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Epidemiology of C5 Palsy after Cervical Spine Surgery: a 21-Center Study

Oh JK, Hong JT, Kang DH, Kim SW, Kim SW, Kim YJ, Chung CK, Shin JJ, Yi S, Lee JK, Lee JH, Lee CH, Lee HJ, Chun HJ, Cho DC, Cho YE, Jin YJ, Choi KC, Han IH, Hyun SJ, Hur JW, Kim KJ

OBJECTIVE: C5 palsy is a severe complication after cervical spine surgery, the pathophysiology of which remains unclear. This multicenter study investigated the incidence of C5 palsy following cervical spine surgery...
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In-Hospital and Post-Discharge Recovery after Acute Ischemic Stroke: a Nationwide Multicenter Stroke Registry-base Study

Jang MU, Kang J, Kim BJ, Hong JH, Yeo MJ, Han MK, Lee BC, Yu KH, Oh MS, Choi KC, Lee SH, Hong KS, Cho YJ, Park JM, Cha JK, Kim DH, Park TH, Lee KB, Lee SJ, Lee J, Kim JT, Kim DE, Choi JC, Lee J, Lee JS, Gorelick P, Bae HJ

BACKGROUND: Using data from a large national stroke registry, we aimed to investigate the incidence and determinants of in-hospital and post-discharge recovery after acute ischemic stroke and the independence of...
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Measuring the quality of life of the families of children with eczema in Hong Kong

Cheng NS, Chau PC, Hon KL, Choi KC, Kung JS, Ng WG, Leung TF

BACKGROUND: Eczema is the most common skin problem among children in Hong Kong. Previous studies have highlighted that the quality of life of the families of children with eczema influences...
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A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models

Heo JR, Hwang KA, Kim SU, Choi KC

PURPOSE: In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A hNSC line (HB1.F3) was transduced into...
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Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation

Ayala-Cuellar AP, Kang JH, Jeung EB, Choi KC

Mesenchymal stem cells are classified as multipotent stem cells, due to their capability to transdifferentiate into various lineages that develop from mesoderm. Their popular appeal as cell-based therapy was initially...
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Treatment with Phytoestrogens Reversed Triclosan and Bisphenol A-Induced Anti-Apoptosis in Breast Cancer Cells

Lee GA, Choi KC, Hwang KA

Triclosan (TCS) and bisphenol A (BPA) are endocrine-disrupting chemicals that interfere with the hormone or endocrine system and may cause cancer. Kaempferol (Kaem) and 3,3′-diindolylmethane (DIM) are phytoestrogens that play...
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Association between Smoking and Unintentional Injuries among Korean Adults

Choi KC, Kim SA, Kim NR, Shin MH

Using a cross-sectional representative national survey, we evaluated the relationship between cigarette smoking and unintentional injuries among Korean adults. We used data from the 2009 Korean Community Health Survey. Smoking...
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Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse

Lee MY, Kang JS, Go RE, Byun YS, Wi YJ, Hwang KA, Choi JH, Kim HC, Choi KC, Nam KH

Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha (TNF-α)...
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The Brain Donation Program in South Korea

Kim Y, Suh YL, Kim SJ, Bae MH, Kim JB, Kim Y, Choi KC, Huh GY, Kim EJ, Lee JS, Kang HW, Shim SM, Lim HJ, Koh YH, Kim BC, Lee KH, Lee MC, Lee HW, Lim TS, Seeley WW, Kim HJ, Na DL, Lee KH, Seo SW

PURPOSE: Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia...
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Pathological Significance of Tissue Trapped in Retrieved OptEase Vena Cava Filter at 18th Day after Installation in Patient with Deep Vein Thrombosis

Park SM, Son JW, Hong KS, Choi KC

The retrievable type of inferior vena cava filter has been widely used to prevent pulmonary thromboembolism in patients with deep vein thrombosis and contraindication of anticoagulation. Physicians make considerable efforts...
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Early Detection of Hidden Adenocarcinoma through the Prompt Pericardiocentesis in Patient with Small Pericardial Effusion

Shinebayar B, Gill SY, Jeong H, Choi KC, Hong J, Park SM

Pericardial drainage is an important diagnostic and therapeutic option in the symptomatic patient with large amount of pericardial effusion (PE). However, when the amount of PE is relatively small, physicians...
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Anti-proliferative Effect of Engineered Neural Stem Cells Expressing Cytosine Deaminase and Interferon-β against Lymph Node–Derived Metastatic Colorectal Adenocarcinoma in Cellular and Xenograft Mouse Models

Park GT, Kim SU, Choi KC

PURPOSE: Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, genetically engineered human neural stem cells...
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Effects of Percutaneous Sacroplasty on Pain and Mobility in Sacral Insufficiency Fracture

Choi KC, Shin SH, Lee DC, Shim HK, Park CK

OBJECTIVE: Sacral insufficiency fracture (SIF) contributes to severe low back pain. Prolonged immobilization resulting from SIF can cause significant complications in the elderly. Sacroplasty, a treatment similar to vertebroplasty, has...
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Clinical Evaluation of Rapid Diagnostic Test Kit for Scrub Typhus with Improved Performance

Kim YJ, Park S, Premaratna R, Selvaraj S, Park SJ, Kim S, Kim D, Kim MS, Shin DH, Choi KC, Kwon SH, Seo W, Lee NT, Kim SH, Kang HK, Kim YW

Diagnosis of scrub typhus is challenging due to its more than twenty serotypes and the similar clinical symptoms with other acute febrile illnesses including leptospirosis, murine typhus and hemorrhagic fever...
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iRhoms; Its Functions and Essential Roles

Lee MY, Nam KH, Choi KC

In Drosophila, rhomboid proteases are active cardinal regulators of epidermal growth factor receptor (EGFR) signaling pathway. iRhom1 and iRhom2, which are inactive homologs of rhomboid intramembrane serine proteases, are lacking...
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Real-Time Quaking-Induced Conversion Analysis for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Korea

Park JH, Choi YG, Lee YJ, Park SJ, Choi HS, Choi KC, Choi EK, Kim YS

BACKGROUND AND PURPOSE: The level of 14-3-3 protein in the cerebrospinal fluid (CSF) is increased in Creutzfeldt-Jakob disease (CJD) patients, which has led to it being used as a clinical...
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Analysis of Factors Related to the Prescription of Antibiotics for the Acute Upper Respiratory Infection

Choi WJ, Yim E, Kim TH, Suh HS, Choi KC, Chung W

BACKGROUND: Initial treatment of acute upper respiratory infection (AURI) should not include antibiotics because most AURIs are caused by virus. However, the prescription rate of antibiotics in Korea is higher...
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Role of the epithelial-mesenchymal transition and its effects on embryonic stem cells

Kim YS, Yi BR, Kim NH, Choi KC

The epithelial-mesenchymal transition (EMT) is important for embryonic development and the formation of various tissues or organs. However, EMT dysfunction in normal cells leads to diseases, such as cancer or...
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Effects of anti-obesity drugs, phentermine and mahuang, on the behavioral patterns in Sprague-Dawley rat model

Go RE, Hwang KA, Kim SH, Lee MY, Kim CW, Jeon SY, Kim YB, Choi KC

According to WHO global estimates from 2008, more than 1.4 billion adults were overweight and among them, over 200 million men and 300 million women were obese. Although the main...
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Surgical Correction and Osteosynthesis for Cranial Displaced Pelvic Nonunion: Technical Note and Two Cases Report Regarding Anterior Correction and Osteosynthesis Following Posterior Release

Choi KC, Ha JY, Kim WY

Nonunion of an unstable pelvic fracture with cranial displacement pelvic surgery is technically difficult due to a large amount of bleeding and the risk of nerve damage. In addition, surgical...
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