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Intestinal microbiota and inflammatory bowel diseases

Eun CS

Background: The prevalence of inflammatory bowel diseases (IBD) has been rapidly increasing over the past several decades in Korea. IBD appears to be resulted from inappropriate and chronic activation of...
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Helicobacter pylori Eradication Therapy-associated Diarrhea

Jo HG, Kim YS

Eradication of Helicobacter pylori has contributed to the treatment of peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Moreover, it has possibly decreased the prevalence of gastric cancer. However, eradication therapy...
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Impact of the Human Microbiome on Nephrolithiasis

Jung HD, Lee JY

Nephrolithiasis has many causes, and its prevalence is increasing worldwide. The interest in the human microbiome is growing because of the advance of new diagnostic techniques, and recent studies have...
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Microbiome and Cancer Immunotherapy

Hong M, Jung M

Immune checkpoint inhibitors (ICIs) have achieved promising clinical results in cancer treatment over the past decade. However, the efficacy of ICIs is less than 30% in most tumor types, and...
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Iron Reshapes the Gut Microbiome and Host Metabolism

Botta A, Barra NG, Lam NH, Chow S, Pantopoulos K, Schertzer JD, Sweeney G

Compelling studies have established that the gut microbiome is a modifier of metabolic health. Changes in the composition of the gut microbiome are influenced by genetics and the environment, including...
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Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals

Shen W, Sun J, Li Z, Yao F, Lin K, Jiao X

Background/Aim: It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types...
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Compositional and Functional Changes in the Gut Microbiota in Irritable Bowel Syndrome Patients

Lee SM, Kim N, Yoon H, Kim YS, Choi SI, Park JH, Lee DH

Background/Aims: This study aimed to characterize the changes in the gut microbiota of irritable bowel syndrome (IBS) patients and to investigate the consequent alterations in bacterial functions. Methods: We performed 16S...
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Best Achievements in Translational and Basic Thyroidology in 2020

Cho SW, Park YJ

This review discusses articles published in 2020 that presented noteworthy achievements in translational and basic thyroidology. Previously unresolved questions about thyroid hormone receptor actions and signaling mechanisms were answered using...
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Proton Pump Inhibitor Use Increases Pyogenic Liver Abscess Risk: A Nationwide Cohort Study

Oh JH, Kang D, Kang W, Guallar E, Cho J, Min YW

  • KMID: 2521156
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):555-564.
  • doi: 10.5056/jnm20221
Background/Aims Proton pump inhibitors (PPIs) increase gastric pH and alter the gut microbiome. An increased risk for infectious diseases has been reported in PPI users. However, little is known about the...
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Brain to Belly: Abdominal Variants of Migraine and Functional Abdominal Pain Disorders Associated With Migraine

LenglarT L, Caula C, Moulding T, Lyles A, Wohrer D, Titomanlio L

  • KMID: 2521148
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):482-494.
  • doi: 10.5056/jnm20290
Migraine is one of the most frequent causes of primary headache and 9% of children suffer from migraines. Most children will continue to experience migraine attacks as adults, therefore it...
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The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease

Jennison E, Byrne CD

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2...
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Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders

Singh R, Zogg H, Wei L, Bartlett A, Ghoshal UC, Rajender S, Ro S

  • KMID: 2510059
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):19-34.
  • doi: 10.5056/jnm20149
Of all microorganisms in the human body, the largest and most complex population resides in the gastrointestinal (GI) tract. The gut microbiota continuously adapts to the host environment and serves...
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Systems Biology: A Multi-Omics Integration Approach to Metabolism and the Microbiome

Son JW, Shoaie S, Lee S

The complex and dynamic nature of human physiology, as exemplified by metabolism, has often been overlooked due to the lack of quantitative and systems approaches. Recently, systems biology approaches have...
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The Gut Microbiome: Human Health and Inflammatory Skin Diseases

Mann EA, Bae E, Kostyuchek D, Chung HJ, McGee JS

The human microbiome is a rich environment consisting ofbacteria, fungi and other commensal microorganisms of thegut, mucosa and skin. The functional role of the gut microbiomeincludes facilitation in metabolism of...
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Melatonin in the colon modulates intestinal microbiota in response to stress and sleep deprivation

Park YS, Kim SH, Park JW, Kho Y, Seok PR, Shin JH, Choi YJ, Jun JH, Jung HC, Kim EK

Background/Aims: Stress is closely related to the deterioration of digestive disease. Melatonin has potent anti-inflammatory properties. The objective of this study was to determine the effect of water stress (WS)...
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Gut Microbiota and Pancreatobiliary System

Ryu KH

The gut microbiota is part of the human body that is involved in body metabolism and the occurrence of various diseases. Detecting and analyzing their genetic information (microbiome) is as...
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Combination of Probiotics and Salvia miltiorrhiza Polysaccharide Alleviates Hepatic Steatosis via Gut Microbiota Modulation and Insulin Resistance Improvement in High Fat-Induced NAFLD Mice

Wang W, Xu AL, Li ZC, Li Y, Xu SF, Sang HC, Zhi F

Background: Nonalcoholic fatty liver disease (NAFLD) increases the risk of hepatocellular carcinoma, which is currently the leading cause of obesity-related cancer deaths in middle-aged men. Methods: Probiotics with lipid-lowering function were...
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Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant

Park YM, Lee SY, Kang MJ, Kim BS, Lee MJ, Jung SS, Yoon JS, Cho HJ, Lee E, Yang SI, Seo JH, Kim HB, Suh DI, Shin YH, Kim KW, Ahn K, Hong SJ

PURPOSE: The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and...
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Sarcopenia and Muscle Aging: A Brief Overview

Dao T, Green AE, Kim YA, Bae SJ, Ha KT, Gariani K, Lee Mr, Menzies KJ, Ryu D

The world is facing the new challenges of an aging population, and understanding the process of aging has therefore become one of the most important global concerns. Sarcopenia is a...
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Mental Disorders Linked to Crosstalk between The Gut Microbiome and The Brain

Choi TY, Choi YP, Koo JW

  • KMID: 2510503
  • Exp Neurobiol.
  • 2020 Dec;29(6):403-416.
  • doi: 10.5607/en20047
Often called the second brain, the gut communicates extensively with the brain and vice versa. The conversation between these two organs affects a variety of physiological mechanisms that are associated...
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