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Treatment of advanced stage cholangiocarcinoma: Systemic therapy may be the starting step for radical surgery

Baik H, Seo SH, Kim KH, Choi MY, Park YH, Choi CS

Cholangiocarcinoma is the most common biliary malignancy and the second most common hepatic malignancy following hepatocellular carcinoma. It can be classified anatomically as intrahepatic cholangiocarcinoma (iCCA), perihilar CCA, or distal...
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Sex Differences in Autism-Like Behavioral Phenotypes and Postsynaptic Receptors Expression in the Prefrontal Cortex of TERT Transgenic Mice

Kim KC, Cho KS, Yang SM, Gonzales E, Valencia S, Eun PH, Choi CS, Mabunga DF, Kim JW, Noh JK, Kim HJ, Jeon SJ, Han SH, Bahn GH, Shin CY

Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years. Aside from its various characteristics is the baffling male preponderance over the female...
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Clinicopathologic characteristics and prognosis of remnant gastric cancer

Kwon TG, Kim KH, Seo SH, Jeong IS, Park YH, An MS, Ha TK, Bae KB, Choi CS, Oh SH

PURPOSE: Remnant gastric cancer is defined as a malignant tumor developing on the remnant side of stomach after partial gastrectomy. The purpose of this study is to evaluate the clinical...
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Erratum: Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development

Kim KC, Choi CS, Gonzales E, Mabunga DF, Lee SH, Jeon SJ, Hwangbo R, Hong M, Ryu JH, Han SH, Bahn GH, Shin CY

In the ‘Acknowledgements’ section on page 263 of the original article, the grant number was incorrectly stated.
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Effect of Rifaximin on Hepatic Fibrosis in Bile Duct-ligated Rat Model

Shin SK, Kwon OS, Lee JJ, Park YH, Choi CS, Jeong SH, Choi DJ, Kim YS, Kim JH

BACKGROUND/AIMS: The translocation of bacteria and their lipopolysaccharides from the gut can promote fibrosis in cirrhotic patients. The aim of this study was to investigate the effects of rifaximin on...
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Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development

Kim KC, Choi CS, Gonzales E, Mabunga DF, Lee SH, Jeon SJ, Hwangbo R, Hong M, Ryu JH, Han SH, Bahn GH, Shin CY

The valproic acid (VPA)-induced animal model is one of the most widely utilized environmental risk factor models of autism. Autism spectrum disorder (ASD) remains an insurmountable challenge among neurodevelopmental disorders...
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Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders

Kim KC, Gonzales E, Lázaro MT, Choi CS, Bahn GH, Yoo HJ, Shin CY

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and communication impairments, as well as repetitive and restrictive behaviors. The phenotypic heterogeneity of ASD has made it overwhelmingly...
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Outcome of External Ventricular Drainage according to the Operating Place: the Intensive Care Unit versus Operating Room

Kim SO, Song WJ, Won YS, Yang JY, Choi CS

BACKGROUND: External ventricular drainage (EVD) is an important procedure for draining excessive cerebrospinal fluid (CSF) and monitoring intracranial pressure. Generally, EVD is performed in the operating room (OR) under aseptic...
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Cholangiocarcinoma in choledochal cyst after cystoenterostomy: how a mistreated choledochal cyst can progress to malignancy

Baik H, Park YH, Seo SH, An MS, Kim KH, Bae KB, Choi CS, Oh SH, Choi YK

This case report presents an unusual case of cholangiocarcinoma arising nearly 35 years after cystoduodenostomy for choledochal cyst. The patient visited our hospital with dyspepsia and studies revealed bezoar within...
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Effectiveness of Osteoporosis Drug in Postmenopausal Women with Spinal Compression Fracture: Combined Consecutive Therapy of Teriparatide and Raloxifene versus Bisphosphonate Single

Shin CJ, Kim S, Choi CS, Shin HC, Kwon YJ

OBJECTIVE: Bisphosphonate, a typical bone resorption inhibitor, is an important first-line drug for treating osteoporosis. Recent studies show a novel paradigm in stimulating bone formation. Teriparatide, which is composed of...
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The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance

Yoon MS, Choi CS

Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex...
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Effects of Triclosan on Neural Stem Cell Viability and Survival

Park BK, Gonzales E, Yang SM, Bang M, Choi CS, Shin CY

Triclosan is an antimicrobial or sanitizing agent used in personal care and household products such as toothpaste, soaps, mouthwashes and kitchen utensils. There are increasing evidence of the potentially harmful...
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Repeated Neonatal Propofol Administration Induces Sex-Dependent Long-Term Impairments on Spatial and Recognition Memory in Rats

Gonzales E, Yang SM, Choi CS, Mabunga DF, Kim HJ, Cheong JH, Ryu JH, Koo BN, Shin CY

Propofol is an anesthetic agent that gained wide use because of its fast induction of anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration and long-term impairment...
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Use of in vivo magnetic resonance spectroscopy for studying metabolic diseases

Hwang JH, Choi CS

Owing to the worldwide obesity epidemic and the sedentary lifestyle in industrialized countries, the number of people with metabolic diseases is explosively increasing. Magnetic resonance spectroscopy (MRS), which is fundamentally...
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Risk Factors of Chronic Subdural Hematoma Progression after Conservative Management of Cases with Initially Acute Subdural Hematoma

Lee JJ, Won Y, Yang T, Kim S, Choi CS, Yang J

OBJECTIVE: Acute subdural hematoma (ASDH) patients are treated conservatively or surgically according to the guidelines for surgical treatment. Many patients with thin ASDH and mild neurologic deficit are managed conservatively,...
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Effects of Atomoxetine on Hyper-Locomotive Activity of the Prenatally Valproate-Exposed Rat Offspring

Choi CS, Hong M, Kim KC, Kim JW, Yang SM, Seung H, Ko MJ, Choi DH, You JS, Shin CY, Bahn GH

A substantial proportion of patients with autism spectrum disorder (ASD) display hyperactivity as a comorbid symptom. Exposure to valproic acid (VPA) during pregnancy produces ASD-like core behavioral phenotypes as well...
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Relationship between 15-hydroxyprostaglandin dehydrogenase and gastric adenocarcinoma

Kang JH, Kang SH, Seo SH, Shin JH, An MS, Ha TK, Bae KB, Kim TH, Choi CS, Oh SH, Kang MS, Kim KH

PURPOSE: Prostaglandin E2 (PGE2) is a contributory carcinogen in gastric adenocarcinoma. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catabolizes PGE2 by oxidizing its 15(s)-hydroxy group. The aim of this study was to investigate the...
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Clinical Analysis of Risk Factors for Recurrence in Patients with Chronic Subdural Hematoma Undergoing Burr Hole Trephination

Jeong SI, Kim SO, Won YS, Kwon YJ, Choi CS

OBJECTIVE: Chronic subdural hematoma (CSDH) is one of the most common types of intra-cranial hemorrhages usually associated with trauma. Surgical treatment is the treatment of choice and burr hole trephination...
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Harmonic ultrasonography for the detection of microlithiasis in the gallbladder

Choi CS, Ku YJ, Yoon DY, Yun EJ, Seo YL, Lim KJ, Baek S, Bae SH, Nam ES

PURPOSE: To validate the use of harmonic ultrasonography (US) in the detection of gallbladder microlithiasis. METHODS: From November 30, 2012, to January 18, 2014, fundamental US (FUS) and harmonic US with...
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Gastrointestinal Tract Abnormalities Induced by Prenatal Valproic Acid Exposure in Rat Offspring

Kim JW, Choi CS, Kim KC, Park JH, Seung H, Joo SH, Yang SM, Shin CY, Park SH

  • KMID: 2317832
  • Toxicol Res.
  • 2013 Sep;29(3):173-179.
In-utero exposure to valproic acid (VPA) has been known as a potent inducer of autism spectrum disorder (ASD), not only in humans, but also in animals. In addition to the...
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