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Estrogen Replacement Reduces Hearing Threshold Shifts and Cochlear Hair Cell Loss After Acoustic Overexposure in Ovariectomized Rats

Kim MT, Lee JH, Carpena NT, Lee MY, Chung PS, Jung JY

Objectives. The relationship of estrogen (the primary female sex hormone) with hearing function has been studied in both humans and animals. However, whether estrogen levels affect hearing remains uncertain. Therefore,...
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Ovariectomy, but not orchiectomy, exacerbates metabolic syndrome after maternal high-fructose intake in adult offspring

Kim M, Kim I

High fructose diet is associated with the global metabolic syndrome (MtS) pandemic. MtS develops in early life, depending on prenatal and postnatal nutritional status. We hypothesized that ovariectomy increases the...
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Three-dimensional microstructures of the intracortical canals in the animal model of osteoporosis

Lee SH, Kim JN, Shin KJ, Koh KS, Song WC

Osteoporosis is a major disease in aged women, increasing the risk for fractures accompanied by changes in the microarchitecture. The aim of this study was to investigate the three-dimensional (3D)...
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Interleukin-10-Producing B Cells Help Suppress Ovariectomy-Mediated Osteoporosis

Wang Y, Zhang W, Lim SM, Xu L, Jin JO

Osteoporosis is prevalent in elderly women and it may cause dental implant failure. In particular, estrogen deficiency in postmenopausal women leads to higher rates of osteoporosis prevalence. Immune cell-mediated effects...
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Effects of Di(2-ethylhexyl)phthalate on Bone Metabolism in Ovariectomized Mice

Choi JI, Cho HH

BACKGROUND: The molecular pathways of how endocrine disruptors affect bone mineral density (BMD) and bone remodeling are still unclear. The purpose of this experimental study is to determine the effects...
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Spontaneous pneumothorax in two dogs undergoing combined laparoscopic ovariectomy and total laparoscopic gastropexy

Bendinelli C, Leonardi F, Properzi R

Two dogs underwent a combined laparoscopic ovariectomy and total laparoscopic gastropexy. The intra-abdominal pressure and pulmonary compliance decreased, but the peak airway pressure increased at 20 min after the start...
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SPA0355 prevents ovariectomy-induced bone loss in mice

Kim SH, Zhang Z, Moon YJ, Park IW, Cho YG, Jeon R, Park BH

Estrogen withdrawal in post-menopausal women leads to overactivation of osteoclasts, which contributes to the development of osteoporosis. Inflammatory cytokines are known as one of mechanisms of osteoclast activation after estrogen...
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High Estradiol Differentially Affects the Expression of the Glucose Transporter Type 4 in Pelvic Floor Muscles of Rats

de los Ángeles Carrasco-Ruiz , Hernández-Aragón LG, Chávez-Ríos JR, Rodríguez-Antolín J, Pacheco P, Martínez-Gómez M, Cuevas-Romero E, Castelán

PURPOSE: To characterize the relationship between serum estradiol levels and the expression of glucose transporter type 4 (Glut4) in the pubococcygeus and iliococcygeus muscles in female rats. METHODS: The muscles were...
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Effect of isoflavone-enriched whole soy milk powder supplementation on bone metabolism in ovariectomized mice

Kim SM, Lee HS, Jung JI, Lim SM, Lim JH, Ha WH, Jeon CL, Lee JY, Kim EJ

BACKGROUND/OBJECTIVE: There is intense interest in soy isoflavone as a hormone replacement therapy for the prevention of postmenopausal osteoporosis. A new kind of isoflavone-enriched whole soy milk powder (I-WSM) containing...
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An Ovariectomy-Induced Rabbit Osteoporotic Model: A New Perspective

Wanderman , Mallet C, Giambini H, Bao N, Zhao C, An KN, Freedman B, Nassr A

STUDY DESIGN: Experimental Animal Model. PURPOSE: The aim of our study was to validate a pure bilateral ovariectomy (OVX) female New Zealand white rabbit model of postmenopausal osteoporosis utilizing animal-sparing in...
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Flavonoids Fraction of Mespilus Germanica Alleviates Insulin Resistance in Metabolic Syndrome Model of Ovariectomized Rats via Reduction in Tumor Necrosis Factor-α

Kouhestani S, Zare S, Babaei P

OBJECTIVES: The rate of metabolic syndrome (MetS) in women diagnosed as they age is one of the main concerns of health cares. Recently new strategies used to prevent progressions of...
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The effect of Puerariae Radix on ovariectomy-induced bone loss in C3H/HeN mice

Ahn B, Lee S, Kang S, Moon C, Kim JC, Jang JS, Kim SH

Osteoporosis is a major worldwide public health problem that poses a great economic burden to society. Puerariae Radix, the dried root of Pueraria lobata (Wild.) Ohwi, has been widely used...
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Ovarian teratoma removed by laparoscopic ovariectomy in a dog

Tavares IT, Barreno RR, Sales-Luís JP, Vaudano CG

An elective laparoscopic ovariectomy on a healthy dog revealed a cystic structure in the left ovary. The surgical procedure was successful. Histopathological examination showed the presence of a teratoma adjacent...
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Adipogenic and Lipolytic Effects of Ascorbic Acid in Ovariectomized Rats

Kim B, Choi KM, Yim HS, Park HT, Yim JH, Lee MG

PURPOSE: Ascorbic acid has been reported to have an adipogenic effect on 3T3-L1 preadipocytes, while evidence also suggests that ascorbic acid reduces body weight in humans. In this study, we...
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Antiosteoporotic activity of Salvadora persica sticks extract in an estrogen deficient model of osteoporosis

Fouda AM, Youssef AR

OBJECTIVES: The effect of Salvadora persica sticks on prevention of tooth decay is well established, but the effect of S. persica stick extract (SPE) on the prevention/treatment of osteoporosis has...
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Protective effect of Rhus verniciflua Stokes extract in an experimental model of post-menopausal osteoporosis

Jeong JH, An JH, Yang H, Kim DK, Lee NS, Jeong YG, Na CS, Na DS, Dong MS, Han SY

Post-menopausal osteoporosis (PMO) is a major global human health concern. Owing to the need for therapeutic drugs without side effects, natural extracts containing various polyphenolic compounds that may exert estrogenic...
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Safety of ovarian preservation in premenopausal women with stage I uterine sarcoma

Nasioudis , Chapman-Davis E, Frey M, Holcomb K

OBJECTIVE: To evaluate the oncologic safety of ovarian preservation (OP) in premenopausal women diagnosed with the International Federation of Gynecology and Obstetrics (FIGO) stage I uterine sarcoma. METHODS: The National Cancer...
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Effect of oral guava leaf extract administration on antioxidant and vasculoprotective activity in ovariectomized rats

Ko EJ, Liu Y, Kim HS

PURPOSE: The aim of this study was to assess the effects of guava leaf extract (GLE) supplementation on antioxidant enzyme activity and expression of endothelial nitric oxide synthase (eNOS) mRNA...
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The Therapeutic Effects of Combination Therapy with Curcumin and Alendronate on Spine Fusion Surgery in the Ovariectomized Rats

Cho DC, Ryu K, Kim KT, Sung JK

OBJECTIVE: The purpose of this study was to evaluate the therapeutic effects of combination therapy with curcumin and alendronate on spine fusion surgery in ovariectomized rats. METHODS: Thirty-two female Sprague-Dawley rats...
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Difference in Spinal Fusion Process in Osteopenic and Nonosteopenic Living Rat Models Using Serial Microcomputed Tomography

Park SB, Yang HJ, Kim CH, Chung CK

OBJECTIVE: To identify and investigate differences in spinal fusion between the normal and osteopenic spine in a rat model. METHODS: Female Sprague Dawley rats underwent either an ovariectomy (OVX) or sham...
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