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Validation of “sasLM,” an R package for linear models with type III sum of squares

Sunwoo J, Kim H, Choi D, Bae KS

The general linear model (GLM) describes the dependent variable as a linear combination of independent variables and an error term. The GLM procedure of SAS® and the “car” package in...
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Bioequivalence data analysis

Park G, Kim H, Bae KS

SAS® is commonly used for bioequivalence (BE) data analysis. R is a free and open software for general purpose data analysis, and is less frequently used than SAS® for BE...
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Analytical solution of linear multi-compartment models with non-zero initial condition and its implementation with R

D'Argenio , Bae KS

The analytical solution for multi-compartment models with a non-zero initial condition is complex because of the inter-compartmental transfer. An elegant solution and its implementation in the ‘wnl' R package can...
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Experiences of the Emergency Department at the Pyeongchang Polyclinic During the 2018 PyeongChang Winter Olympic Games

Kim K, Jang JY, Moon G, Shim H, Jung PY, Kim S, Choi YU, Bae KS

PURPOSE: The 2018 PyeongChang Winter Olympic Games involved 2925 elite athletes, and providing proper health care services for these elite athletes was a critical priority. We established an emergency department...
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Current status of the Korean acute care surgery system for non-traumatic abdominal emergency surgery: a single-regional trauma center study

Jang JY, Shim H, Kim JH, Hong SK, Bae KS

Abdominal sepsis is mainly caused by intra-abdominal or retroperitoneal infection; therefore, early detection of the source of infection and adequate, prompt treatment are the most important contributors to patient outcomes....
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LAMMER Kinase Lkh1 Is an Upstream Regulator of Prk1-Mediated Non-Sexual Flocculation in Fission Yeast

Park YD, Kwon SJ, Bae KS, Park HM

The cation-dependent galactose-specific flocculation activity of the Schizosaccharomyces pombe null mutant of lkh1⁺, the gene encoding LAMMER kinase homolog, has previously been reported by our group. Here, we show that...
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Erratum: Development of R packages: ‘NonCompart’ and ‘ncar’ for noncompartmental analysis (NCA)

Kim H, Han S, Cho YS, Yoon SK, Bae KS

There are some errors in the published article. The authors would like to make corrections in the original version of the article.
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Therapeutic Efficacy of Lamivudine in Children and Adolescents with Chronic Hepatitis B

Choi Y, Bae KS, Kim KH, Koh DK, Kim JH

PURPOSE: This prospective study aimed to investigate the therapeutic efficacy of lamivudine in children with chronic hepatitis B virus (HBV) infection. METHODS: During July 2003 through October 2015, children with chronic...
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Erratum: R-based reproduction of the estimation process hidden behind NONMEM Part 2: First-order conditional estimation

Bae KS, Yim DS

The equations on page 162 should be corrected.
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Trauma-Induced Retroperitoneal Paraganglioma Rupture Which Was Misunderstood as a Massive Retroperitoneal Hemorrhage

Shim H, Jang JY, Kim YJ, Lim JS, Bae KS

No abstract available.
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Risk Factors Associated with Mortality of Patients with Pelvic Fractures and Hemodynamic Instability in a Korean Trauma Center

Kim MH, Shim H, Bae KS, Ryu H, Jang JY

PURPOSE: The aim of this study is to evaluate treatment outcomes and mortality risks associated with hemodynamic instability caused by severe pelvic fracture in a regional trauma center. METHODS: The medical...
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Development of R packages: ‘NonCompart’ and ‘ncar’ for noncompartmental analysis (NCA)

Kim H, Han S, Cho YS, Yoon SK, Bae KS

Noncompartmental analysis (NCA) is a primary analytical approach for pharmacokinetic studies, and its parameters act as decision criteria in bioequivalent studies. Currently, NCA is usually carried out by commercial softwares...
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Pharmacokinetic Equivalence of the High Dose Strength Fixed-Dose Combination Tablet of Gemigliptin/Metformin Sustained Release (SR) and Individual Component Gemigliptin and Metformin XR Tablets in Healthy Subjects

Cho YS, Lee SH, Lim HS, Bae KS

BACKGROUND: In type 2 diabetes mellitus therapy, fixed-dose combination (FDC) can offer not only benefits in glucose control via the combined use of agents, but also increase patient compliance. The...
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Characteristics of Pediatric and Adolescent Trauma-Database Review of Single Level Trauma Center in Gangwon Province

Lee TH, Jung PY, Kwon HY, Shim H, Jang JY, Bae KS, Kim S

PURPOSE: Although trauma is the most common cause of death under age 18, Korean national pediatric trauma data has lack of clinical data. This study is to prepare manpower resources,...
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Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications

Han S, Cho YS, Yoon SK, Kim H, Bae KS

Caffeine is a naturally-occurring central nervous system stimulant found in plant constituents including coffee, cocoa beans, and tea leaves. Consumption of caffeine through imbibing caffeinated drinks is rapidly growing among...
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Combined Effect of Initial and Longitudinal Increases in γ-Glutamyltransferase on Incident Metabolic Syndrome: ARIRANG Study

Yadav D, Lee MY, Kim JY, Ryu H, Huh JH, Bae KS, Ahn SV, Chung CH, Park JT, Koh SB

PURPOSE: Although γ-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome (MS), prospective data on baseline and longitudinal changes in GGT levels and incident cases of MS are...
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Bioequivalence data analysis for the case of separate hospitalization

Bae KS, Kang SH

A bioequivalence study is usually conducted with the same-day drug administration. However, hospitalization is occasionally separated for logistical, operational, or other reasons. Recently, there was a case of separate hospitalization...
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General Principles in Hemodynamic Monitoring

Kwon HY, Jang JY, Bae KS, Shim H

Hemodynamic monitoring continuously checks hemodynamic variables for problems so that the clinician can treat them when a patient's vital signs are unstable. There are many different monitoring systems, and many...
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Forensic science meets clinical pharmacology: pharmacokinetic model based estimation of alcohol concentration of a defendant as requested by a local prosecutor's office

Lim HS, Soung JH, Bae KS

Drunk driving is a serious social problem. We estimated the blood alcohol concentration of a defendant on the request of local prosecutor's office in Korea. Based on the defendant's history,...
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Community-acquired Escherichia coli Enteritis in Korean Children: The Clinical Application of a Stool Polymerase Chain Reaction Assay

Kim Y, Kim HJ, Lim S, Bae KS, Han SB, Jeong DC, Kang JH, Shin GJ, Lee GD, Park YJ

BACKGROUND: Although Escherichia coli is a common cause of bacterial enteritis in Korea, reports on community-acquired E. coli enteritis in Korean children are scarce. This study aimed to determine the...
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