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Fragility Fractures of the Pelvis and Sacrum

Lee SW, Kim JY

The incidence of fragility fractures of the pelvis (FFP) has increased significantly due to the aging popu-lation and improved diagnostic modalities. The evaluation and treatment of these patients differ from...
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Positive Effects of Biologics on Osteoporosis in Rheumatoid Arthritis

Kim Y, Kim GT

Osteoporosis is a systemic skeletal disorder that causes vulnerability of bones to fracture owing to reduction in bone density and deterioration of the bone tissue microstructure. The prevalence of osteoporosis...
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Trabecular Bone Score as a Risk Factor of Major Osteoporotic Fracture in Postmenopausal Women: The First Study in Thailand

Therdyothin A, Amphansap T

Objectives: To compare the trabecular bone score (TBS) between Thai postmenopausal women with and without major osteoporotic fracture, and to determine whether TBS is associated with fracture risk. Methods: All postmenopausal...
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Identification of novel susceptibility genes associated with bone density and osteoporosis in Korean women

Kim BY, Kim DW, Park E, Kim J, Lee CG, Jin HS, Jeong SY

Purpose: Osteoporosis is a common calcium and metabolic skeletal disease which is characterized by decreased bone mass, microarchitectural deterioration of bone tissue and impaired bone strength, thereby leading to enhanced...
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Management of Osteoporotic Vertebral Fracture: Review Update 2022

Jang HD, Kim EH, Lee JC, Choi SW, Kim HS, Cha JS, Shin BJ

A vertebral fracture is the most common type of osteoporotic fracture. Osteoporotic vertebral fractures (OVFs) cause a variety of morbidities and deaths. There are currently few “gold standard treatments” outlined...
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Molecular mechanisms of hederagenin in bone formation

Seo HJ, Kwun IS, Kwon J, Sim Y, Cho YE

Purpose: Osteoporosis is characterized by structural deterioration of the bone tissue because of the loss of osteoblastic activity or the increase in osteoclastic activity, resulting in bone fragility and an...
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Up-to-Date Knowledge on Osteoporosis Treatment Selection in Postmenopausal Women

Jeong HG, Kim MK, Lim HJ, Kim SK

The concept of a super-aged society has led to a steady increase in the average lifespan and hence, interest in a healthy life has increased. Aging is a major risk...
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A Vitronectin-Derived Peptide Restores Ovariectomy-Induced Bone Loss by Dual Regulation of Bone Remodeling

Kang HK, Park CY, Jung SY, Jo SB, Min BM

BACKGROUND: Bone remodeling is tightly regulated through bone resorption and bone formation; imbalances in bone remodeling can cause various pathological conditions such as osteoporosis. Antiresorptive agents commonly used for treating...
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Preliminary Screening Method for Low Bone Mineral Density Using a Self-Reported Questionnaire among Peri- and Postmenopausal Women

Yano Y, Iwata E, Sada T, Ueno Y, Hyakuda Y, Kawasaki S, Okuda A, Shigematsu H, Uematsu K, Yajima H, Tanaka Y

Study Design: Retrospective cohort study. Purpose: We propose a method for screening for low bone mineral density (BMD) among perimenopausal and postmenopausal women using a self-reported questionnaire. Overview of Literature: Osteoporosis is...
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Vitamin D intake and bone mineral density in Korean adults: analysis of the 2009–2011 Korea National Health and Nutrition Examination Survey

You H, Shin HR, Song S, Ly SY

BACKGROUND/OBJECTIVES: The prevalence of vitamin D deficiency in Koreans is quite high; however, until recently, Korean National Health and Nutrition Survey (KNHANES) had not analyzed the vitamin D intake among...
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The Association of Coronary Artery Calcium Score and Osteoporosis in Postmenopausal Women: A Cross-Sectional Study

Asadi M, Razi F, Fahimfar N, Shirani S, Behzad G, Salari P

Background: The association between osteoporosis, a common metabolic bone disorder, and atherosclerosis has been reported in different studies. In this study, we aimed to investigate the association between the coronary...
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Effect of Lactobacillus Fermentum as a Probiotic Agent on Bone Health in Postmenopausal Women

Han HS, Kim JG, Choi YH, Lee KM, Kwon TH, Kim SH

Background: Probiotics are live microorganisms that confer health benefits on the host. Many animal studies have shown that among the probiotics, lactobacilli exert favorable effects on bone metabolism. Herein, we...
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The Role of Bisphosphonates Prior to Denosumab Treatment on Rebound Fractures: A Mini Review

Inojosa AC, Mendes L, Bandeira L, Bandeira F

Denosumab is a potent anti-resorptive medication used to treat patients at high risk for osteoporosis; however, its beneficial effects on the skeletal system are quickly reversed after discontinuation. In contrast,...
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Position Statement: Vitamin D Intake to Prevent Osteoporosis and Fracture in Adults

Han A, Park Y, Lee YK, Park SY, Park CY

Adequate vitamin D status is essential for bone health. New randomized controlled trials investigating the effect of vitamin D supplementation on bone health have recently been published. This position statement...
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Benefits of a Demineralized Bone Matrix in Osteoporotic Intertrochanteric Femoral Fracture Patients

Kim SJ, Cho HM, Jung MC

Purpose: Osteoporosis causes various fixation failures in patients with intertrochanteric fractures. This study aimed to investigate the effect of a demineralized bone matrix (DBM) for cancellous or cortical bone defects...
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1,3-Dibenzyl-5-Fluorouracil Prevents Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Differentiation

Jeon H, Yu J, Hwang JM, Park HW, Yu J, Lee ZW, Kim T, Rho J

Osteoclasts (OCs) are clinically important cells that resorb bone matrix. Accelerated bone destruction by OCs is closely linked to the development of metabolic bone diseases. In this study, we screened...
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Acute Operative Management of Osteoporotic Vertebral Compression Fractures Is Associated with Decreased Morbidity

Mills ES, Ton AT, Bouz G, Alluri RK, Hah RJ

Study Design: Retrospective national database study design. Purpose: This study was designed to determine whether acute percutaneous vertebral augmentation (PVA) alters morbidity compared with nonoperative management. Overview of Literature: Osteoporotic vertebral compression...
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Pharmacological options for pain control in patients with vertebral fragility fractures

Tanna NK, Ong T

This review considers the evidence base and current knowledge for pharmacological treatment options that are available for pain control in patients with vertebral fractures sustained after a low trauma incident....
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Evaluation of Clinical Outcomes by Therapeutic Dosing Interval of Denosumab (Prolia ® ) and Calcium-Vitamin D Prescriptions

Kim Y, Kim J, Doh H, Jeong YM, Lee J, Lee JY, Lee E

Background: Denosumab (Prolia®) is administered every 6 months for osteoporosis treatment. Co-administration of calcium and vitamin D is required to minimize hypocalcemia risk. We evaluated clinical outcomes based on the...
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Trabecular bone score as an additional therapeutic decision tool in osteoporosis and osteopenia

Therdyothin A, Amphansap T, Apiromyanont K

Objectives: To evaluate the role of trabecular bone score (TBS), in addition to bone mineral density (BMD), and to aid decision making to initiate anti-osteoporotic treatment in postmenopausal women with...
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