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Long-Term Expansion of Functional Human Pluripotent Stem Cell-Derived Hepatic Organoids

Mun SJ, Hong YH, Ahn HS, Ryu JS, Chung KS, Son MJ

A human cell-based liver model capable of long-term expansion and mature hepatic function is a fundamental requirement for pre-clinical drug development. We previously established self-renewing and functionally mature human pluripotent...
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Predictors and outcomes of sepsis-induced cardiomyopathy in critically ill patients

Song MJ, Lee SH, Leem AY, Kim SY, Chung KS, Kim EY, Jung JY, Kang YA, Kim YS, Chang J, Park MS

Background: Sepsis-induced cardiomyopathy (SIC) occurs frequently in critically ill patients, but the clinical features and prognostic impact of SIC on sepsis outcome remain controversial. Here, we investigated the predictors and...
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The role of bilirubin to albumin ratio as a predictor for mortality in critically ill patients without existing liver or biliary tract disease

Choi JS, Chung KS, Lee EH, Lee SH, Lee SH, Kim SY, Jung JY, Kang YA, Park MS, Kim YS, Chang J, Leem AY

Background: Hyperbilirubinemia and hypoalbuminemia are frequently appeared and associated with poor prognosis in critically ill patients. We aim to evaluate the association between the bilirubin to albumin ratio and prognosis...
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Characteristics and Treatment Outcomes of Isoniazid Mono-Resistant Tuberculosis: A Retrospective Study

Kwak SH, Choi JS, Lee EH, Lee SH, Leem AY, Lee SH, Kim SY, Chung KS, Kim EY, Jung JY, Park MS, Kim YS, Chang J, Kang YA

Purpose: Isoniazid (INH) mono-resistant tuberculosis (Hr-TB) is a highly prevalent type of drug-resistant TB, possibly associated with unfavorable treatment outcomes. However, definitive guidelines on an optimal treatment regimen and duration...
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Risk Factors for Predicting Hypoxia in Adult Patients Undergoing Bronchoscopy under Sedation

Choi JS, Lee EH, Lee SH, Leem AY, Chung KS, Kim SY, Jung JY, Kang YA, Park MS, Chang J, Kim YS

Background: Flexible bronchoscopy is one of the essential procedures for the diagnosis and treatment of pulmonary diseases. The purpose of this study was to identify the risk factors associated with...
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National Trends of Meniscectomy and Meniscus Repair in Korea

Chung KS, Ha JK, Kim YS, Kim JH, Ra HJ, Kong DH, Wang PW, Choi CH, Kim JG

BACKGROUND: Meniscus surgeries are frequently performed in orthopaedics. However, their current status is not well known in many countries, including Korea. This study aimed to investigate the national trends of...
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The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1

Lee SH, Shin JH, Shin MH, Kim YS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, Park MS

BACKGROUND: Transforming growth factor β (TGF-β), retinoic acid (RA), p38 mitogen-activated protein kinase (MAPK), and MEK signaling play critical roles in cell differentiation, proliferation, and apoptosis. We investigated the effect...
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Rivaroxaban and Acetylsalicylic Acid for Prevention of Venous Thromboembolism Following Total Knee Arthroplasty in Korean Patients

Chung KS, Shin TY, Park SH, Kim H, Choi CH

PURPOSE: To investigate the incidence of venous thromboembolism (VTE) after total knee arthroplasty (TKA) with chemoprophylaxis using acetylsalicylic acid (AA) or rivaroxaban in Korean patients. MATERIALS AND METHODS: Between May 2011...
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Corrigendum to: Effects of salmon DNA fraction in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model

Ra HJ, Oh MY, Kim HJ, Lee SY, Eom DW, Lee SK, Kim SN, Chung KS, Jang HJ

The authors note that on pages 167 (Fig. 2A), 168 (Fig. 3A), and 169 (Fig. 4A), the figure label “RPF-001” should instead appear as “PRF-001.”
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Effects of salmon DNA fraction in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model

Ra HJ, Oh MY, Kim HJ, Lee SY, Eom DW, Lee SK, Kim SN, Chung KS, Jang HJ

PRF001 is a fragmented DNA polymer extracted from the testes of salmon. The purpose of this study was to assess the anti-inflammatory effect of PRF001 in vitro as well as...
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Factors Associated with Lung Function Recovery at the First Year after Lung Transplantation

Yoon BR, Park JE, Kim CY, Park MS, Kim YS, Chung KS, Song JH, Paik HC, Lee JG, Kim SY

PURPOSE: Post-operative pulmonary function is an important prognostic factor for lung transplantation. The purpose of this study was to identify factors affecting recovery of forced expiratory volume in 1 second...
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Comparison of self-reported and accelerometer-assessed measurements of physical activity according to socio-demographic characteristics in Korean adults

Lee SW, Shim JS, Song BM, Lee HJ, Bae HY, Park JH, Choi HR, Yang JW, Heo JE, Cho SM, Lee GB, Hidalgo DH, Kim TH, Chung KS, Kim HC

OBJECTIVES: Previous studies have shown relatively low correlations between self-reported and accelerometer-assessed physical activity (PA). However, this association differs by socio-demographic factors, and this relationship has not been fully investigated...
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Comparison of Poly-L-Lactic Acid and Poly-L-Lactic Acid/Hydroxyapatite Bioabsorbable Screws for Tibial Fixation in ACL Reconstruction: Clinical and Magnetic Resonance Imaging Results

Lee DW, Lee JW, Kim SB, Park JH, Chung KS, Ha JK, Kim JG, Kim WJ

BACKGROUND: The purpose of this study was to compare the clinical and radiological results of 2 different tibial fixations performed using bioabsorbable screws with added hydroxyapatite (HA) and pure poly-L-lactic...
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Upregulation of mitochondrial NAD⁺ levels impairs the clonogenicity of SSEA1⁺ glioblastoma tumor-initiating cells

Son MJ, Ryu JS, Kim JY, Kwon Y, Chung KS, Mun SJ, Cho YS

Emerging evidence has emphasized the importance of cancer therapies targeting an abnormal metabolic state of tumor-initiating cells (TICs) in which they retain stem cell-like phenotypes and nicotinamide adenine dinucleotide (NAD⁺)...
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Value of Serum Cystatin C Measurement in the Diagnosis of Sepsis-Induced Kidney Injury and Prediction of Renal Function Recovery

Leem AY, Park MS, Park BH, Jung WJ, Chung KS, Kim SY, Kim EY, Jung JY, Kang YA, Kim YS, Kim SK, Chang J, Song JH

PURPOSE: Acute kidney injury (AKI) is common in critically ill patients. Serum cystatin C has emerged as a reliable marker of AKI. We sought to assess the value of serum...
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Implications of Plasma Renin Activity and Plasma Aldosterone Concentration in Critically Ill Patients with Septic Shock

Chung KS, Song JH, Jung WJ, Kim YS, Kim SK, Chang J, Park MS

BACKGROUND: The renin-angiotensin-aldosterone system is closely associated with volume status and vascular tone in septic shock. The present study aimed to assess whether plasma renin activity (PRA) and plasma aldosterone...
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A Pilot Study of the Effectiveness of Medical Emergency System Implementation at a Single Center in Korea

Lee SH, Leem AY, Nho Y, Kim YA, Kim KD, Kim YS, Kim SK, Chung KS

BACKGROUND: An automatic alarm system was developed was developed for unexpected vital sign instability in admitted patients to reduce staffing needs and costs related to rapid response teams. This was...
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Lethal Hyperammonemia due to Ornithine Transcarbamylase Deficiency in a Patient with Severe Septic Shock

Hwang JA, Song JH, Lee YS, Chung KS, Kim SY, Kim EY, Jung JY, Kang YA, Kim YS, Chang J, Park MS

Severe hyperammonemia can occur as a result of inherited or acquired liver enzyme defects in the urea cycle, among which ornithine transcarbamylase deficiency (OTCD) is the most common form. We...
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Clinical Practice Guideline of Acute Respiratory Distress Syndrome

Cho YJ, Moon JY, Shin ES, Kim JH, Jung H, Park SY, Kim HC, Sim YS, Rhee CK, Lim J, Lee SJ, Lee WY, Lee HJ, Kwak SH, Kang EK, Chung KS, Choi WI, The Korean Society of Critical Care Medicine and the Korean Academy of Tuberculosis and Respiratory Diseases Consensus Group

There is no well-stated practical guideline for mechanically ventilated patients with or without acute respiratory distress syndrome (ARDS). We generate strong (1) and weak (2) grade of recommendations based on...
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Anatomy as Elective Course for Fourth-Year Medical Students

Kong TH, Kim SH, Son YH, Chung KS, Jin HK, Jang HW, Oh CS

Five medical students in the fourth-year took anatomy as their elective courses for 1 month. They dissected one cadaver, and investigated Digital Report, under the course subjects as follows; (1)...
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