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Famine exposure in early life and type 2 diabetes in adulthood: findings from prospective studies in China

Ning F, Zhao J, Zhang L, Wang W, Sun X, Song X, Zhang Y, Xin H, Gao W, Gao R, Zhang D, Pang Z

BACKGROUND/OBJECTIVES: This study examined the relationship between famine exposure in early life and the risk of type 2 diabetes in adulthood during the 1959–1961 Chinese Famine. SUBJECTS/METHODS: A total of 3,418...
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Does H3K27M Mutation Impact Survival Outcome of High-Grade Spinal Cord Astrocytoma?

Zhang F, Cheng L, Ding Z, Wang S, Zhao X, Zhao Z, Liang C, Wu K, Zhang D, Wang Y, Fan T

Objective: To evaluate the impact of H3K27M mutation in the prognosis of histological high-grade intramedullary astrocytoma. Methods: A total of 78 patients who were diagnosed with high-grade spinal cord astrocytoma were...
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Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model

Zhang YD, Zhu ZS, Zhang D, Zhang Z, Ma B, Zhao SC, Xue F

This study aimed to investigate the effect of Patched-1 (PTC1) and PTC2 silencing in a rat model, on Hedgehog (Hh) pathway-mediated recovery from spinal cord injury (SCI). An analytical emphasis...
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Babeisa duncani infection alters gut microbiota profile in hamsters

The genus Babesia includes parasites that can induce human and animal babesiosis, which are common in tropical and subtropical regions of the world. The gut microbiota has not been examined...
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Addendum to: Effects of Exercise and a High-Fat, High-Sucrose Restriction Diet on Metabolic Indicators, Nr4a3, and Mitochondria-Associated Protein Expression in the Gastrocnemius Muscles of Mice with Diet-Induced Obesity (J Obes Metab Syndr 2021;30:44-54)

Lee JH, Zhang D, Kwak SE, Shin HE, Song W

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Multilevel Pedicle Subtraction Osteotomy for Correction of Thoracolumbar Kyphosis in Ankylosing Spondylitis: Clinical Effect and Biomechanical Evaluation

Lv X, Nuertai Y, Wang Q, Zhang D, Hu X, Liu J, Zeng Z, Huang R, Huang Z, Zhao Q, Li W, Zhang Z, Gao L

Objective: To compare the clinical outcomes and biomechanical characteristics of 1-, 2-, and 3-level pedicle subtraction osteotomy (PSO), and establish selection criteria based on preoperative radiographic parameters. Methods: Patients undergone PSO...
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Reference Intervals for Thyroid-Associated Hormones and the Prevalence of Thyroid Diseases in the Chinese Population

Zou Y, Wang D, Cheng X, Ma C, Lin S, Hu Y, Yu S, Xia L, Li H, Yin Y, Liu H, Zhang D, Zhang K, Lian X, Xu T, Qiu L

Background: Thyroid diseases are highly prevalent worldwide, but their diagnosis remains a challenge. We established reference intervals (RIs) for thyroid-associated hormones and evaluated the prevalence of thyroid diseases in China. Methods:...
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Evaluation of expression of the Wnt signaling components in canine mammary tumors via RT² Profiler PCR Array and immunochemistry assays

Yu F, Rasotto R, Zhang H, Pei S, Zhou B, Yang X, Jin Y, Zhang D, Lin D

The Wnt signaling pathway and its key component β-catenin have critical roles in the development of diseases such as tumors in mammals. However, little has been reported about involvement of...
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Risk Factors for the Rupture of Bifurcation Intracranial Aneurysms Using CT Angiography

Wang GX, Zhang D, Wang ZP, Yang LQ, Zhang L, Wen L

PURPOSE: To investigate the clinical and morphological characteristics in relation to risk of bifurcation intracranial aneurysm rupture. MATERIALS AND METHODS: Data from 202 consecutive patients with 219 bifurcation aneurysms (129 ruptured...
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Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge

Zhang D, Zhou Y, Ma Y, Chen P, Tang J, Yang B, Li H, Liang M, Xue Y, Liu Y, Zhang J, Wang X

Background: Long coronavirus disease 2019 (COVID-19) in recovered patients (RPs) is gradually recognized by more people. However, how long it will last and the underlining mechanism remains unclear. Methods: We conducted...
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Induced Intermediate Mesoderm Combined with Decellularized Kidney Scaffolds for Functional Engineering Kidney

Zhang J, Li K, Kong F, Sun C, Zhang D, Yu X, Wang X, Li X, Liu T, Shao G, Guan Y, Zhao S

BACKGROUND: Chronic kidney disease is a severe threat to human health with no ideal treatment strategy. Mature mammalian kidneys have a fixed number of nephrons, and regeneration is difficult once...
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Effect of a Single Bout of Exercise on Autophagy Regulation in Skeletal Muscle of High-Fat High-Sucrose Diet-Fed Mice

Zhang D, Lee JH, Kwak SE, Shin HE, Zhang Y, Moon HY, Shin DM, Seong JK, Tang L, Song W

BACKGROUND: Autophagy maintains metabolic homeostasis of muscles, and its impairment may cause muscle dysfunction. Exercise can improve muscle dysfunction induced by long-term high-fat diet. This study aimed to explore the...
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An Itelligent System for Diagnosis of Coronary Artery Disease with BP Neural Networks

Bai Y, Hou L, Wu S, Zhang D

  • KMID: 2330786
  • J Korean Soc Med Inform.
  • 2007 Jun;13(2):147-152.
OBJECTIVE: In this paper, an intelligent system using BP neural networks (BPNN) is presented for early detection coronary artery disease (CAD). METHODS: Based on the four features of ECG signals and...
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Exercise, the Gut Microbiome, and Frailty

Shin HE, Kwak SE, Lee JH, Zhang D, Bae JH, Song W

The gut microbiome is deeply associated with both skeletal muscle and brain function. In particular, gut microbiome dysbiosis may accelerate age-related diseases by affecting these systems. Although there is increasing...
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Status of Iodine Intake and Comparison of Characteristics according to Iodine-sourced Food Intake Patterns of Chinese Adults: A Study Encompassing Three Regions with Different Iodine Nutritional Statuses

Zhang D, Ryu HK

Objectives: This study examines the status of iodine intake and compares the characteristics (region and thyroid disease prevalence) according to the iodine-sourced food intake pattern in Chinese adults. Methods: An online...
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Subspecialty Variation in Academic Citations of Orthopedic Surgery Publications

Zhang D, Blazar P, Earp BE

Background: The objective of this study was to assess the variation in academic citation and social media mentions across orthopedic subspecialties in general orthopedic surgery journals. Methods: An internet-based study was...
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Transcriptome and proteome analysis of pregnancy and postpartum anoestrus ovaries in yak

Chen Z, Wang J, Ma J, Li S, Huo S, Yang Y, Zhaxi Y, Zhao Y, Zhang D

Background: Domestic yaks are the most important livestock species on the Qinghai-Tibetan Plateau. Adult female yaks normally breed in the warm season (July to September) and enter anestrous in the...
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Generation of Urothelial Cells from Mouse-Induced Pluripotent Stem Cells

Zhang D, Sun F, Yao H, Wang D, Bao X, Wang J, Wu J

Background and Objectives: The search for a suitable alternative for urethral defect is a challenge in the field of urethral tissue engineering. Induced pluripotent stem cells (iPSCs) possess multipotential for...
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Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p

Pan J, Liu Z, Yang Z, Liang E, Fang C, Zhang D, Zhou X, Niu Y, Xin Z, Chen Y, Cai Q

Purpose: As the mechanism of interaction between circular RNAs (circRNAs) and microRNAs (miRNAs) in regulating the development of prostate cancer (PCa) is not clear, this study focuses on investigating these...
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Effects of Exercise and a High-Fat, High-Sucrose Restriction Diet on Metabolic Indicators, Nr4a3, and Mitochondria-Associated Protein Expression in the Gastrocnemius Muscles of Mice with Diet-Induced Obesity

Lee JH, Zhang D, Kwak SE, Shin HE, Song W

Background: Exercise and high fat, high sucrose restriction diets are well known treatments for obesity. The aim of this study was to measure the effects of those lifestyle interventions on...
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