and safety. The aim of this study was to evaluate the long-term...
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A case of cytomegalovirus esophagitis associated with upper gastrointestinal bleeding

Lee KH, Jang BI, Kim KO, Lee SH, Lee JY, Eun JR, Kim TN

  • KMID: 2081652
  • Korean J Med.
  • 2009 Apr;76(Suppl 1):S40-S43.
Cytomegalovirus (CMV) infections are common in immunocompromised patients, although they may occur occasionally in immunocompetent patients. The majority of CMV infections in immunocompetent adults are asymptomatic or associated with mild...
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A case of submucosal gastric lymphoepithelioma-like carcinoma

Lee SH, Jang BI, Eun JR, Kim KO, Lee KH, Kim TN

  • KMID: 2081651
  • Korean J Med.
  • 2009 Apr;76(Suppl 1):S35-S39.
Gastric lymphoepithelioma-like carcinoma (LELC) is a rare disease with a good prognosis. Submucosal LELC is very rare and difficult to diagnose by endoscopic biopsy. Endoscopic ultrasonography is the best modality...
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Two cases of gallbladder cancer diagnosed by detection of hemobilia

Kim KO, Jang BI, Eun JR, Lee KH, Lee SH, Kim TN

  • KMID: 1490331
  • Korean J Med.
  • 2009 Mar;76(3):352-357.
Hemobilia is a hemorrhage into the biliary tract and is a relatively rare cause of bleeding in the digestive tract. Gallbladder cancer is the most common tumor in the biliary...
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A Case of Peritoneal Seeding from a Ruptured Hepatocellular Carcinoma with Direct Invasion into the Stomach Causing Gastrointestinal Hemorrhage

Kim DH, Eun JR, Moon HJ, Oh HJ, Kim YK, Jang BI, Kim TN, Lee HJ

  • KMID: 783150
  • Korean J Gastroenterol.
  • 2009 Mar;53(3):194-197.
Hepatocellular carcinoma (HCC) rarely invades the gastrointestinal (GI) tract. It occurs in 0.7% to 2% of clinical HCC cases. Moreover, gastric invasion with GI hemorrhage via peritoneal seeding is very...
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Clinical Characteristics of Intrahepatic Cholangiocarcinoma and Prognostic Factors in Patients Who Received Non-surgical Treatment

Eun JR, Jang BI, Lee JY, Kim KO, Lee SH, Kim TN, Lee HJ

BACKGROUND/AIMS: This study was conducted to analyze the prognostic factors in patients with intrahepatic cholangiocarcinoma (ICC) who did not receive surgery. METHODS: Between August 1997 and November 2007, the medical...
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A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus

Lee HJ, Choi JW, Kim TN, Eun JR

Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus (HBV) replication but exhibits nephrotoxicity with severe hypophosphatemia when administered at a high dosage. This is the first report of severe hypophosphatemic...
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The Short Term Efficacy of Entecavir Therapy in Chronic Hepatitis B

Kim H, Chae HB, Jeon WJ, Park SM, Youn SJ, Eun JR, Lee HJ

  • KMID: 2320114
  • Yeungnam Univ J Med.
  • 2008 Jun;25(1):31-40.
BACKGROUND/AIMS: Entecavir is a synthetic nucleoside analogue, cyclopentyl guanine nucleoside, which has a potent antiviral effect and the least viral breakthrough in hepatitis B virus (HBV) replication. Entecavir has been...
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An adult case of glycogen storage disease type IIIa

Kim KO, Lee HJ, Choi JW, Eun JR, Choi JH

Glycogen storage disease type III (GSD III) is a very rare disorder caused by a deficiency in the activities of glycogen debranching enzymes (amylo-1-6-glucosidase and 4-alpha-glucanotransferase). GSD III is characterized...
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The usefulness of transient elastography (Fibroscan(R)) for predicting esophageal varices and esophageal variceal hemorrhage in patients with chronic liver diseases

Lee SH, Eun JR, Lee HJ, Kim TN, Jang BI, Choi JW, Park YS, Kim KO, Lee GH, Moon HJ, Lee SH

  • KMID: 2305843
  • Korean J Med.
  • 2008 May;74(5):491-499.
BACKGROUND/AIMS: This study was conducted to evaluate the efficacy of transient elastography (Fibroscan(R)) for predicting esophageal varices and esophageal variceal hemorrhage in patients with chronic liver diseases. METHODS: We studied 245...
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Clinical Overview of Acute Lower Gastrointestinal Bleeding

Kim KO, Jang BI, Kim TN, Eun JR, Lee KH, Lee SH, Choi JW, Park YS

  • KMID: 1477966
  • Korean J Gastrointest Endosc.
  • 2008 May;36(5):262-267.
BACKGROUND/AIMS: Acute lower gastrointestinal bleeding (LGIB) is a common disorder that requires hospitalization. Colonoscopy is considered as the procedure of choice for diagnosing acute LGIB. The aim of this study...
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Comparison of therapeutic results between combination therapy of peginterferon alpha-2a plus ribavirin and interferon alpha-2b plus ribavirin according to treatment duration in patients with chronic hepatitis C

Lee HJ, Eun JR, Choi JW, Kim KO, Moon HJ

BACKGROUND/AIMS: This study compared the efficacy and safety of combined peginterferon alfa (PEG-IFN) and ribavirin with that of combined interferon alpha (IFN-alpha) and ribavirin, according to the treatment duration...
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