- Engineering a High-Affinity PD-1 Peptide for Optimized Immune Cell-Mediated Tumor Therapy
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Chen Y, Huang H, Liu Y, Wang Z, Wang L, Wang Q, Zhang Y, Wang H
- KMID: 2528206
- Cancer Res Treat.
- 2022 Apr;54(2):362-374.
- doi: 10.4143/crt.2021.424
Purpose The purpose of this study was to optimize a peptide (nABP284) that binds to programmed cell death protein 1 (PD-1) by a computer-based protocol in order to increase its affinity.... -
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- Optimization of Cultivation and Extraction Conditions of Pupae-Cordyceps for Cordycepin Production
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Turk A, Kim BS, Ko SM, Yeon SW, Ryu SH, Kim YG, Hwang BY, Lee MK
- KMID: 2521089
- Nat Prod Sci.
- 2021 Sep;27(3):187-192.
- doi: 10.20307/nps.2021.27.3.187
Cordycepin is a characteristic bioactive compound of Cordyceps militaris with various beneficial effects. Cordyceps grows on both grains and insects, and the content of cordycepin varies depending on the cultivation... -
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- Experimental and Mathematical Optimization of a Pooling Test for Detection of SARS-CoV-2 in a Population with Low Viral Load
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Jeong H, Lee J, Cheon S, Sohn KM, Kim J, Kym S, Kim YS
- KMID: 2514839
- Infect Chemother.
- 2021 Mar;53(1):118-127.
- doi: 10.3947/ic.2021.0005
Background: A pooling test is a useful tool for mass screening of coronavirus disease 2019 (COVID-19) in the pandemic era. We aimed to optimize a simple two-step pooling test by... -
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- Polyphenols in peanut shells and their antioxidant activity: optimal extraction conditions and the evaluation of antiobesity effects
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Gam DH, Hong JW, Yeom SH, Kim JW
- KMID: 2513478
- J Nutr Health.
- 2021 Feb;54(1):116-128.
- doi: 10.4163/jnh.2021.54.1.116
Purpose: The extraction conditions for bioactive components from peanut shells, which is a byproduct of peanut processing, were optimized to enhance the total phenolic content (TPC, Y1 ), total flavonoid... -
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- Treatment Planning System for AC Electric Field Therapy Based on Absorbed Energy
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Oh G, Jo Y, Ki Y, Sung H, Yoon M
- KMID: 2510048
- Prog Med Phys.
- 2020 Sep;31(S1):S19.
Purpose: Tumor Treating Electric Fields (TTF) therapy is cancer therapy that passed FDA in the United States. However, TTF therapy doesn’t have the concept of dose commonly used in radiotherapy... -
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- Computed Tomography (CT) Protocols Associated with Cardiac and Bone Single-Photon Emission Computed Tomography/CT (SPECT/CT) in Korea
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Lee EJ, Kim JY, Park JM, Song BI, Choi H, Shim Hk, Park HL, Lee HY, Lee KJ, Yoon JK, Seo S, Kim SM, Park SB, Cho YS, Kim SH
- KMID: 2507686
- Nucl Med Mol Imaging.
- 2020 Jun;54(3):139-146.
- doi: 10.1007/s13139-020-00644-9
Purpose: Single-photon emission computed tomography/computed tomography (SPECT/CT) is an advanced hybrid nuclear medicine technology that generates both functional and anatomical images in a single study. As utilization of SPECT/CT in... -
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- Optimization of Citric Acid Production by Immobilized Cells of Novel Yeast Isolates
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Hesham AEL, Mostafa YS, AlSharqi LEO
- KMID: 2503917
- Mycobiology.
- 2020 Apr;48(2):122-132.
- doi: 10.1080/12298093.2020.1726854
Citric acid is a commercially valuable organic acid widely used in food, pharmaceutical, and beverage industries. In this study, 260 yeast strains were isolated from soil, bread, juices, and fruits... -
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- A novel pectoral muscle segmentation from scanned mammograms using EMO algorithm
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Avuti SK, Bajaj V, Kumar A, Singh GK
- KMID: 2470041
- Biomed Eng Lett.
- 2019 Nov;9(4):481-496.
- doi: 10.1007/s13534-019-00135-7
Mammogram images are majorly used for detecting the breast cancer. The level of positivity of breast cancer is detected after excluding the pectoral muscle from mammogram images. Hence, it is... -
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- Multistaining Optimization for Epstein-Barr Virus–Encoded RNA In Situ Hybridization and Immunohistochemistry of Formalin-Fixed Paraffin-Embedded Tissues Using an Automated Immunostainer
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Ko JN, Jung JK, Park YI, Shin HJ, Huh J, Back S, Kim YJ, Kim JH, Go H
- KMID: 2459580
- J Pathol Transl Med.
- 2019 Sep;53(5):317-326.
- doi: 10.4132/jptm.2019.08.06
BACKGROUND: Single staining is commonly performed for practical pathologic diagnoses. However, this method is limited in its ability to specify cellular morphology and immunophenotype and often requires consumption of limited... -
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- Efficacy of Cardiac Resynchronization Therapy Using Automated Dynamic Optimization and Left Ventricular-only Pacing
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Gwag HB, Park Y, Lee SS, Kim JS, Park KM, On YK, Park SJ
- KMID: 2451549
- J Korean Med Sci.
- 2019 Jul;34(27):e187.
- doi: 10.3346/jkms.2019.34.e187
BACKGROUND: Although device-based optimization has been developed to overcome the limitations of conventional optimization methods in cardiac resynchronization therapy (CRT), few real-world data supports the results of clinical trials that... -
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- Comparison of the Impact of an Optimized Ice Cooling Vest and a Paraffin Cooling Vest on Physiological and Perceptual Strain
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Zare M, Dehghan H, Yazdanirad S, Khoshakhlagh AH
- KMID: 2453005
- Saf Health Work.
- 2019 Jun;10(2):219-223.
- doi: 10.1016/j.shaw.2019.01.004
BACKGROUND: Ice cooling vests can cause tissue damage and have no flexibility. Therefore, these two undesirable properties of ice cooling vest were optimized, and the present study was aimed to... -
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- Optimization of exposure parameters and relationship between subjective and technical image quality in cone-beam computed tomography
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Park HN, Min CK, Kim KA, Koh KJ
- KMID: 2450180
- Imaging Sci Dent.
- 2019 Jun;49(2):139-151.
- doi: 10.5624/isd.2019.49.2.139
PURPOSE: This study was performed to investigate the effect of exposure parameters on image quality obtained using a cone-beam computed tomography (CBCT) scanner and the relationship between physical factors and... -
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- Pharmacokinetic and pharmacodynamic integration of enrofloxacin against Salmonella Enteritidis after administering to broiler chicken by per-oral and intravenous routes
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Kang J, Hossain MA, Park HC, Kim Y, Lee KJ, Park SW
- KMID: 2454017
- J Vet Sci.
- 2019 Mar;20(2):e15.
- doi: 10.4142/jvs.2019.20.e15
It is crucial to optimize the dose of fluoroquinolones to avoid antibiotic resistance and to attain clinical success. We undertook this study to optimize the dose of enrofloxacin against Salmonella... -
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- Antioxidant Activity and Phenolic Content of Different Parts of Lotus and Optimization of Extraction Condition using Response Surface Methodology
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Jang JY, Ahn JH, Jo YH, Hwang BY, Lee MK
- KMID: 2443103
- Nat Prod Sci.
- 2019 Mar;25(1):44-48.
- doi: 10.20307/nps.2019.25.1.44
Nelumbo nucifera Gaertn. (Nymphaeaceae) is commonly called lotus and its leaves are widely been used as functional ingredients due to its antioxidant activity. For maximum efficacy, optimized extraction condition was... -
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- Diagnostic Reference Levels for Adult Nuclear Medicine Imaging Established from the National Survey in Korea
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Song HC, Na MH, Kim J, Cho SG, Park JK, Kang KW, Korean Society of Nuclear Medicine Diagnostic Reference Level Task Force
- KMID: 2446887
- Nucl Med Mol Imaging.
- 2019 Feb;53(1):64-70.
- doi: 10.1007/s13139-019-00585-y
PURPOSE: There is substantial need for optimizing radiation protection in nuclear medicine imaging studies. However, the diagnostic reference levels (DRLs) have not yet been established for nuclear medicine imaging studies... -
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- User-Friendly Vendor-Specific Guideline for Pediatric Cardiothoracic Computed Tomography Provided by the Asian Society of Cardiovascular Imaging Congenital Heart Disease Study Group: Part 1. Imaging Techniques
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Hong SH, Goo HW, Maeda E, Choo KS, Tsai IC, Asian Society of Cardiovascular Imaging Congenital Heart Disease Study Group
- KMID: 2438250
- Korean J Radiol.
- 2019 Feb;20(2):190-204.
- doi: 10.3348/kjr.2018.0571
Optimal performance of pediatric cardiothoracic computed tomography (CT) is technically challenging and may need different approaches for different types of CT scanners. To meet the technical demands and improve clinical... -
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- Dosimetric and Radiobiological Evaluation of Dose Volume Optimizer (DVO) and Progressive Resolution Optimizer (PRO) Algorithm against Photon Optimizer on IMRT and VMAT Plan for Prostate Cancer
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Kim YL, Chung JB, Kang SH, Eom KY, Song C, Kim IA, Kim JS, Lee JW
- KMID: 2434644
- Prog Med Phys.
- 2018 Dec;29(4):106-114.
- doi: 10.14316/pmp.2018.29.4.106
This study aimed to compare the performance of previous optimization algorithms against new a photon optimizer (PO) algorithm for intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) plans... -
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- Optimization of Extraction Conditions and Quantitative Analysis of Isoquercitrin and Caffeic Acid from Aster scaber
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Lee JS, Quilantang NG, Nam KW, Piao XL, Chung MJ, Lee S
- KMID: 2422013
- Nat Prod Sci.
- 2018 Sep;24(3):199-205.
- doi: 10.20307/nps.2018.24.3.199
To determine the optimum extraction conditions that give the highest yield of isoquercitrin and caffeic acid from Aster scaber, the effects of four extraction variables (solvent concentrations, extraction time, number... -
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- Is It Better to Enter a Volume CT Dose Index Value before or after Scan Range Adjustment for Radiation Dose Optimization of Pediatric Cardiothoracic CT with Tube Current Modulation?
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Goo HW
- KMID: 2413698
- Korean J Radiol.
- 2018 Aug;19(4):692-703.
- doi: 10.3348/kjr.2018.19.4.692
OBJECTIVE: To determine whether the body size-adapted volume computed tomography (CT) dose index (CTD(vol)) in pediatric cardiothoracic CT with tube current modulation is better to be entered before or after... -
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- Optimal Monochromatic Imaging of Spectral Computed Tomography Potentially Improves the Quality of Hepatic Vascular Imaging
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Yin XP, Gao BL, Li CY, Zhou H, Zhao L, Zheng YT, Zhao YX
- KMID: 2413687
- Korean J Radiol.
- 2018 Aug;19(4):578-584.
- doi: 10.3348/kjr.2018.19.4.578
OBJECTIVE: To investigate the efficiency of spectral computed tomography (CT) optimal monochromatic images in improving imaging quality of liver vessels. MATERIALS AND METHODS: The imaging data of 35 patients with abdominal... -
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