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Clinical Outcomes of Second-Line Chemotherapy after Progression on Nab-Paclitaxel Plus Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

Lee K, Bang K, Yoo C, Hwang I, Jeong JH, Chang HM, Oh D, Song TJ, Park DH, Lee SS, Lee SK, Kim MH, Park Jh, Kim Kp, Ryoo BY

Purpose Since the introduction of nab-paclitaxel plus gemcitabine (nab-P+GEM) as first-line (1L) treatment for metastatic pancreatic adenocarcinoma (mPDAC), optimal second-line (2L) chemotherapy after progression is unclear. We assessed clinical outcomes of...
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Clinical Benefit of Maintenance Therapy for Advanced Biliary Tract Cancer Patients Showing No Progression after First-Line Gemcitabine Plus Cisplatin

Hyung J, Kim B, Yoo C, Kim KP, Jeong JH, Chang HM, Ryoo BY

PURPOSE: Gemcitabine plus cisplatin (GemCis) is the standard first-line chemotherapy for patients with advanced biliary tract cancer (BTC). In ABC-02 study, the BTC patients received up to 6-8 cycles of...
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Inhibition of Osteoclast differentiation based on precipitation time of titanium surfaces immersed in modified simulated body fluid

Chang HM, Heo SJ, Kim SK, Koak JY

PURPOSE: The purpose of this study is to investigate the changes of osteoclast differentiation inhibition according to the period of precipitation when titanium disks were immersed in Modified simulated body...
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Multicenter Phase II Study of Oxaliplatin, Irinotecan, and S-1 as First-line Treatment for Patients with Recurrent or Metastatic Biliary Tract Cancer

Yoo C, Han B, Kim HS, Kim KP, Kim D, Jeong JH, Lee JL, Kim TW, Kim JH, Choi DR, Ha HI, Seo J, Chang HM, Ryoo BY, Zang DY

PURPOSE: Although gemcitabine plus cisplatin has been established as the standard first-line chemotherapy for patients with advanced biliary tract cancer (BTC), overall prognosis remains poor. We investigated the efficacy of...
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Efficacy of Chemotherapy in Patients with Unresectable or Metastatic Pancreatic Acinar Cell Carcinoma: Potentially Improved Efficacy with Oxaliplatin-Containing Regimen

Yoo C, Kim BJ, Kim KP, Lee JL, Kim TW, Ryoo BY, Chang HM

PURPOSE: Pancreatic acinar cell carcinoma (ACC) is a rare cancer of the exocrine pancreas. Because of its rare incidence, the efficacy of chemotherapy in this patient population has been largely...
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Preoperative chemoradiotherapy followed by local excision in clinical T2N0 rectal cancer

Shin YS, Yoon YS, Lim SB, Yu CS, Kim TW, Chang HM, Park JH, Ahn SD, Lee SW, Choi EK, Kim JC, Kim JH

PURPOSE: To investigate whether preoperative chemoradiotherapy (PCRT) followed by local excision (LE) is feasible approach in clinical T2N0 rectal cancer patients. MATERIALS AND METHODS: Patients who received PCRT and LE because...
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Consensus Guideline for Advanced Pancreatic Neuroendocrine Tumor

Chang HM

  • KMID: 2258970
  • Korean J Med.
  • 2011 Apr;80(4):393-396.
The goals of medical treatment for advanced pancreatic neuroendocrine tumor (PNET) are to control hormone-related symptoms and to prolong overall survival. Somatostatin analogues have been used for decreasing the secretion...
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Treatment outcome of postoperative radiotherapy for retroperitoneal sarcoma

Lee HJ, Song SY, Kwon TW, Yook JH, Kim SC, Han DJ, Kim CS, Ahn H, Chang HM, Ahn JH, Jwa EJ, Lee SW, Kim JH, Choi EK, Shin SS, Ahn SD

PURPOSE: To evaluate the treatment outcome and prognostic factor after postoperative radiotherapy in retroperitoneal sarcoma. MATERIALS AND METHODS: Forty patients were treated with surgical resection and postoperative radiotherapy for retroperitoneal sarcoma...
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Relationship between Obesity and Depression in the Korean Working Population

Kim JY, Chang HM, Cho JJ, Yoo SH, Kim SY

This study was conducted to investigate potential relationship between obesity and depression in Korean working population. A total of 8,121 workers, aged 21-75 yr, participated in this nationwide cross-section research....
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Relationship between Brand Nicotine Yield of Cigarettes and Urine Cotinine Level in Male Smokers

Yoon SH, Paek YJ, Yoo SH, Cho JJ, Song HJ, Park KH, Chang HM, Ban JH

BACKGROUND: As one of harm reduction strategies, tobacco manufacturers have begun to introduce lower-yield cigarettes. Lower-yield cigarettes, so called light cigarettes, have been perceived as less hazardous by some smokers....
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EC-18, a Synthetic Monoacetyldiacylglyceride, Inhibits Hematogenous Metastasis of KIGB-5 Biliary Cancer Cell in Hamster Model

Kim MH, Chang HM, Kim TW, Lee SK, Park JS, Kim YH, Lee TY, Jang SJ, Suh CW, Lee TS, Kim SH, Lee SG

EC-18 (monoacetyldiacylglyceride) stimulates T cell production of IL-2, IL-4, IL-12, IFN-gamma, and GM-CSF in vitro. To study the effects of these cytokines stimulated by EC-18 on cancer cells, we applied...
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The Results of Postoperative Radiation Therapy for Perihilar Cholangiocarcinoma

Lee YS, Park JW, Park JH, Choi EK, Ahn SD, Lee SW, Song SY, Lee SG, Hwang S, Lee YJ, Park KM, Kim KH, Ahn CS, Moon DB, Chang HM, Ryu MH, Kim TW, Lee JL, Kim JH

PURPOSE: The aim of this study was to evaluate the results of postoperative radiotherapy in a case of perihilar cholagiocarcinoma by analyzing overall survival rate, patterns of failure, prognostic factors...
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Association between Depression and Cardiovascular Risk Factors in Workers Undergoing Comprehensive Medical Examination in a University-based Hospital

Choi JW, Cho JJ, Chang HM, Kim CW, Paek YJ, Song HJ, Park KH, Choi W

  • KMID: 2294410
  • J Korean Acad Fam Med.
  • 2008 Sep;29(9):645-650.
BACKGROUND: Depression increases the risk of cardiovascular risk factors in adults. However, the association between depression and cardiovascular risk factors was not well evaluated in South Korea. Our study was...
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Percent Body Fat and Abdominal Circumference Cutoff Points Accounted for 85th and 95th Percentile of Body Mass Index in One City of Gyeonggi Province

Kim CW, Park KH, Ju YS, Song HJ, Paek YJ, Choi JW, Chang HM, Cho JJ

  • KMID: 2294428
  • J Korean Acad Fam Med.
  • 2008 Jul;29(7):492-498.
BACKGROUND: Childhood obesity is becoming more prevalent, associated with a variety of adverse consequences which leads to adulthood obesity. Although diagnosis is usually made by body mass index, there is...
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A Phase II Study of Cetuximab (Erbitux(R)) plus FOLFIRI for Irinotecan and Oxaliplatin-refractory Metastatic Colorectal Cancer

Koo DH, Lee JL, Kim TW, Chang HM, Ryu MH, Lee SS, Kim MK, Sym SJ, Lee JS, Kang YK

We have evaluated the efficacy and safety of cetuximab plus FOLFIRI for irinotecan and oxaliplatin-refractory colorectal cancers. From September 2004 to February 2006, 31 patients with metastatic colorectal cancer were...
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Characteristics of Chronic Sensory Abnormalities in Korean Burn Patients

Kim HS, Chang HM, Choi DY, Woo CH, Mun SH, Kim HS, Kim KM

BACKGROUND: After burn patients are discharged from the hospital, they may continue to feel pain and paresthetic sensations at the site of a healed burn and these problems may persist...
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Distant Metastasis Identified Immediately after Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer

Park IJ, Kim HC, Yu CS, Choi PH, Jung SH, Hong DH, Kim DD, Ryu MH, Chang HM, Kim JH, Kim JC

  • KMID: 2334398
  • J Korean Soc Coloproctol.
  • 2007 Oct;23(5):327-332.
PURPOSE: This study was designed to analyze the clinical characteristics of patients with immediate distant metastasis after preoperative chemoradiotherapy for locally advanced rectal cancer and to help select patients for...
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Clinicopathologic Characteristics of Colorectal Neuroendocrine Tumor

Jung SH, Kim HC, Yu CS, Chang HM, Ryu MH, Lee JL, Kim JS, Kim JC

  • KMID: 782747
  • Korean J Gastroenterol.
  • 2006 Aug;48(2):97-103.
BACKGROUND/AIMS: Colorectal neuroendocrine carcinoma is a rare neoplasm exhibiting fulminant progression and having poor prognosis. The purpose of this study is to verify the clinicopathologic characteristics of colorectal neuroendocrine carcinoma....
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Neoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors of the Stomach: Report of Three Cases

Oh JS, Lee JL, Kim MJ, Ryu MH, Chang HM, Kim TW, Jang SJ, Yook JH, Oh ST, Kim BS, Kang YK

  • KMID: 2166063
  • Cancer Res Treat.
  • 2006 Jun;38(3):178-183.
Neoadjuvant imatinib therapy used to treat locally advanced or metastatic gastrointestinal stromal tumors (GI ST) remains under active investigation. We studied three cases of locally advanced gastric GISTs treated with...
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A case of intrahepatic cholangiocarcinoma with orbital metastasis

Heo NY, Lee JL, Ryu MH, Chang HM, Kang YK, Lee JK, Yu E

  • KMID: 2252419
  • Korean J Med.
  • 2006 Mar;70(3):337-341.
Orbital lesions may be the presenting sign of a systemic disease, such as a metastatic cancer. A metastatic cancer of the orbit, which has been reported to account for 2~3%...
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