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Participation of D-serine and NR2 subunits in EphA4-mediated trigeminal neuropathic pain

Kim MD, Kim MJ, Son JY, Kim YM, Ju JS, Ahn DK

The present study investigated the participation of D-serine and NR2 in antinociception produced by blockade of central erythropoietin-producing hepatocellular carcinoma (Eph) A4 (EphA4) signaling in rats with trigeminal neuropathic pain....
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Clinical Effects and Complications of Pedicle Screw Augmentation with Bone Cement: Comparison of Fenestrated Screw Augmentation and Vertebroplasty Augmentation

Kim JH, Ahn DK, Shin WS, Kim MJ, Lee HY, Go YR

Background: Pedicle screw augmentation with bone cement has been experimentally demonstrated to increase the pullout strength. However, the mechanisms of screw loosening are complicated and interacting. Although vertebroplasty augmentation and...
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Vertebral Body Anterior Translation, a Novel Technique for Delayed Myelopathy Due to Osteoporotic Spine Fractures

Lee JS, Ahn DK, Shin WS, Cho KJ, Ko YR, Whang IC

Background: Osteoporotic vertebral compression fractures (OVCFs) are often associated with delayed myelopathy. Surgical treatment of delayed myelopathy following an OVCF comprises spinal canal decompression and stable fixation of the vertebral...
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Influence of Epidural Steroid Injection on Adrenal Function

Shin WS, Ahn DK, Kim MJ, Cho KJ, Go YR

BACKGROUND: Spinal diseases are self-limited or non-progressive in many cases. Epidural steroid injection (ESI) is a common nonsurgical treatment option for spinal pain. Despite concerns about complications of repeated steroid...
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The Evidence for Nonoperative Treatment of Lumbar Spinal Diseases

Kim HS, Ahn DK, Seo HY, Kim CS, Kim MJ

STUDY DESIGN: Review article. OBJECTIVES: To assess the evidence for nonoperative treatment of various degenerative spinal degenerative diseases. SUMMARY OF LITERATURE REVIEW: No study has yet evaluated the evidence for preoperative nonoperative...
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Participation of Opioid Pathway in the Central Antinociceptive Effects of Eugenol

Kang SH, Kang SW, Kim JH, Kim HY, Ryu HS, Bae SY, Oh JA, Lee JH, Hyun JH, Ahn DK

The aim of the present study was to evaluate the central antinociceptive effects of eugenol after intraperitoneal administration. Experiments were carried out using male Sprague-Dawley rats. Subcutaneous injection of 5%...
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Spinal Subarachnoid Hematoma after Spinal Anesthesia: A Case Report

Lee JS, Ahn DK, Shin WS, Yoo IS, Lee HY

STUDY DESIGN: Case report. OBJECTIVES: We report a case of spinal subarachnoid hematoma that developed after spinal anesthesia in a female patient who had no risk factors. SUMMARY OF LITERATURE REVIEW: Few...
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Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice

Jang SH, Park SJ, Lee CJ, Ahn DK, Han SK

Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus...
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The Influence of Antiplatelet Drug Medication on Spine Surgery

Shin WS, Ahn DK, Lee JS, Yoo IS, Lee HY

BACKGROUND: The incidence of cardiovascular and neurovascular diseases has been increasing with the aging of the population, and antiplatelet drugs (APDs) are more frequently used than in the past. With...
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Prognostic Factors of Neurological Complications in Spinal Surgeries

Shin WS, Ahn DK, Lee JS, Koo KH, Yoo IS

STUDY DESIGN: Retrospective study. PURPOSE: To determine prognostic factors of neurological complications (NCs) of posterior thoracolumbar surgeries. OVERVIEW OF LITERATURE: There have been few reports on the prognosis of NCs according to...
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Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats

Yoon JH, Son JY, Kim MJ, Kang SH, Ju JS, Bae YC, Ahn DK

The aim of the present study was to examine the effects of preemptive analgesia on the development of trigeminal neuropathic pain. For this purpose, mechanical allodynia was evaluated in male...
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Neurological Complications of Posterior Spinal Surgery: Incidence and Clinical Features

Ahn DK, Lee JS, Shin WS, Yi SM, Koo KH

STUDY DESIGN: Retrospective study. OBJECTIVES: To identify clinical features and risk factors helpful for the prevention and early diagnosis of neurological complications. OVERVIEW OF LITERATURE: Previous studies have investigated postoperative complications only...
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Blockade of Trigeminal Glutamate Recycling Produces Anti-allodynic Effects in Rats with Inflammatory and Neuropathic Pain

Yang KY, Lee MK, Park MK, Son JY, Ju JS, Ahn DK

The present study investigated the role of spinal glutamate recycling in the development of orofacial inflammatory pain or trigeminal neuropathic pain. Experiments were carried out on male Sprague-Dawley rats weighing...
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Analgesic Effects of Antiosteoporotic Drugs

Ahn DK, Shin WS, Kim GW

STUDY DESIGN: Literature review. OBJECTIVES: To propose possible mechanisms of osteoporotic back pain and its management with antiosteoporotic drugs. SUMMARY OF LITERATURE REVIEW: No general conclusion has yet been reached regarding whether...
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Peripheral Cellular Mechanisms of Artemin-induced Thermal Hyperalgesia in Rats

Kim HJ, Yang KY, Lee MK, Park MK, Son JY, Ju JS, Ahn DK

In the present study, we investigated the role of peripheral ionotropic receptors in artemin-induced thermal hyperalgesia in the orofacial area. Male Sprague-Dawley rats weighting 230 to 280 g were used...
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Postoperative Spinal Epidural Hematoma: The Danger Caused by the Misuse of Thrombin-Containing Local Hemostatics

Ahn DK, Shin WS, Kim GW, Koo KH

STUDY DESIGN: Retrospective case-control study. PURPOSE: To examine the hypothesis that the misuse of thrombin-containing local hemostatics (TCLH) increases the risk of postoperative spinal epidural hematoma (POSEH). OVERVIEW OF LITERATURE: Many studies...
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Participation of central GABAA receptors in the trigeminal processing of mechanical allodynia in rats

Kim MJ, Park YH, Yang KY, Ju JS, Bae YC, Han SK, Ahn DK

Here we investigated the central processing mechanisms of mechanical allodynia and found a direct excitatory link with low-threshold input to nociceptive neurons. Experiments were performed on male Sprague-Dawley rats weighing...
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Participation of IL-1β in temporomandibular nociception in rats with CFA-induced inflammation

Ju JS, Choi SH, Kim HJ, Son JY, Ahn DK

The aim of the present study was to develop an animal model for evaluation of temporomandibular (TMJ) nociception under TMJ inflammation. We also investigated the participation of IL-1β in inflammation-induced...
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Can We Prevent a Postoperative Spinal Epidural Hematoma by Using Larger Diameter Suction Drains?

Ahn DK, Kim JH, Chang BK, Lee JI

BACKGROUND: Epidural hematoma is a rare but serious complication. According to previous studies, it is not prevented by suction drains. This study evaluated the following alternative hypothesis: the larger the...
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Silicone Implant-Based Paranasal Augmentation for Mild Midface Concavity

Kim JH, Jung MS, Lee BH, Jeong HS, Suh IS, Ahn DK

BACKGROUND: Midface concavity is a relatively common facial feature in East Asian populations. Paranasal augmentation is becoming an increasingly popular procedure for patients with mild concavity and normal occlusion. In...
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