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Age-related Effects of Heroin on Gene Expression in the Hippocampus and Striatum of Cynomolgus Monkeys

Choi MR, Jin YB, Bang SH, Im CN, Lee Y, Kim HN, Chang KT, Lee SR, Kim DJ

Objective: The aim of this study was to investigate differentially expressed genes and their functions in the hippocampus and striatum after heroin administration in cynomolgus macaques of different ages. Methods: Cynomolgus...
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Adult Stem Cells in Hibernation: Future Perspectives of Space Travel

Chen YC, Aui SP, Lai YS, Chang KT

Space traveling is imperative for mankind in the future. Expectedly, hibernation will become an option for space traveler to overcome the endless voyage. With regard to some of the studies...
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Aristolochia manshuriensis Kom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse

Kwak DH, Kim JS, Chang KT, Choo YK

Aristolochia manshuriensis Kom (AMK) is an herb used as a traditional medicine; however, it causes side effects such as nephrotoxicity and carcinogenicity. Nevertheless, AMK can be applied in specific ways...
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Epigenetic regulation in allergic diseases and related studies

Kuo CH, Hsieh CC, Lee MS, Chang KT, Kuo HF, Hung CH

Asthma, a chronic inflammatory disorder of the airway, has features of both heritability as well as environmental influences which can be introduced in utero exposures and modified through aging, and...
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Acute gastrointestinal dilation in laboratory rhesus monkeys in the Korea National Primate Research Center

Kim KM, Lee SR, Chang KS, Lee YH, Kim SW, Jung KJ, Lee Y, Kim D, Chang KT

Acute gastrointestinal dilation is a medical condition in which the stomach and intestine become overstretched by excessive gas content. In laboratory monkeys, cases of bloating involving gastrointestinal dilation are rarely...
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Prophylactic effects of swimming exercise on autophagy-induced muscle atrophy in diabetic rats

Lee Y, Kim JH, Hong Y, Lee SR, Chang KT, Hong Y

Diabetes decreases skeletal muscle mass and induces atrophy. However, the mechanisms by which hyperglycemia and insulin deficiency modify muscle mass are not well defined. In this study, we evaluated the...
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Autophagy contributes to retardation of cardiac growth in diabetic rats

Lee Y, Hong Y, Lee SR, Chang KT, Hong Y

Diabetes mellitus is a major predictor of heart failure, although the mechanisms by which the disease causes cardiomyopathy are not well understood. The purpose of this study was to determine...
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Beneficial effects of melatonin on stroke-induced muscle atrophy in focal cerebral ischemic rats

Lee S, Shin J, Hong Y, Lee M, Kim K, Lee SR, Chang KT, Hong Y

  • KMID: 2312092
  • Lab Anim Res.
  • 2012 Mar;28(1):47-54.
Muscle atrophy is the result of two opposing conditions that can be found in pathological or diseased muscles: an imbalance in protein synthesis and degradation mechanisms. Thus, we investigated whether...
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Differential expression of caveolins and myosin heavy chains in response to forced exercise in rats

Park S, Hong Y, Lee Y, Won J, Chang KT, Hong Y

  • KMID: 2312086
  • Lab Anim Res.
  • 2012 Mar;28(1):1-9.
Exercise training can improve strength and lead to adaptations in the skeletal muscle and nervous systems. Skeletal muscles can develop into two types: fast and slow, depending on the expression...
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Human leukocytes regulate ganglioside expression in cultured micro-pig aortic endothelial cells

Cho JH, Kim JS, Lim MU, Min HK, Kwak DH, Ryu JS, Lee JT, Kim SU, Kim CH, Kim CH, Koo DB, Chang KT, Choo YK

Gangliosides are ubiquitous components of the membranes of mammalian cells that are thought to play important roles in various cell functions such as cell-cell interaction, cell adhesion, cell differentiation, growth...
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Roles of gangliosides in mouse embryogenesis and embryonic stem cell differentiation

Kwak DH, Seo BB, Chang KT, Choo YK

Gangliosides have been suggested to play important roles in various functions such as adhesion, cell differentiation, growth control, and signaling. Mouse follicular development, ovulation, and luteinization during the estrous cycle...
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Rectal Prolapse Associated with Recurrent Diarrhea in a Laboratory Cynomolgus Monkey (Macaca fascicularis)

Lee SR, Lee YH, Kim KM, Kim SW, Jung KJ, Kim YH, Son HY, Chang KT

Rectal prolapse is a protrusion of one or more layers of the rectum through the anus. A 5-year-old laboratory cynomolgus monkey who had suffered from recurrent diarrhea died after surgical...
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The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells

Jung JU, Ko K, Lee DH, Ko K, Chang KT, Choo YK

Glycosphingolipids including gangliosides play important regulatory roles in cell proliferation and differentiation. UDP-glucose:ceramide glucosyltransferase (Ugcg) catalyze the initial step in glycosphingolipids biosynthesis pathway. In this study, Ugcg expression was reduced...
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