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Modern History of Hansen's Disease in Korea

Chae GT

Modern history of Hansen's Disease (HD) in Korea begins with nationwide use of the chemotherapeutic agent Diamino Diphenyl Sulphone for the patients in 1955. Definition of the case was different...
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Expression of Nucleotide-oligomerization Domain (NOD) and Related Genes in Mouse Tissues Infected with Mycobacterium leprae

Kim TH, Chae GT, Kang TJ

The nucleotide-oligomerization domain (NOD) is an important molecule involved in host defense against bacterial infection. To study the role of NODs in the host response to Mycobacterium leprae, we measured...
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The Role of Intracellular Receptor NODs for Cytokine Production by Macrophages Infected with Mycobacterium leprae

Kang TJ, Chae GT

The nucleotide-oligomerization domain (NOD) proteins are members of the NOD-like receptor (NLR) family, which are intracellular and cytoplasmic receptors. We analyzed the role of NODs for cytokine production by macrophages...
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Vitamin D Receptor Gene TaqI, BsmI and FokI Polymorphisms in Korean Patients with Tuberculosis

Kang TJ, Jin SH, Yeum CE, Lee SB, Kim CH, Lee SH, Kim KH, Shin ES, Chae GT

BACKGROUND: The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to activation of macrophages and deficiency of vitamin D seems to be involved in the risk of tuberculosis. The...
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Rifampicin Inhibits the LPS-induced Expression of Toll-like Receptor 2 via the Suppression of NF-kappaB DNA-binding Activity in RAW 264.7 Cells

Kim SK, Kim YM, Yeum CE, Jin SH, Chae GT, Lee SB

Rifampicin is a macrocyclic antibiotic which is used extensively for treatment against Mycobacterium tuberculosis and other mycobacterial infections. Recently, a number of studies have focused on the immune-regulatory effects of...
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Comparison of rpoT gene of M. leprae strain from korean and foreign leprosy patients

Kang TJ, Kim SK, Kim NH, Matsuoka M, Chae GT

  • KMID: 1993560
  • Korean Lepr Bull.
  • 2004 Jul;37(1):3-14.
The variance of tandem repeats in the rpoT gene of Mycobacterium leprae was recently demonstrated. The objects of this study was to examine the proportion and distributions of the genotypes...
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Detection of point mutation at C-terminal region of phagosomal coat protein (TACO) in patients with leprosy

Kim SK, Kang TJ, Kim BC, Chae GT

  • KMID: 1516979
  • Korean Lepr Bull.
  • 2003 Jul;36(1):11-26.
Mycobacteria, which are highly successful pathogen, resist delivary to lysosomes and instead survive within a specialized vacuole, the mycobacterial phagosome. The bacteria survive intracellularly because they are able to actively...
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Mutations in folP1, rpoB, and gyrB associated with multiple drug resistance in Mycobacterium leprae isolates from South Korea

Lee SB, You EY, Kang TJ, Kim SK, Kim JP, Ko YH, Chae GT

  • KMID: 1516978
  • Korean Lepr Bull.
  • 2003 Jul;36(1):3-9.
The emergence of multiple drug resistant Mycobacterium leprae has emphasized the need for early decision of effective antileprosy drug in the treatment for leprosy patients. Mutations in the genes associated...
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The association study on infection of Mycobacterium leprae and RIPK2

Kim BC, Kang TJ, Chae GT

  • KMID: 1921046
  • Korean Lepr Bull.
  • 2003 Dec;36(2):23-29.
Receptor-interacting serine/threonine kinase 2(RIPK2) is an adaptor molecule involved in the signal pathway of TLRs. However, there is no report on association between RIPK2 expression and infectious disease including...
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Differentiation of Osteoblast Progenitor Cells from Human Umbilical Cord Blood

Hong SJ, Lee EA, Chae GT, Han H

BACKGROUND: Human umbilical cord bloods, which could be taken during the delivery are utilized as a source of hematopoietic stem cells. Also in cord blood, there are several kinds of...
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The Development Tasks of Medical School Accreditation in Korea

Lee MS, Suh DJ, Yang EB, Chai JY, Chae GT, Ahn DS, Kim DG

  • KMID: 2306871
  • Korean J Med Educ.
  • 2002 May;14(1):73-83.
The Accreditation Board for Medical Education in Korea, ABMEK, is nongovernmental appraisal organization that was established at July 2, 1998. The organization is contributing to the improvement of medical education...
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Effects of Dexamethasone on expressions of IFN-gamma and IL-4 by PBMCs in response to IL-12

Heo SH, Lee SB, Chae GT

  • KMID: 2053859
  • Korean Lepr Bull.
  • 2002 Dec;35(2):3-12.
Dexamethasone is a widely used anti-inflammatory agent for a broad spectrum of diseases. The effectiveness of this agent is thought to be due to the capacity to modulate cytokine production...
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Optimization for cell lysate preparation of M. leprae from infected nude mouse

Kang TJ, Lee SB, Chae GT

  • KMID: 2139271
  • Korean Lepr Bull.
  • 2001 Jun;34(1):47-56.
The method of cell lysate preparation of M. leprae is an important technique in the study of leprosy. This report describes the optimization of method for cell lysate preparation of...
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Changes of Leprosy Research in the Post Genomic Era

Chae GT

  • KMID: 2139268
  • Korean Lepr Bull.
  • 2001 Jun;34(1):3-12.
Leprosy has turned out to be a minor health problem in Korea due to implementation of multidrug therapy, intensive case detection and mobile works for the villages for last 20...
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The Change of Bacillary Index during WHO Standard Multi-drug Therapy in Multi-bacillary Leprosy: Among the patients in The National Sorokdo Hospital

Lee JH, Kim DH, Choi SW, Kim HO, Chae GT, Kim TY

  • KMID: 1595047
  • Korean J Dermatol.
  • 2001 Mar;39(3):318-322.
BACKGROUND: There were no effective methods to monitor the treatment of leprosy. Anti-PGL-1 ELISA test and polymerase chain reaction(PCR) were used for monitoring the treatment, however many restrictions have been...
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The application of TD (Touch-Down) PCR in Diagnosis of leprosy and Detection of MDT-resistant M. leprae

Kim SK, Lee SB, Kang TJ, Chae GT

  • KMID: 1609921
  • Korean Lepr Bull.
  • 2001 Dec;34(2):13-21.
There are several methods for diagnosis of leprosy, including AFB stain, the measurement of PGL-1 (phenolic glycolipid - 1) antigen titer, and DNA-PCR. In this study, we have used the...
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The effect of TLR2 mutation in IL-12 production according to type of leprosy

Kang TJ, Lee SB, Chae GT

  • KMID: 1609918
  • Korean Lepr Bull.
  • 2001 Dec;34(2):3-12.
Recently, many reports suggest that the activation of Toll-like receptor 2 (TLR2) by microbial lipoproteins may initiate innate defense mechanism against infectious pathogens. Especially, TLR2 is critical in the immune...
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Identification of regulatory sequence within the promoter of M.leprae-specific 18-kDa gene and its binding factor(s)

Kim MJ, Kim YK, Chae GT

  • KMID: 2139281
  • Korean Lepr Bull.
  • 2000 Jun;33(1):107-113.
A central question to the pathogenesis of leprosy is how Mycobacterium leprae, the causative agent of leprosy, survives and replicates within macrophages. 18-kDa protein of M. leprae, a major antigen,...
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Past, Present And Future Strategies For Hansen's Disease In Korea

Chae GT

  • KMID: 2139276
  • Korean Lepr Bull.
  • 2000 Jun;33(1):39-57.
To prepare the postelimination phase of Hansen's disease in Korea, it is mandatory to review antileprosy strategies that we have pursued in the past, present and future in medical aspects...
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HLA-A, B and DRB1 Genes Related with Susceptibility and Type of Hansen's Disease

Chae GT, Lee SB, Kang TJ, Kim JP, Ko YH

  • KMID: 1584951
  • Korean Lepr Bull.
  • 2000 Dec;33(2):67-78.
To find out whether the susceptibility to Hansen's disease are associated with HLA genes, serological and nucleotide typing of HLA-A, B, and DRB1 alleles have been conducted in 301 Hansen's...
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