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Motilitone toxicity in a dog

Kim YH, Ahn JO, Jeong Y, Kang MS, Choi JH, Chung JY

A three-month-old, intact male Maltese dog was presented to the hospital with lethargy after taking human medication, Motilitone. Physical examination, including a neurological examination, revealed no remarkable findings, but cholinergic...
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Pathobiolgy and Management of Alzheimer’s Disease

Kim H, Chung JY

Amyloid and tau protein abnormalities have been identified as the main causes of Alzheimer’s disease but exact mechanisms remain to be revealed. Especially, amyloid beta and tau protein coupling and...
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Nationwide “Pediatric Nutrition Day” survey on the nutritional status of hospitalized children in South Korea

Lee YM, Ryoo E, Hong J, Kang B, Choe BH, Seo JH, Park JS, Jang HJ, Lee Y, Chang EJ, Chang JY, Lee HJ, Kim JY, Lee EH, Kim HJ, Chung JY, Choi YJ, Choi SY, Kim SC, Kang KS, Yi DY, Moon KR, Lee JH, Kim YJ, Yang HR

BACKGROUND/OBJECTIVES: To evaluate the nutritional status and prevalence of malnutrition in hospitalized children at admission and during hospitalization in South Korea. SUBJECTS/METHODS: This first cross-sectional nationwide “Pediatric Nutrition Day (pNday)” survey...
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Molecular Detection and Epidemiology of Etiologic Agents among Children with Acute Gastroenteritis at a Secondary Hospital from 2015 to 2018

Kim YS, Chung JY

Purpose: The multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) test developed recently can help detect enteric pathogens of acute gastroenteritis (AGE). This study aimed to investigate the epidemiology of pathogens in...
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Comparison of the presentation of atopic dermatitis induced by trinitrochlorobenzene and house dust mite in NC/Nga mice

Kim YH, Kim TH, Kang MS, Ahn JO, Choi JH, Chung JY

Background: Atopic dermatitis (AD) is a common chronic inflammatory skin disease. To understand AD, there have been many trials establishing AD animal models. Although various trials to establish AD animal...
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Development and validation of a method for the simultaneous quantification of endogenous steroids metabolized by CYP3A

Lee Y, Chae W, Yoon S, Chung JY, Cho JY

Cytochrome P450 (CYP) 3A enzymes, the most important phase 1 drug-metabolizing enzymes, are responsible for 50% of the metabolism of clinically used drugs. CYP3A activity varies widely among individuals, which...
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Dexmedetomidine Improves Locomotor Function and Alleviates Thermal Hyperalgesia Following Sciatic Nerve Crush Injury in Rats

Jang MS, Han JH, Kim DO, Woo G, Kwon JI, Chung JY, Lee BJ, Yi JW

Purpose: The effects of dexmedetomidine on locomotor function and thermal hyperalgesia in sciatic nerve crush injury (SNCI) were investigated using rats. Methods: After exposing the right sciatic nerve, the sciatic nerve...
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Methodological Study on the Evaluation of Face Mask Use Scale among Public Adult: Cross-Language and Psychometric Testing

Lam SC, Chong AC, Chung JY, Lam MY, Chan LM, Shum CY, Wong EY, Mok YM, Lam MT, Chan MM, Tong KY, Chu OL, Siu FK, Cheung JH

PURPOSE: This study aimed to establish the translation adequacy and examine the psychometric properties of Face Mask Use Scale (FMUS). METHODS: This methodological study employed a cross-sectional design with repeated measures....
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Polydeoxyribonucleotide Ameliorates Inflammation and Apoptosis in Achilles Tendon-Injury Rats

Rho JH, Ko IG, Jin JJ, Hwang L, Kim SH, Chung JY, Hwang TJ, Han JH

Purpose: Adenosine A2A receptor agonist polydeoxyribonucleotide (PDRN) possesses an anti-inflammatory effect and suppress apoptotic cell death in several disorders. In this current study, the effect of PDRN on inflammation and...
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Fruit and vegetable consumption frequency and mental health in Korean adolescents: based on the 2014–2017 Korea Youth Risk Behavior Survey

Oh Jw, Chung Jy

Purpose: This study examined the association between fruit and vegetable intake and mental health in Korean adolescents. Methods: This study used the data from the 2014–2017 Korea Youth Risk Behavior Survey,...
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Development of a physiologically-based pharmacokinetic model for cyclosporine in Asian children with renal impairment

Yoon S, Yi S, Rhee SJ, Lee HA, Kim Y, Yu KS, Chung JY

This study aimed to assess the pharmacokinetics of cyclosporine A (CsA) in Asian children with renal impairment (RI) by developing a physiologically-based pharmacokinetic (PBPK) model with Simcyp Simulator. The PBPK...
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Management of Acute Gastroenteritis in Children: A Survey among Members of the Korean Society of Pediatric Gastroenterology, Hepatology, and Nutrition

Seo JH, Shim JO, Choe BH, Moon JS, Kang KS, Chung JY

PURPOSE: No national survey has yet described the guidelines followed by Korean pediatricians to treat acute gastroenteritis (AGE). An online survey was performed to investigate the management of AGE followed...
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Nationwide Survey for Application of ROME IV Criteria and Clinical Practice for Functional Constipation in Children

Jang HJ, Chung JY, Seo JH, Moon JS, Choe BH, Shim JO

BACKGROUND: This study aimed to investigate the awareness and application of ROME IV criteria for functional constipation (FC) in real-world practices and assessed differences between pediatric gastroenterologists (PGs) and general...
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Exercise Participation Experiences of Colorectal Cancer Survivors

Byeon JY, Lee MK, Chung JY, Yoo S, Jeon JY

PURPOSE: The purpose of this study was to investigate the exercise participation experiences of colorectal cancer survivors. METHODS: A phenomenological method was used in this study. Ten adult colorectal cancer survivors...
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Digital therapeutics and clinical pharmacology

Chung JY

Digital therapeutics (DTx) is a new subsection of digital health that is primarily driven by software and will be of great interest to clinical pharmacologists. In this article, an overview...
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Prenatal Exposure to Lead and Chromium is Associated with IL-13 Levels in Umbilical Cord Blood and Severity of Atopic Dermatitis: COCOA Study

Kim J, Kim S, Woo SY, Chung JY, Hong YS, Oh SY, Choi SJ, Oh SY, Kim KW, Shin YH, Won HS, Lee KJ, Kim SH, Kwon JY, Lee SH, Hong SJ, Ahn K

There have been few studies investigating the association between atopic dermatitis (AD) and prenatal exposure to heavy metals. We aimed to evaluate whether prenatal exposure to heavy metals is associated...
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Effect of Polydeoxyribonucleotide on Lipopolysaccharide and Sevoflurane-Induced Postoperative Cognitive dysfunction in Human Neuronal SH-SY5Y Cells

Jeong H, Chung JY, Ko IG, Kim SH, Jin JJ, Hwang L, Moon EJ, Lee BJ, Yi JW

PURPOSE: Postoperative cognitive dysfunction (POCD) is a complication of surgery characterized by acute cognitive dysfunction, memory impairment, and loss of attention. The effect of polydeoxyribonucleotide (PDRN) on the POCD environment...
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Postmenopausal Burning Mouth Syndrome Relieved by Clonazepam

Chung JY, Choi PK, Kang HG

Burning mouth syndrome (BMS) is an intraoral chronic pain disorder characterized by continuous burning sensations. BMS occurs particularly in postmenopausal women, and its etiology is not definite and considered idiopathic....
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Toxoplasma Encephalitis in a Patient with Human Immunodeficiency Virus Infection

Choi PK, Chung JY, Kang HG

Toxoplasma encephalitis is an opportunistic infection that may occur in immunocompromised or advanced HIV (Human Immunodeficiency Virus) patients and lead to serious complications in the CNS. We report a 44-year-old...
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Correlation of respiratory syncytial virus infection with climate parameters and air pollution levels in Korean children during 2005–2012

Jung JH, Chu SY, Kim JY, Han TH, Park SH, Chung JY, Kim HB

PURPOSE: Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infection (LRTI) in infants and children. We investigated the association of meteorological conditions and air pollution...
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