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Clinical Outcomes Following Letrozole Treatment according to Estrogen Receptor Expression in Postmenopausal Women: LETTER Study (KBCSG-006)

Ahn SG, Nam SJ, Ahn SH, Jung Y, Park HK, Lee SJ, Kang SS, Han W, Park KH, Park YL, Lee J, Youn HJ, Kim JH, Yoo Y, Song JY, Ko BK, Gwak G, Chung MS, Kim SY, Cho SH, Kim D, Chang MC, Moon BI, Kim LS, Kim SJ, Park MH, Kim TH, Cho J, Lim CW, Bae YT, Gong G, Bae YK, Lee A, Jeong J

Purpose: In this trial, we investigated the efficacy and safety of adjuvant letrozole for hormone receptor (HR)-positive breast cancer. Here, we report the clinical outcome in postmenopausal women with HR-positive...
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Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A

Shong KE, Oh CM, Namkung J, Park S, Kim H

Background: Obesity is defined as excessive fat mass and is a major cause of many chronic diseases such as diabetes, cardiovascular disease, and cancer. Increasing energy expenditure and regulating adipose...
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Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease

Oh CM, Ryu D, Cho S, Jang Y

Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP...
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Successful Management of Visceral Kaposiform Hemangioendothelioma with Kasabach‐Merritt Phenomenon Using Corticosteroids and Vincristine

Gang MH, Lim YJ, Chang My

Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular neoplasm that often develops a coagulopathy known as Kasabach­Merritt phenomenon (KMP). Visceral involvement denotes a poor prognosis. We report a case...
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Perspective of Nationwide Surveillance System for Healthcareassociated Infection in Neonatal Intensive Care Units

Kim AR, Kim EJ, Kim CS, Park MS, Park JY, Shim GH, Eun BW, Lee B, Chang MY, Choi SH, Choi JH

Healthcare-associated infection (HAI) is one of the most important causes of neonatal morbidity and mortality. The latest developments in neonatal care have greatly improved the neonatal outcomes. Nevertheless, preterm infants,...
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Leri-Weill dyschondrosteosis in a newborn presenting with respiratory failure due to severe micrognathia

Gang MH, Lee J, Lee YW, Shin JH, Lim HH, Kim YM, Chang My

Short stature homeobox-containing gene (SHOX) is a well-known causative gene for the short stature in Turner syndrome. The clinical manifestation of SHOX gene related disorders varies from SHOX haploinsufficiency, presenting...
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Clinical Characteristics and Outcomes of Mothers and Newborn Babies at an Inte grated Perinatal Center for High-risk Preg nancy and Neonatal Care

Park Y, Gang MH, Lee YW, Kang BH, Lee MA, Chang My

Objective: The appropriate perinatal care and safe delivery of high-risk pregnant women have a sig nificant impact on the prognosis of newborn. The purpose of this study is to analyze...
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Urinary Iodine Concentration and Thyroid Peroxidase Antibodies in the Korean Population Using Korea National Health and Nutrition Examination Survey VI

Chang MC

Background and Objectives: This study was planned to investigate the relationship between iodine intake and thyroid peroxidase antibody in Korean population. Materials and Methods: We used the data of the...
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Myeloproliferative Neoplasm in Newly Diagnosed Acute Ischemic Stroke Patients

Chang MH, Lee JE, Lee MY, Kim KH

OBJECTIVE: Myeloproliferative neoplasm (MPN) is considered as one of the risk factors of ischemic stroke. Some MPN patients manifest stroke as their first symptom. Our purpose was to assess diagnostic...
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Twenty-one-year follow-up of variable onset MELAS syndrome with heteroplasmic nt3243A>G mtDNA mutation: A case report

Song WJ, Lee YJ, Kang JW, Chang MY, Song KS, Kang DY, Kim SZ

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disorder of which m.3243A>G is the most commonly associated mutation, resulting in an inability to meet...
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Losartan Prevents Maladaptive Auditory-Somatosensory Plasticity After Hearing Loss via Transforming Growth Factor-β Signaling Suppression

Mun SK, Han KH, Baek JT, Ahn SW, Cho HS, Chang MY

OBJECTIVES: Hearing loss disrupts the balance of auditory-somatosensory inputs in the cochlear nucleus (CN) of the brainstem, which has been suggested to be a mechanism of tinnitus. This disruption results...
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Robotic and Endoscopic Thyroid Surgery: Evolution and Advances

Tae K, Ji YB, Song CM, Ryu J

To minimize surgical morbidity and neck scarring, minimally invasive thyroidectomy and robotic/endoscopic thyroidectomy via cervical, axillary, anterior chest, breast, postauricular or transoral approaches have been developed over the past 20...
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Intrathyroidal Parathyroid Carcinoma in Chronic Kidney Disease: A Case Report and Review of Literature

Kim MK, Song CM, Tae K, Ji YB

When parathyroid carcinoma occurs in the thyroid gland, it is very difficult to diagnose before surgery because imaging studies and aspiration cytology cannot distinguish parathyroid carcinoma from thyroid nodule or...
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Trisomy 12p Syndrome Secondary to a Balanced Maternal Translocation [46,XX, t(12;22)(p11.2;p13)]

Gang MH, Lee YW, Lim HH, Chang MY

Trisomy 12p is a rare chromosomal anomaly. It causes dysmorphic features, multiple congenital anomalies, neonatal complications, and mental retardation. We present a case of complete and pure trisomy 12p syndrome...
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Cardioprotective Potential of an SGLT2 Inhibitor Against Doxorubicin-Induced Heart Failure

Oh CM, Cho S, Jang JY, Kim H, Chun S, Choi M, Park S, Ko YG

BACKGROUND AND OBJECTIVES: Recent studies have shown that sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of heart failure (HF)-associated hospitalization and mortality in patients with diabetes. However, it is...
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A Case of Laryngeal Inflammatory Myofibroblastic Tumor

Park SG, Kim Y, Woong JH, Song CM

Inflammatory myofibrolastic tumor (IMT) is a rare borderline neoplasm. It frequently occurs in the lung but occasionally occurs in extrapulmonary sites such as the genitourinary tract, gastrointestinal tract, breast, salivary...
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Clinical Characteristics of Infectious Mononucleosis: A Retrospective Study

Kim KH, Kang HJ, Lee SJ, Song CM, Ji YB, Tae K

BACKGROUND AND OBJECTIVES: Infectious mononucleosis is mainly caused by Epstein-Barr virus infection and it presents sore throat, fever, tonsillar enlargement with exudate, cervical lymphadenopathy, hepatosplenomegaly, and etc. Therefore, it is...
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Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3

Lee K, Kim H, Lee J, Oh CM, Song H, Kim H, Koo SH, Lee J, Lim A, Kim H

BACKGROUND: Protein arginine methyltransferase 1 (PRMT1) is a major enzyme responsible for the formation of methylarginine in mammalian cells. Recent studies have revealed that PRMT1 plays important roles in the...
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Dual-Layer Spectral Detector CT Discography of the Lumbar Spine: A Preliminary Study

Chae HD, Hong SH, Choi JY, Yoo HJ, Moon SJ, Chang MY

PURPOSE: To assess the feasibility of spectral detector CT (SDCT) with axial maximum-intensity projection (MIP) reconstruction for the evaluation of lumbar CT discography. MATERIALS AND METHODS: We retrospectively evaluated 44 disc...
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Pfeiffer Syndrome Type 2 with Sporadic Fibroblast Growth Factor Receptor 2 Mutation and Coccygeal Anomaly

Lee JS, Choi JH, Lee YW, Gang MH, You SK, Shin HD, Chang MY

Pfeiffer syndrome is a rare genetic disorder characterized by premature fusion of certain skull bones (craniosynostosis) and anomalies of the face and extremities. A female newborn showing ocular proptosis and...
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