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Treatment Strategy for Impending Instability in Spinal Metastases

Kim YH, Kim J, Chang SY, Kim H, Chang BS

Background: Determining surgical management of a spinal metastasis is difficult owing to the involvement of multiple factors.The spinal instability neoplastic score (SINS) system is a reliable tool to evaluate instability...
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Morin Hydrate Inhibits Influenza Virus entry into Host Cells and Has Anti-inflammatory Effect in Influenzainfected Mice

Hong EH, Song aH, Kim SR, Cho J, Jeong B, Yang H, Jeong JH, Ahn JH, Jeong H, Kim SE, Chang SY, Ko HJ

Influenza virus is the major cause of seasonal and pandemic flu. Currently, oseltamivir, a potent and selective inhibitor of neuraminidase of influenza A and B viruses, is the drug of...
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Treatment Strategy for Metastatic Spinal Tumors: A Narrative Review

Chang SY, Mok S, Park SC, Kim H, Chang BS

Metastatic spinal tumors are common, and their rising incidence can be attributed to the expanding aging population and increased survival rates among cancer patients. The decision-making process in the treatment...
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Clinical Significance of Improved Intraoperative Neurophysiological Monitoring Signal during Spine Surgery: A Retrospective Study of a Single-Institution Prospective Cohort

Wi SM, Lee HJ, Kang T, Chang SY, Kim SM, Chang BS, Lee CK, Kim H

Study Design: Retrospective case series. Purpose: We reviewed the cases that showed significant improvement of intraoperative neurophysiological monitoring (IONM) signals during spine surgery to assess whether there is a correlation with...
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Reversible Psychosis Caused by Disconnection of the Limbic System: Clinical Reasoning Using Diffusion Tensor Tractography

Chang Sy, Kim Y

Injury to the limbic system can result in amnesia, language difficulties, behavioral abnormalities, and psychological disorders. We present a patient who suffered psychosis related to disconnection of the limbic system...
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Restoration of the Spinous Process Following Muscle-Preserving Posterior Lumbar Decompression via Sagittal Splitting of the Spinous Process

Wi SM, Lee HJ, Chang SY, Kwon OH, Lee CK, Chang BS, Kim H

BACKGROUND: In lumbar spinal stenosis, spinous process-splitting decompression has demonstrated good clinical outcomes with preservation of the posterior ligamentous complex and paraspinal muscles in comparison to conventional laminectomy, but the...
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The Role of Plasmacytoid Dendritic Cells in Gut Health

Won HY, Lee JY, Ryu D, Kim HT, Chang SY

Plasmacytoid dendritic cells (pDCs) are a unique subset of cells with different functional characteristics compared to classical dendritic cells. The pDCs are critical for the production of type I IFN...
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Clinical Significance of Resection Type and Margin following Surgical Treatment for Primary Sarcoma of the Spine: A Multi-Center Retrospective Study

Chang SY, Kim H, Park SJ, Chang BS, Lee CS, Lee CK

STUDY DESIGN: A retrospective multi-center study. OBJECTIVES: To analyze oncological outcomes according to the resection type and surgical margin following surgical treatment for primary spinal sarcoma. SUMMARY OF LITERATURE REVIEW: Previous studies...
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Antipruritic effect of curcumin on histamine-induced itching in mice

Lee HK, Park SB, Chang SY, Jung SJ

Itching is a common clinical symptom of skin disease that significantly affects a patient's quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers...
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Tissue-specific Role of CX₃CL1 Expressing Immune Cells and Their Relationships with Human Disease

Lee M, Lee Y, Song J, Lee J, Chang SY

Chemokine (C-X3-C motif) ligand 1 (CX₃CL1, also known as fractalkine) and its receptor chemokine (C-X3-C motif) receptor 1 (CX₃CR1) are widely expressed in immune cells and non-immune cells throughout organisms....
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Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection

Song JH, Shim A, Kim YJ, Ahn JH, Kwon BE, Pham TT, Lee J, Chang SY, Ko HJ

Human rhinoviruses (HRV) are one of the major causes of common cold in humans and are also associated with acute asthma and bronchial illness. Heat-shock protein 90 (Hsp90), a molecular...
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Prognosis of Single Spinal Metastatic Tumors: Predictive Value of the Spinal Instability Neoplastic Score System for Spinal Adverse Events

Chang SY, Ha JH, Seo SG, Chang BS, Lee CK, Kim H

STUDY DESIGN: This was a retrospective cohort study. PURPOSE: We evaluated the predictive value of the Spinal Instability Neoplastic Score (SINS) system for spinal adverse events (SAEs) in patients with single...
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Enterovirus 71 infection and vaccines

Yi EJ, Shin YJ, Kim JH, Kim TG, Chang SY

Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting young children during the spring to fall seasons. Recently, serious outbreaks of HFMD were reported frequently in...
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Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease

Kim YJ, Chang SY, Ko HJ

Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs), include neutrophilic and monocytic myeloid cells, and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal...
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Regulation of Intestinal Immune System by Dendritic Cells

Ko HJ, Chang SY

Innate immune cells survey antigenic materials beneath our body surfaces and provide a front-line response to internal and external danger signals. Dendritic cells (DCs), a subset of innate immune cells,...
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High Malaria Prevalence among Schoolchildren on Kome Island, Tanzania

Kim MJ, Jung BK, Chai JY, Eom KS, Yong TS, Min DY, Siza JE, Kaatano GM, Kuboza J, Mnyeshi P, Changalucha JM, Ko Y, Chang SY, Rim HJ

In order to determine the status of malaria among schoolchildren on Kome Island (Lake Victoria), near Mwanza, Tanzania, a total of 244 schoolchildren in 10 primary schools were subjected to...
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Improved Perceptions and Practices Related to Schistosomiasis and Intestinal Worm Infections Following PHAST Intervention on Kome Island, North-Western Tanzania

Mwanga JR, Kaatano GM, Siza JE, Chang SY, Ko Y, Kullaya CM, Nsabo J, Eom KS, Yong TS, Chai JY, Min DY, Rim HJ, Changalucha JM

Schistosomiasis and intestinal worm infections are widespread diseases of public health importance in Tanzania. A study on perceptions and practices related to schistosomiasis and intestinal worm infections was undertaken among...
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Improved Socio-Economic Status of a Community Population Following Schistosomiasis and Intestinal Worm Control Interventions on Kome Island, North-Western Tanzania

Mwanga JR, Kaatano GM, Siza JE, Chang SY, Ko Y, Kullaya CM, Nsabo J, Eom KS, Yong TS, Chai JY, Min DY, Rim HJ, Changalucha JM

Research on micro-level assessment of the changes of socio-economic status following health interventions is very scarce. The use of household asset data to determine wealth indices is a common procedure...
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Schistosoma mansoni-Related Hepatosplenic Morbidity in Adult Population on Kome Island, Sengerema District, Tanzania

Kaatano GM, Min DY, Siza JE, Yong TS, Chai JY, Ko Y, Chang SY, Changalucha JM, Eom KS, Rim HJ

Schistosomiasis is one of the important neglected tropical diseases (NTDs) in Tanzania, particularly in Lake Victoria zone. This baseline survey was a part of the main study of integrated control...
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Integrated Schistosomiasis and Soil-Transmitted Helminthiasis Control over Five Years on Kome Island, Tanzania

Kaatano GM, Siza JE, Mwanga JR, Min DY, Yong TS, Chai JY, Ko Y, Chang SY, Kullaya CM, Rim HJ, Changalucha JM, Eom KS

Integrated control strategies are important for sustainable control of schistosomiasis and soil-transmitted helminthiasis, despite their challenges for their effective implementation. With the support of Good Neighbors International in collaboration with...
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