- Vessel Wall Changes on Serial High-Resolution MRI and the Use of Cilostazol in Patients With Adult-Onset Moyamoya Disease
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Kim JY, Kim HJ, Choi EH, Pan KH, Chung JW, Seo WK, Kim GM, Jee TK, Yeon JY, Kim JS, Hong SC, Seong MJ, Cha J, Kim KH, Jeon P, Bang OY
- KMID: 2534745
- J Clin Neurol.
- 2022 Nov;18(6):610-618.
- doi: 10.3988/jcn.2022.18.6.610
Background and Purpose The natural course of adult-onset moyamoya disease (MMD) is unknown, and there is no medical treatment that halts its progression. We hypothesized that progressive shrinkage of large... -
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- Comparative Study of Ex Vivo Antiplatelet Activity of Aspirin and Cilostazol in Patients with Diabetes and High Risk of Cardiovascular Disease
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Hong S, Lee WJ, Park CY
- KMID: 2529215
- Endocrinol Metab.
- 2022 Apr;37(2):233-242.
- doi: 10.3803/EnM.2021.1353
Background: The role of aspirin in primary cardiovascular disease prevention in patients with diabetes remains controversial. However, some studies have suggested beneficial effects of cilostazol on cardiovascular disease in patients... -
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- Treatment of In-Stent Stenosis Following Flow Diversion of Intracranial Aneurysms with Cilostazol and Clopidogrel
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Dowlati E, Pasko KBD, Liu J, Miller CA, Felbaum DR, Sur S, Chang JJ, Liu AH, Armonda RA, Mai JC
- KMID: 2522044
- Neurointervention.
- 2021 Nov;16(3):285-292.
- doi: 10.5469/neuroint.2021.00290
In-stent stenosis is a feared complication of flow diversion treatment for cerebral aneurysms. We present 2 cases of patients treated with pipeline flow diversion for unruptured cerebral aneurysms. Initial perioperative... -
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- Protective Effect of Cilostazol Against Restraint Stress Induced Heart Failure in Post-Myocardial Infarction Rat Model
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Lee MY, Kim NH, Ko JS
- KMID: 2506827
- Chonnam Med J.
- 2020 Sep;56(3):180-185.
- doi: 10.4068/cmj.2020.56.3.180
Cilostazol, a phosphodiesterase III inhibitor, has antiplatelet and vasodilatory effects. It also has pleiotrophic effects including reduction of oxygen free radicals, positive chronotropic effect and inhibition of intracellular Ca2+ associated catecholamine... -
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- Cilostazol ameliorates diabetic nephropathy by inhibiting highglucose- induced apoptosis
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Chian CW, Lee YS, Lee YJ, Chen YH, Wang CP, Lee WC, Lee HJ
- KMID: 2505775
- Korean J Physiol Pharmacol.
- 2020 Sep;24(5):403-412.
- doi: 10.4196/kjpp.2020.24.5.403
Diabetic nephropathy (DN) is a hyperglycemia-induced progressivedevelopment of renal insufficiency. Excessive glucose can increase mitochondrialreactive oxygen species (ROS) and induce cell damage, causing mitochondrial dysfunction.Our previous study indicated that cilostazol... -
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- Combination therapy with cilostazol, aripiprazole, and donepezil protects neuronal cells from β-amyloid neurotoxicity through synergistically enhanced SIRT1 expression
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Heo HJ, Park SY, Lee YS, Shin HK, Hong KW, Kim CD
- KMID: 2503323
- Korean J Physiol Pharmacol.
- 2020 Jul;24(4):299-310.
- doi: 10.4196/kjpp.2020.24.4.299
Alzheimer’s disease (AD) is a multi-faceted neurodegenerative disease. Thus, current therapeutic strategies require multitarget-drug combinations to treat or prevent the disease. At the present time, single drugs have proven to... -
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- Changes in High-Density Lipoprotein Cholesterol and Risks of Cardiovascular Events: A Post Hoc Analysis from the PICASSO Trial
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Lee EJ, Kwon SU, Park JH, Kim YJ, Hong KS, Yu S, Hwang YH, Lee JS, Lee J, Rha JH, Heo SH, Ahn SH, Seo WK, Park JM, Lee JH, Kwon JH, Sohn SI, Jung JM, Kim HY, Kim EG, Kim SH, Cha JK, Park MS, Nam HS, Kang DW, on Behalf of PICASSO Investigators
- KMID: 2500923
- J Stroke.
- 2020 Jan;22(1):108-118.
- doi: 10.5853/jos.2019.02551
Background and purpose Whether pharmacologically altered high-density lipoprotein cholesterol (HDL-C) affects the risk of cardiovascular events is unknown. Recently, we have reported the Prevention of Cardiovascular Events in Asian Patients... -
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- Clinical Outcomes of Antiplatelets Combined with Statins in Patients with Ischemic Heart Disease
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Kim C, Lee J, Park RW, Lee S
- KMID: 2470463
- Korean J Clin Pharm.
- 2019 Dec;29(4):254-266.
- doi: 10.24304/kjcp.2019.29.4.254
BACKGROUND: Patients with cardiovascular risks are recommended to use statins and antiplatelet agents to prevent major cerebrocardiovascular events (MACCE). Antiplatelet agents also possess anti-inflammatory and antioxidant effects, in addition to... -
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- A Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes: Protocol of a Multicenter, Randomized Controlled Trial
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Han HJ, Kim BC, Youn YC, Jeong JH, Kim JH, Lee JH, Park KH, Park KW, Kim EJ, Oh MS, Shim YS, Park HY, Yoon B, Yoon SJ, Cho SJ, Park KC, Na DL, Park SA, Lee JM, Choi SH
- KMID: 2466757
- Dement Neurocogn Disord.
- 2019 Dec;18(4):138-148.
- doi: 10.12779/dnd.2019.18.4.138
BACKGROUND AND PURPOSE: Cerebral small vessel disease (CSVD) is the most common cause of vascular dementia and a major contributor to mixed dementia. CSVD is characterized by progressive cerebral white... -
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- Population pharmacodynamics of cilostazol in healthy Korean subjects
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Jung YS, Chae D, Park K
- KMID: 2413833
- Transl Clin Pharmacol.
- 2018 Jun;26(2):93-98.
- doi: 10.12793/tcp.2018.26.2.93
Cilostazol is used for the treatment of intermittent claudication, ulceration and pain. This study was conducted to develop a population pharmacodynamic (PD) model for cilostazol's closure time (CT) prolongation effect... -
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- Cilostazol attenuates kainic acid-induced hippocampal cell death
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Park YS, Jin Z, Jeong EA, Yi CO, Lee JY, Park IS, Roh GS
- KMID: 2398556
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):63-70.
- doi: 10.4196/kjpp.2018.22.1.63
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate... -
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- Oral Administration of Cilostazol Increases Ocular Blood Flow in Patients with Diabetic Retinopathy
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Hwang DJ, Shin JY, Yu HG
- KMID: 2373468
- Korean J Ophthalmol.
- 2017 Apr;31(2):123-131.
- doi: 10.3341/kjo.2017.31.2.123
PURPOSE: To investigate the effect of cilostazol on ocular hemodynamics and to determine whether the administration of cilostazol increases the ocular blood flow in patients with diabetic retinopathy. METHODS: This prospective... -
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- Pharmacokinetic characteristics of cilostazol 200 mg controlled-release tablet compared with two cilostazol 100 mg immediate-release tablets (Pletal) after single oral dose in healthy Korean male volunteers
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Son JD, Cho SM, Choi YW, Kim SH, Kwon IS, Jin EH, Kim JW, Hong JH
- KMID: 2413840
- Transl Clin Pharmacol.
- 2016 Dec;24(4):183-188.
- doi: 10.12793/tcp.2016.24.4.183
Cilostazol controlled-release (CR) tablets have recently been developed by Korea United Pharm (Seoul, Korea). The tablets use a patented double CR system, which improves drug compliance by allowing "once daily"... -
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- Monitoring the Antiplatelet Effect of Cilostazol with Light Transmission Aggregometer: Two Cases of Possible Cilostazol Resistance
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Shim H, Jang S, Park CJ, Chi HS, Lee SW, Park SW
- KMID: 2353422
- Lab Med Online.
- 2016 Oct;6(4):214-220.
- doi: 10.3343/lmo.2016.6.4.214
BACKGROUND: Coronary artery disease is an important cause of death in adults and stent insertion is one of the treatment modalities. The most severe adverse effect of a stent insertion... -
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- Successful sequential desensitization in a patient with drug hypersensitivity to three kinds of antiplatelet agents
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Kim GW, Kang SY, Sohn KH, Kim SH, Cho SH, Min KU, Chang YS
- KMID: 2391928
- Allergy Asthma Respir Dis.
- 2016 Sep;4(5):374-377.
- doi: 10.4168/aard.2016.4.5.374
Antiplatelet agents, such as aspirin, clopidogrel, and cilostazol, are essential for the treatment and prevention of cardiovascular, cerebrovascular, and peripheral vascular diseases. A 53-year-old male with aspirin hypersensitivity developed dizziness,... -
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- The Effect of Cilostazol on Arterial Stiffness in Patients Undergoing Percutaneous Coronary Intervention
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Cho SY, Kim KH, Ahn JH, Kang YR, Koh JS, Hwang SJ, Park Y, Jeong YH, Kwak CH, Hwang JY, Park JR
- KMID: 2269001
- Korean J Med.
- 2015 Sep;89(3):295-304.
- doi: 10.3904/kjm.2015.89.3.295
BACKGROUND/AIMS: Increased arterial stiffness is a well-known risk factor for cardiovascular disease. Cilostazol, a phosphodiesterase type 3 inhibitor, is a unique antiplatelet agent with vasodilatory and vasoprotective effects. Therefore, we... -
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- Spontaneous abdominal intramuscular hematoma in a non-dialysis chronic kidney disease patient under cilostazol therapy
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Kang S, Yu HM, Na HY, Ko YK, Kwon SW, Lim CH, Kim SW, Jo YI
- KMID: 1909824
- Yeungnam Univ J Med.
- 2014 Dec;31(2):139-143.
- doi: 10.12701/yujm.2014.31.2.139
Spontaneous intramuscular hematoma of the abdominal wall is a rare condition characterized by acute abdominal pain. It is often misdiagnosed as a surgical condition. It used to be associated with... -
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- Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1
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Jung YA, Kim HK, Bae KH, Seo HY, Kim HS, Jang BK, Jung GS, Lee IK, Kim MK, Park KG
- KMID: 2155338
- Exp Mol Med.
- 2014 Jan;46(1):e73.
- doi: 10.1038/emm.2013.143
Hepatic steatosis is common in obese individuals with hyperinsulinemia and is an important hepatic manifestation of metabolic syndrome. Sterol regulatory binding protein-1c (SREBP-1c) is a master regulator of lipogenic gene... -
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- Adjunctive Cilostazol versus High Maintenance Dose of Clopidogrel in Patients with Hyporesponsiveness to Chronic Clopidogrel Therapy
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Lee GY, Hahn JY, Lee SY, Kim HJ, Kim JH, Lee SY, Song YB, Choi SH, Choi JH, Gwon HC
- KMID: 1776915
- Yonsei Med J.
- 2013 Jan;54(1):34-40.
- doi: 10.3349/ymj.2013.54.1.34
PURPOSE: Whether addition of cilostazol is superior to increasing dose of clopidogrel in patients with hyporesponsiveness to chronic clopidogrel therapy is unknown. MATERIALS AND METHODS: We studied 73 patients with hyporesponsiveness... -
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- Spontaneous Spinal Epidural Hematoma in a Patient on Cilostazol
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Baek SH, Lee HS, Kang JH, Shin J, Lee H, Kim I, Yang SJ, Kim JS, Shin DI, Lee SH, Lee SS
- KMID: 2288706
- Korean J Stroke.
- 2012 Dec;14(3):170-172.
Cilostazol is a phosphodiesterase inhibitor that has been shown to have similar efficacy in stroke prevention but fewer hemorrhagic events compared with aspirin. We report a case of spontaneous spinal... -
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