- Melatonin Protects Bone Microarchitecture against Deterioration due to High-Fat Diet-Induced Obesity
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Kim B, Kim YJ, Kim JH, Park K, Ku H, Choi YS
- KMID: 2540506
- J Bone Metab.
- 2023 Feb;30(1):69-75.
- doi: 10.11005/jbm.2023.30.1.69
Background: We evaluated the protective effects of melatonin against high-fat diet (HFD)-induced deterioration of bone microarchitecture using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods: Four-week-old male C57BL/6 mice were divided into... -
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- Melatonin Attenuates Mitochondrial Damage in Aristolochic AcidInduced Acute Kidney Injury
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Sun J, Pan J, Liu Q, Cheng J, Tang Q, Ji Y, Cheng K, wang R, Liu L, Wang D, Wu N, Zheng X, Li J, Zhang X, Zhu Z, Ding Y, Zheng F, Li J, Zhang Y, Yuan Y
- KMID: 2537586
- Biomol Ther.
- 2023 Jan;31(1):97-107.
- doi: 10.4062/biomolther.2022.054
Aristolochic acid (AA), extracted from Aristolochiaceae plants, plays an essential role in traditional herbal medicines and is used for different diseases. However, AA has been found to be nephrotoxic and... -
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- Melatonin and melatonergic drugs in sleep disorders
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Kim HK, Yang KI
- KMID: 2538878
- Transl Clin Pharmacol.
- 2022 Dec;30(4):163-171.
- doi: 10.12793/tcp.2022.30.e21
Melatonin is an endogenous chronobiological regulator secreted mainly from the pineal gland, which has been used as a dietary supplement in the treatment of sleep problems, including insomnia, parasomnia, and... -
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- Safety issues regarding melatonin use in child and adolescent patients with sleep problems
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Moon E, Lee JH
- KMID: 2538856
- Kosin Med J.
- 2022 Dec;37(4):264-270.
- doi: 10.7180/kmj.22.142
Several studies have reported that melatonin may be effective in treating sleep problems in children and adolescents. However, evidence regarding the safety of melatonin use in children and adolescents in... -
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- Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa
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Su S, Zhao Q, Dan L, Lin Y, Li X, Zhang Y, Yang C, Dong Y, Li X, Regazzi R, Sun C, Chu X, Lu H
- KMID: 2537291
- Endocrinol Metab.
- 2022 Dec;37(6):901-917.
- doi: 10.3803/EnM.2022.1565
Background: Chronic exposure to elevated levels of saturated fatty acids results in pancreatic β-cell senescence. However, targets and effective agents for preventing stearic acid-induced β-cell senescence are still lacking. Although... -
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- Cutaneous Photorejuvenation of Light Emitting Diodes via the Melatonin Membrane Receptor Pathway
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Bae SH, Park JH, Kim SH, Yun SJ, Kim JG, Lee JB
- KMID: 2536299
- Ann Dermatol.
- 2022 Dec;34(6):401-411.
- doi: 10.5021/ad.21.092
Background: Melatonin receptors are present in the human skin and retina. These receptors can be stimulated by light emitting diodes (LEDs) at specific wavelengths, thereby inducing cutaneous photorejuvenation. However, the... -
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- Melatonin and selenium supplementation in extenders improves the post-thaw quality parameters of rat sperm
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Shahandeh E, Ghorbani M, Mokhlesabadifarahani T, Bardestani F
- KMID: 2531709
- Clin Exp Reprod Med.
- 2022 Jun;49(2):87-92.
- doi: 10.5653/cerm.2022.05267
Objective: The aim of this study was to determine the effects of melatonin and selenium in freezing extenders on frozen-thawed rat sperm. Methods: Semen samples were collected from 20 adult male... -
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- Melatonin and Alzheimer’s Disease: A Mini-Review
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Um YH, Lim HK
- KMID: 2529486
- J Korean Geriatr Psychiatry.
- 2022 Apr;26(1):8-11.
- doi: 10.47825/jkgp.2022.26.1.8
Melatonin is a hormone with neuroregulatory, antioxidant and anti-inflammatory properties. Its benevolent effects on Alzheimer’s disease (AD) has been replicated in both animal models and clinical studies. Melatonin was effective... -
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- Melatonin Protects Chronic Kidney Disease Mesenchymal Stem/Stromal Cells against Accumulation of Methylglyoxal via Modulation of Hexokinase-2 Expression
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Go G, Yoon YM, Yoon S, Lee G, Lim JH, Han SY, Lee SH
- KMID: 2524144
- Biomol Ther.
- 2022 Jan;30(1):28-37.
- doi: 10.4062/biomolther.2021.058
Treatment options for patients with chronic kidney disease (CKD) are currently limited; therefore, there has been significant interest in applying mesenchymal stem/stromal cell (MSC)-based therapy to treat CKD. However, MSCs... -
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- Melatonin modulates nitric oxide-regulated WNK-SPAK/OSR1-NKCC1 signaling in dorsal raphe nucleus of rats
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Yang HJ, Kim MJ, Kim SS, Cho YW
- KMID: 2519407
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):449-457.
- doi: 10.4196/kjpp.2021.25.5.449
The sleep-wake cycle is regulated by the alternating activity of sleep- and wake-promoting neurons. The dorsal raphe nucleus (DRN) secretes 5-hydroxytryptamine (5-HT, serotonin), promoting wakefulness. Melatonin secreted from the pineal... -
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- The Effect of Laughter Therapy on Sleep in Community-dwelling Elders with Sleep Disorders
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Lee YS, Park H
- KMID: 2519684
- J Korean Acad Fundam Nurs.
- 2021 Aug;28(3):297-310.
- doi: 10.7739/jkafn.2021.28.3.297
Purpose: The purpose of this study was to examine the effect of laughter therapy on the quality and quantity of sleep in elders with sleep disorders. Methods: This was a quasi-experimental... -
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- Melatonin mitigates the adverse effect of hypoxia during myocardial differentiation in mouse embryonic stem cells
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Lee JH, Yoo YM, Lee B, Jeong S, Tran DN, Jeung EB
- KMID: 2518800
- J Vet Sci.
- 2021 Jul;22(4):e54.
- doi: 10.4142/jvs.2021.22.e54
Background: Hypoxia causes oxidative stress and affects cardiovascular function and the programming of cardiovascular disease. Melatonin promotes antioxidant enzymes such as superoxide dismutase, glutathione reductase, glutathione peroxidase, and catalase. Objectives: This... -
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- Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamopituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats
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Kadir ER, Imam A, Olajide OJ, Ajao MS
- KMID: 2516905
- Anat Cell Biol.
- 2021 Jun;54(2):212-224.
- doi: 10.5115/acb.20.215
Bisphenol A is a chemical used primarily as a monomer in the production of polycarbonate plastics and epoxy resins. It is a synthetic chemical compound that is produced in billions... -
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- The Effect of Auricular Acupressure on Sleep in Older Adults with Sleep Disorders
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Lee JH, Park H
- KMID: 2540552
- J Korean Gerontol Nurs.
- 2021 May;23(2):117-128.
- doi: 10.17079/jkgn.2021.23.2.117
Purpose: The purpose of this study was to determine the effects of auricular acupressure on sleep in older adults with sleep disorders. Methods: This was a randomized, single-blind, sham-controlled study. The... -
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- Relationship among Cognition, Sleep Patterns, Salivary Melatonin Level and Sleep Disorder Inventory of Older Adults in Nursing Homes
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Shim H, Sohng KY
- KMID: 2519498
- J Korean Biol Nurs Sci.
- 2021 May;23(2):151-158.
- doi: 10.7586/jkbns.2021.23.2.151
Purpose: The purpose of this study was to investigate sleep quality in older adults in nursing home with objective data collection. Methods: Participants included 74 older adults in nursing homes in... -
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- Effects of Organic Light-Emitting Diodes on Circadian Rhythm and Sleep
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Jo H, Park HR, Choi SJ, Lee SY, Kim SJ, Joo EY
- KMID: 2516021
- Psychiatry Investig.
- 2021 May;18(5):471-477.
- doi: 10.30773/pi.2020.0348
Objective Organic light-emitting diodes (OLEDs) emit less blue light than traditional light-emitting diodes (LEDs), and we previously found that early-night OLED light exposure (LE) delays the melatonin phase by less... -
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- Association between the Arylalkylamine N-Acetyltransferase (AANAT) Gene and Seasonality in Patients with Bipolar Disorder
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Yang SY, Hong KS, Cho Y, Cho EY, Choi Y, Kim Y, Park T, Ha K, Baek JH
- KMID: 2516019
- Psychiatry Investig.
- 2021 May;18(5):453-462.
- doi: 10.30773/pi.2020.0436
Objective Bipolar disorder (BD) is complex genetic disorder. Therefore, approaches using clinical phenotypes such as biological rhythm disruption could be an alternative. In this study, we explored the relationship between... -
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- Recent Update on Treatment and Management of Rapid Eye Movement Sleep Behavior Disorder
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Byun JI, Shin WC
- KMID: 2515613
- J Korean Neurol Assoc.
- 2021 May;39(2):68-74.
- doi: 10.17340/jkna.2021.2.2
Rapid eye movement sleep behavior disorder (RBD) is a parasomnia that is characterized by dream-enactment behavior, which can often result in sleep related injury. RBD is strongly associated with neurodegenerative... -
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- Changes Caused by the Melatonergic System in Young Patients with Mood Disorders: A Literature Review
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Lee JH, Moon E
- KMID: 2525641
- Mood Emot.
- 2021 Mar;19(1):1-10.
- doi: 10.35986/me.2021.19.1.1
The abnormalities caused by the melatonergic system have been associated with psychiatric disorders, such as Alzheimer’s dementia and schizophrenia, as well as with the pathogenesis of mood disorders. Abnormal melatonin... -
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- Trough Melatonin Levels Differ between Early and Late Phases of Alzheimer Disease
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Lin CH, Chiu CC, Lane HY
- KMID: 2513399
- Clin Psychopharmacol Neurosci.
- 2021 Feb;19(1):135-144.
- doi: 10.9758/cpn.2021.19.1.135
Objective: Melatonin has been considered to have an essential role in the pathophysiology of Alzheimer’s disease (AD) for its regulatory function on circadian rhythm and interaction with glutamate for the... -
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