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Clinical outcomes of the first 300 cases of kidney transplantation: a single-center retrospective cohort study

Koh HW, Koo K, Shin CS, Park HS, Jeong JC, Kim S, Chae DW, Oh JJ, Byun SS, Lee T

Background: Kidney transplantation (KT) is regarded as the most effective treatment for end-stage renal disease. The annual number of KT cases in South Korea has increased rapidly as more centers...
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The KNOW-CKD Study: What we have learned about chronic kidney diseases

Oh KH, Kang M, Kang E, Ryu H, Han SH, Yoo TH, Kim SW, Chae DW, Lee KB, Park SK, Kim YH, Ahn C, the KNOW-CKD Study Investigators

As the nation’s largest chronic kidney disease (CKD) cohort, the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) was established to investigate the clinical course, risk...
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Development and validation of an algorithm to estimate eplet mismatch by substituting imputation of HLA antigens for highresolution HLA typing based on Korean HLA frequencies

Kim SK, Park BG, Son HE, Jeong JC, Hong YJ, Chae DW

Background: Assessment of eplet mismatches in transplantation requires high-resolution (HR) molecular human leukocyte antigen (HLA) typing. However, HR typing is rarely applied to solid organ transplantation. We developed an algorithm...
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Optimal systolic blood pressure in noncritically ill patients with acute kidney injury: A retrospective cohort study

Baek SH, Chin HJ, Na KY, Chae DW, Kim S

BACKGROUND: Few data showed the optimal blood pressure (BP) in noncritically ill patients with acute kidney injury (AKI) relative to mortality or severe AKI. We therefore sought to analyze the...
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Severe Hypocalcemia in a Patient with Tuberous Sclerosis Complex

Kim K, Kim S, Na KY, Chae DW, Chin HJ

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder affecting multiple organs, including the brain, skin, lung, and kidney. Among the multiple comorbidities in TSC, bone mineral disturbances remain...
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Clinical Usefulness of Unenhanced Computed Tomography in Patients with Acute Pyelonephritis

Lee A, Kim HC, Hwang SI, Chin HJ, Na KY, Chae DW, Kim S

BACKGROUND: Unenhanced computed tomography (UCT) may be useful for evaluating acute pyelonephritis; however, no study has compared UCT with enhanced computed tomography (ECT) as a diagnostic tool. We evaluated a...
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Nutritional Status in Adults with Predialysis Chronic Kidney Disease: KNOW-CKD Study

Hyun YY, Lee KB, Han SH, Kim YH, Kim YS, Lee SW, Oh YK, Chae DW, Ahn C

Adverse changes in nutrition are prevalent and are strong indicators of adverse outcomes in patients with chronic kidney disease (CKD). The International Society of Renal Nutrition and Metabolism (ISRNM) proposed...
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Chronic Kidney Disease-Mineral Bone Disorder in Korean Patients: a Report from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)

Kim CS, Bae EH, Ma SK, Han SH, Lee KB, Lee J, Oh KH, Chae DW, Kim SW, Representatives of the KNOW-CKD Study Group

This study examined the characteristics of biochemical parameters, bone diseases, and vascular calcification in Korean patients with chronic kidney disease (CKD) not yet on dialysis. Serum levels of fibroblast growth...
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Quantitative Single-Photon Emission Computed Tomography/Computed Tomography for Glomerular Filtration Rate Measurement

Kang YK, Park S, Suh MS, Byun SS, Chae DW, Lee WW

PURPOSE: We propose a quantitative Tc-99m diethylenetriaminepentaacetic acid (DTPA) single-photon emission computed tomography/computed tomography (SPECT/CT) for glomerular filtration rate (GFR) measurement. METHODS: Quantitative SPECT/CT data obtained at 2–3 min post-Tc-99m DTPA...
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Is Frailty a Modifiable Risk Factor of Future Adverse Outcomes in Elderly Patients with Incident End-Stage Renal Disease?

Lee SW, Lee A, Yu MY, Kim SW, Kim KI, Na KY, Chae DW, Kim CH, Chin HJ

Little is known about the clinical significance of frailty and changes of frailty after dialysis initiation in elderly patients with end-stage renal disease (ESRD). We prospectively enrolled 46 elderly patients...
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Long-term Prognosis of Anti-Neutrophil Cytoplasmic Antibody-Negative Renal Vasculitis: Cohort Study in Korea

Lee SW, Yu MY, Baek SH, Ahn SY, Kim S, Na KY, Chae DW, Chin HJ

Few studies have reported on the long-term prognosis of anti-neutrophil cytoplasmic antibody (ANCA)-negative renal vasculitis. Between April 2003 and December 2013, 48 patients were diagnosed with renal vasculitis. Their ANCA...
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A quantitative approach for cardiovascular safety evaluation of a generic drug

Son M, Kim Y, Chae DW, Park K

In generic drug development, comparative pharmacokinetic (PK) studies are conducted to assess equivalence in pharmacokinetics and safety profiles between test and reference formulations. However, there is no established quantitative approach...
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Predictive Value of Echocardiographic Parameters for Clinical Events in Patients Starting Hemodialysis

Han SS, Cho GY, Park YS, Baek SH, Ahn SY, Kim S, Chin HJ, Chae DW, Na KY

Echocardiographic parameters can predict cardiovascular events in several clinical settings. However, which echocardiographic parameter is most predictive of each cardiovascular or non-cardiovascular event in patients starting hemodialysis remains unresolved. Echocardiography...
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Effect of Bilirubin on Triglyceride Synthesis in Streptozotocin-Induced Diabetic Nephropathy

Xu J, Lee ES, Baek SH, Ahn SY, Kim S, Na KY, Chae DW, Chin HJ

We aimed to elucidate the effect of bilirubin on dyslipidemia and nephropathy in a diabetes mellitus (DM) type I animal model. Sprague-Dawley rats were separated into control, DM, and bilirubin-treated...
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Bilirubin Activates Transcription of HIF-1alpha in Human Proximal Tubular Cells Cultured in the Physiologic Oxygen Content

Kim SG, Ahn SY, Lee ES, Kim S, Na KY, Chae DW, Chin HJ

The expression of hypoxia-inducible factor (HIF) is influenced by reactive oxygen species (ROS). Effect of bilirubin on HIF-1 expression in proximal tubular cells was investigated under physiological oxygen concentration, which...
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Cobalt Chloride Attenuates Oxidative Stress and Inflammation through NF-kappaB Inhibition in Human Renal Proximal Tubular Epithelial Cells

Oh SW, Lee YM, Kim S, Chin HJ, Chae DW, Na KY

We evaluated the effect of cobalt chloride (CoCl2) on TNF-alpha and IFN-gamma-induced-inflammation and reactive oxygen species (ROS) in renal tubular epithelial cells (HK-2 cells). We treated HK-2 cells with CoCl2...
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New classification of membranoproliferative glomerulonephritis: a good start but a long way to go

Chae DW

No abstract available.
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Correction of Anemia with Continuous Erythropoietin Receptor Activator in Korean Patients on Long-Term Hemodialysis

Oh J, Joo KW, Chin HJ, Chae DW, Kim SG, Kim SJ, Chung W, Kim S, Huh W, Oh HY, Choi BS, Yang CW, Kim S

Continuous erythropoietin receptor activator (CERA) is an erythropoietin with a long-half life. This study investigated the efficacy of CERA for correcting anemia in Korean patients on dialysis. Patients (> or...
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Small Increases in Plasma Sodium Are Associated with Higher Risk of Mortality in a Healthy Population

Oh SW, Baek SH, An JN, Goo HS, Kim S, Na KY, Chae DW, Kim S, Chin HJ

Elevated blood pressure (BP) is the most common cause of cardiovascular disease. Salt intake has a strong influence on BP, and plasma sodium (pNa) is increased with progressive increases in...
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Evaluation of Renal Oxygenation in Normal Korean Volunteers Using 3.0 T Blood Oxygen Level-Dependent MRI

Hwang SI, Lee HJ, Chin HJ, Chae DW, Na KY

PURPOSE: Renal blood oxygen level-dependent (BOLD) MRI has been used in the evaluation of renal oxygenation. We tried to provide the normal R2* value of the human kidney with 3.0...
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