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Evaluation of in vitro and in vivo genotoxicity of Angelica acutiloba in a standard battery of assays

Yun JW, Kim YS, Kwon E, Kim SH, You JR, Kim HH, Che JH, Kang BC

Among three representative species of Angelica found in Asian countries, including Korea, China, and Japan, Angelica acutiloba (AA) has been used as traditional herbal medicine with antitumor, anti-inflammatory, anti-obesity, and...
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Preclinical safety assessment of Angelica acutiloba using a 13-week repeated dose oral toxicity study in rats

Yun JW, Kwon E, Kim SH, You JR, Kim YS, Park IA, Kim HH, Che JH, Kang BC

Angelica acutiloba (AA), a Japanese species of Danggui, has been used worldwide as a traditional herbal medicine with several bioactivities including anti-diabetic, anti-allergic, anti-inflammatory, anti-tumor, and anti-obesity. However, there is...
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Bone marrow stem/progenitor cell mobilization in C57BL/6J and BALB/c mice

Lee H, Che JH, Oh JE, Chung SS, Jung HS, Park KS

  • KMID: 2312115
  • Lab Anim Res.
  • 2014 Mar;30(1):14-20.
Bone marrow (BM) has been considered as a reservoir of stem/progenitor cells which are able to differentiate into ectodermal, endodermal, and mesodermal origins in vitro as well as in vivo....
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Granulocyte-Derived Cationic Peptide Enhances Homing and Engraftment of Bone Marrow Stem Cells after Transplantation

Lee H, Che JH, Lee JC, Chung SS, Jung HS, Park KS

Current strategies to accelerate hematopoietic reconstitution after transplantation include transplantation of greater numbers of hematopoietic stem/progenitor cells (HSPCs) or ex vivo expansion of harvested HSPCs before transplant. However, the number...
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Establishment of Efficacy and Safety Assessment of Human Adipose Tissue-Derived Mesenchymal Stem Cells (hATMSCs) in a Nude Rat Femoral Segmental Defect Model

Choi HJ, Kim JM, Kwon E, Che JH, Lee JI, Cho SR, Kang SK, Ra JC, Kang BC

Human adipose tissue-derived mesenchymal stem cell (hATMSC) have emerged as a potentially powerful tool for bone repair, but an appropriate evaluation system has not been established. The purpose of this...
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The Role of Endothelin Receptor A during Myelination of Developing Oligodendrocytes

Jung KJ, Kim DW, Lee HN, Lee YS, Lee SJ, Che JH, Lee YH, Kang BC

Endothelin (ET)-1 and its receptors (ETA and ETB receptor) are present in the central nervous system. ET exerts biological effects on gliogenesis and glial cell functions. In order to define...
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Platynosomum fastosum Infestation in a Domestic Cat in Korea

Kim JM, Che JH, Jeong DH, Kang BC

  • KMID: 2312082
  • Lab Anim Res.
  • 2010 Sep;26(3):307-309.
Cat liver fluke (Platynosomum fastosum) was identified upon necropsy of a Felis catus (domestic cat). This trematode has not been reported in domestic cats previously in Korea. Diagnosis of this...
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Safety Evaluation of Human Fibroblasts in Mice: Tumorigenicity, 13-week Toxicity and Distribution Studies

Choi HJ, Kwon E, Sohn JH, Che JH, Lee KH, Kim JW, Choi J, Kang BC

  • KMID: 2312064
  • Lab Anim Res.
  • 2010 Jun;26(2):181-196.
Human fibroblasts were developed for cellular therapy with the aim of correcting of depressed scars, but the safety of that in vivo is unclear. In this study, we assessed the...
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Radiographic Analysis of the Tibial Axis on the Antero-posterior and Lateral view of Knee

Chung JB, Han CD, Yang IW, Che JH

  • KMID: 2340694
  • J Korean Knee Soc.
  • 2005 Jun;17(1):58-63.
PURPOSE: The purpose of this study is to evaluate the use of plain knee films in assessing the position of tibial component after total knee arthroplasty. MATERIALS AND METHODS: Plain radiological...
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The Relationship between the Variation of the femoral neckshaft angle according to Age and the Fracture of the Hip

Jahng JS, Moon SH, Che JH

PURPOSE: Femur neck-shaft angles were obtained from plain radiographs of the pelvis and their changes according to age were assessed along with their correlations to hip fracture incidence. MATERIALS AND METHODS:...
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Unilateral versus Bilateral Pedide Scrwe Fixation in Lumbar Spinal Fusion

Suk KS, Lee HM, Kim NH, Ha JW, Che JH

  • KMID: 2189432
  • J Korean Orthop Assoc.
  • 1999 Oct;34(5):943-948.
OBJECTIVES: To determine if unilateral pedicle screw fixation is comparable to bilateral fixation in one-or two-segment lumbar spinal fusion. METHODS: Eighty-eight patients with spinal stenosis or spondylolisthesis were assigned to...
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