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Biomarkers and diagnostic tools for lung cancer

Lee SH, Lee EH, Kim EY, Choi YJ, Cha YJ, Chang YS

Lung cancer is the leading cause of cancer-related deaths in developing to advanced countries worldwide. The incidence rate of lung cancer in Korea has been increasing steadily since 1997. Statistics...
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A retrospective cytohistological correlation of fine-needle aspiration cytology with classification by the Milan System for Reporting Salivary Gland Cytopathology

Park JH, Cha YJ, Seo JY, Lim JY, Hong SW

Background: Before publication of the new classification system named the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) in 2018, there was no standard classification for salivary gland lesions obtained...
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Expression and Role of Epithelial Membrane Proteins in Tumorigenesis of Hormone Receptor-Positive Breast Cancer

Cha YJ, Koo JS

Purpose: Studies on the expression of epithelial membrane proteins (EMPs) in breast cancer have been rare and limited. In the present study, we aimed to evaluate the expression of EMP1,...
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Suggestions for Specialization and Enhancing Capacity in National Blood Services

Kim HO, Cha YJ, Park Q, Choi EK, Lim YA, Seo DH, Hwang YS

Blood is an essential medical resource for treating diseases and trauma of people, but a limited biological resource for which no artificial production is possible. Therefore, systematic and rational management...
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Types, Production and Validation of Reference Materials for Viral Genetic Testing

Cho EJ, Lee EJ, Cha Y, Lee N, Hong KH, Huh HJ, Cha YJ, Kim HS

Molecular diagnostic techniques are used for the diagnosis and monitoring of viral infections. The performance of the in vitro diagnostic assays is important for an accurate and prompt diagnosis. Positive...
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Adjunctive markers for classification and diagnosis of central nervous system tumors: results of a multi-center neuropathological survey in Korea

Cha YJ, Kim SH, Kim NR, The Neuropathology Study Group of the Korean Society of Pathologists

Background: The revised 4th 2016 World Health Organization (WHO) classification of tumors of the central nervous system (CNS) classification has adopted integrated diagnosis encompassing the histology and molecular features of...
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Correlation of PD-L1 Expression Tested by 22C3 and SP263 in Non-Small Cell Lung Cancer and Its Prognostic Effect on EGFR Mutation–Positive Lung Adenocarcinoma

Kim T, Cha YJ, Chang YS

BACKGROUND: Programmed death-ligand 1 (PD-L1) expression is tested by immunohistochemistry (IHC)—22C3, SP263, and SP142. The aim of this study is to evaluate the correlation among the three methods of PD-L1...
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A Case of Solitary Fibrous Tumor of Hard Palate

Shin SH, Hong MP, Cha YJ, Lim JY

Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm first described and often encountered in the pleura. It has also been documented in a variety of extrapleural sites including the...
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Chordomas: Histopathological Study in View of Anatomical Location

Cha YJ, Suh YL

BACKGROUND: Chordomas are aggressive bone tumors that have a predilection for the axial skeleton including the skull base and spinal/sacral bones. However, the histopathological and clinical differences between skull base...
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A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea

Seo JY, Park JH, Pyo JY, Cha YJ, Jung CK, Song DE, Kwak JJ, Park SY, Na HY, Kim JH, Seok JY, Kim HS, Hong SW

BACKGROUND: In the present multi-institutional study, the prevalence and clinicopathologic characteristics of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) were evaluated among Korean patients who underwent thyroidectomy for...
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Long-Term Stability of HBV, HCV, and HIV-1 National Reference Standards for in vitro Diagnostic Medical Devices Intended to Be Used for the Nucleic Acid Amplification Test

Choi KY, Youn KW, Cha YJ, Min HK, Kim J

BACKGROUND: National reference standards are essential to the quality assessment and regulatory approval of in vitro diagnostic medical devices. However, the long-term stability of national reference standards has not been...
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The Effect of Mental Rotation on Surgical Pathological Diagnosis

Park H, Kim HS, Cha YJ, Choi J, Minn Y, Kim KS, Kim SH

PURPOSE: Pathological diagnosis involves very delicate and complex consequent processing that is conducted by a pathologist. The recognition of false patterns might be an important cause of misdiagnosis in the...
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The Clinical Utilization of Radiation Therapy in Korea between 2011 and 2015

Seo YS, Kim MS, Kang JK, Jang WI, Kim HJ, Cho CK, Yoo HJ, Paik EK, Cha YJ, Yoon JS

PURPOSE: The purpose of this study was to estimate the clinical utilization of radiation therapy (RT) in Korea between 2011 and 2015. MATERIALS AND METHODS: We analyzed the claims data from...
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Incidental Breast Lesions on Chest CT: Clinical Significance and Differential Features Requiring Referral

Choi YJ, Kim TH, Cha YJ, Son EJ, Gweon HM, Park CH

PURPOSE: To evaluate the CT features of incidental breast lesions on chest CT and to suggest useful criteria for referral to a specialized breast unit. MATERIALS AND METHODS: Between May 2009...
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A Rare Case of Aggressive Melanotic Schwannoma Occurred in Spinal Nerve of a 59-Year-Old Male

Choi SE, Cha YJ, Kim J, Cha H, Seo J, Kuh SU, Kim SJ, Kim SH

Melanotic schwannoma (MS) is a rare variant of nerve sheath neoplasm that shows ultrastructural and immunophenotypical features of Schwann cells but also has cytoplasmic melanosomes and is reactive for melanocytic...
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Role of the ABCB1 Drug Transporter Polymorphisms in the Pharmacokinetics of Oseltamivir in Humans: a Preliminary Report

Cha YJ, Ghim JL

Oseltamivir is a substrate of P-glycoprotein, an efflux drug transporter encoded by ABCB1. The objective of this study was to assess the role of ABCB1 (c.1236C>T, c.2677G>T/A, and c.3435C>T) polymorphisms...
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Stereotactic body radiation therapy for liver oligo-recurrence and oligo-progression from various tumors

Cha YJ, Kim MS, Jang WI, Seo YS, Cho CK, Yoo HJ, Paik EK

PURPOSE: To evaluate the outcomes of stereotactic body radiation therapy (SBRT) for patients with liver oligo-recurrence and oligo-progression from various primary tumors. MATERIALS AND METHODS: Between 2002 and 2013, 72 patients...
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The Reliability and Validity of the Korean Version of Behavioral Activation for Depression Scale

Oh JH, Hwang NR, Cha YJ, Lee EB, Choi KH, Seo HJ

OBJECTIVES: The Behavioral Activation of Depression Scale (BADS) has been reported to be a valid tool for assessing the different behavioral aspects of depression, such as activation, rumination or avoidance,...
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Keratinization of Lung Squamous Cell Carcinoma Is Associated with Poor Clinical Outcome

Park HJ, Cha YJ, Kim SH, Kim A, Kim EY, Chang YS

BACKGROUND: Although the World Health Organization (WHO) classification of lung squamous cell carcinoma (SCC) was revised in 2015, its clinical implications for lung SCC subsets remain unclear. We investigated whether...
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Proposal of Modified HIL-indices for Determining Hemolysis, Icterus and Lipemia Interference on the Beckman Coulter AU5800 Automated Platform

Lim YK, Cha YJ

BACKGROUND: The amount of interference due to hemolysis, bilirubin, and lipemia can be measured on the AU5800 autoanalyzer (Beckman Coulter, USA) by spectrophotometry. This is reported as semi-quantitative indices, specifically...
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