- PRR16/Largen Induces Epithelial-Mesenchymal Transition through the Interaction with ABI2 Leading to the Activation of ABL1 Kinase
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Kang GJ, Park JH, Kim HJ, Kim EJ, Kim B, Byun HJ, Yu L, Nguyen TM, Nguyen TH, Kim KS, Huy HP, Rahman M, Kim YH, Jang JY, Park MK, Lee H, Choi CI, Lee K, Han HK, Cho J, Rho SB, Lee CH
- KMID: 2530999
- Biomol Ther.
- 2022 Jul;30(4):340-347.
- doi: 10.4062/biomolther.2022.066
Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis is associated with epithelial-mesenchymal metastasis (EMT). However, the specific signals that induce... -
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- Loss of EMP2 Inhibits Melanogenesis of MNT1 Melanoma Cells via Regulation of TRP-2
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Enkhtaivan E, Kim HJ, Kim B, Byun HJ, Yu L, Nguyen TM, Nguyen TH, Do PA, Kim EJ, Kim KS, Huy HP, Rahman M, Jang JY, Rho SB, Lee H, Kang GJ, Park MK, Kim NH, Choi CI, Lee K, Han HK, Cho J, Lee AY, Lee CH
- KMID: 2526823
- Biomol Ther.
- 2022 Mar;30(2):203-211.
- doi: 10.4062/biomolther.2022.001
Melanogenesis is the production of melanin from tyrosine by a series of enzyme-catalyzed reactions, in which tyrosinase and DOPA oxidase play key roles. The melanin content in the skin determines... -
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- CT Fractional Flow Reserve for the Diagnosis of Myocardial Bridging-Related Ischemia: A Study Using Dynamic CT Myocardial Perfusion Imaging as a Reference Standard
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Yu Y, Yu L, Dai X, Zhang J
- KMID: 2522928
- Korean J Radiol.
- 2021 Dec;22(12):1964-1973.
- doi: 10.3348/kjr.2021.0043
Objective: To investigate the diagnostic performance of CT fractional flow reserve (CT-FFR) for myocardial bridging-related ischemia using dynamic CT myocardial perfusion imaging (CT-MPI) as a reference standard. Materials and Methods: Dynamic... -
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- Dynamic CT Myocardial Perfusion Imaging in Patients without Obstructive Coronary Artery Disease: Quantification of Myocardial Blood Flow according to Varied Heart Rate Increments after Stress
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Yu L, Tao X, Dai X, Liu T, Zhang J
- KMID: 2509822
- Korean J Radiol.
- 2021 Jan;22(1):97-105.
- doi: 10.3348/kjr.2020.0249
Objective: The present study aimed to investigate the association between myocardial blood flow (MBF) quantified by dynamic CT myocardial perfusion imaging (CT-MPI) and the increments in heart rate (HR) after... -
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- The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene
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Kim S, Lee JH, Lee S, Shim S, Nguyen TT, Hwang J, Kim H, Choi YO, Hong J, Bae S, Jhun H, Yum H, Lee Y, Chan ED, Yu L, Azam T, Kim YD, Yeom SC, Yoo KH, Kang LW, Shin KC, Kim S
- KMID: 2511866
- Immune Netw.
- 2020 Oct;20(5):e41.
- doi: 10.4110/in.2020.20.e41
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense singlestranded RNA (+ssRNA) that causes coronavirus disease 2019 (COVID-19). The viral genome encodes twelve genes for viral replication and infection.... -
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- Therapeutic Effects of Fibroblast Growth Factor-21 on Diabetic Nephropathy and the Possible Mechanism in Type 1 Diabetes Mellitus Mice
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Weng W, Ge T, Wang Y, He L, Liu T, Wang W, Zheng Z, Yu L, Zhang C, Lu X
- KMID: 2513016
- Diabetes Metab J.
- 2020 Aug;44(4):566-580.
- doi: 10.4093/dmj.2019.0089
BackgroundFibroblast growth factor 21 (FGF21) has been only reported to prevent type 1 diabetic nephropathy (DN) in the streptozotocin-induced type 1 diabetes mellitus (T1DM) mouse model. However, the FVB (Cg)-Tg... -
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- Nucleos(t)ide Analogues for Reducing Hepatocellular Carcinoma in Chronic Hepatitis B Patients: A Systematic Review and Meta-Analysis
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Wang X, Liu X, Dang Z, Yu L, Jiang Y, Wang X, Yang Z
- KMID: 2508758
- Gut Liver.
- 2020 Mar;14(2):232-247.
- doi: 10.5009/gnl18546
Background/Aims: Studies have shown that nucleos(t)ide analogue (NA) treatment can reduce the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients, but it is unclear which NA is... -
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- Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
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Lin S, Yu L, Ni Y, He L, Weng X, Lu X, Zhang C
- KMID: 2470964
- Diabetes Metab J.
- 2020 Feb;44(1):158-172.
- doi: 10.4093/dmj.2018.0235
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated... -
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- Circular RNAs Regulate Cancer Onset and Progression via Wnt/β-Catenin Signaling Pathway
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Li YF, Zhang J, Yu L
- KMID: 2463790
- Yonsei Med J.
- 2019 Dec;60(12):1117-1128.
- doi: 10.3349/ymj.2019.60.12.1117
Cancer remains to be a major challenge for public health providers, and is the second leading cause of death worldwide. Therefore, it is imperative to explore the mechanisms underlying cancer... -
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- miR-1301/TRIAP1 Axis Participates in Epirubicin-Mediated Anti-Proliferation and Pro-Apoptosis in Osteosarcoma
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Yu L, Meng M, Bao Y, Zhang C, Gao B, Sa R, Luo W
- KMID: 2457479
- Yonsei Med J.
- 2019 Sep;60(9):832-841.
- doi: 10.3349/ymj.2019.60.9.832
PURPOSE: Epirubicin is one of the most effective drugs against osteosarcoma. miR-1301 is involved in the occurrence and development of osteosarcoma. Whether miR-1301 is responsible for the chemosensitivity of osteosarcoma... -
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- MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1
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Yang Q, Li J, Hu Y, Tang X, Yu L, Dong L, Chen D
- KMID: 2446954
- Yonsei Med J.
- 2019 Jun;60(6):500-508.
- doi: 10.3349/ymj.2019.60.6.500
PURPOSE: Lung adenocarcinoma (LA) is one of the major types of lung cancer. MicroRNAs (miRNAs) play an essential role in regulating responses of natural killer (NK) cells to cancer malignancy.... -
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- Comparative effects of angiotensin II and angiotensin-(4-8) on blood pressure and ANP secretion in rats
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Phuong HT, Yu L, Park BM, Kim SH
- KMID: 2395262
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):667-674.
- doi: 10.4196/kjpp.2017.21.6.667
Angiotensin II (Ang II) is metabolized from N-terminal by aminopeptidases and from C-terminal by Ang converting enzyme (ACE) to generate several truncated angiotensin peptides (Angs). The truncated Angs have different... -
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- Survival of Cancer Patients in Northeast China: Analysis of Sampled Cancers from Population-Based Cancer Registries
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Li Y, Yu L, Na J, Li S, Liu L, Mu H, Bi X, An X, Li X, Dong W, Pan G
- KMID: 2394829
- Cancer Res Treat.
- 2017 Oct;49(4):1106-1113.
- doi: 10.4143/crt.2016.613
PURPOSE: The cancer survival was characterized by following up sampled subgroups of cancer cases from three population-based cancer registries in Northeast China. MATERIALS AND METHODS: Survival analysis was used to analyze... -
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- Erdheim-Chester Disease with Emperipolesis: A Unique Case Involving the Heart
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Zhu P, Li N, Yu L, Miranda MN, Wang G, Duan Y
- KMID: 2378129
- Cancer Res Treat.
- 2017 Apr;49(2):553-558.
- doi: 10.4143/crt.2016.078
Histiocytosis is an uncommon disease characterized by excessive accumulation of histiocytes. Here, we report a rare case of non-Langerhans-cell histiocytosis in a 51-year-old woman who presented with severe symptoms of... -
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- Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3
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Li D, Yan Y, Yu L, Duan Y
- KMID: 2351672
- Biomol Ther.
- 2016 Sep;24(5):489-494.
- doi: 10.4062/biomolther.2016.006
Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its... -
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- siRNA-Mediated Suppression of Synuclein gamma Inhibits MDA-MB-231 Cell Migration and Proliferation by Downregulating the Phosphorylation of AKT and ERK
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He J, Xie N, Yang J, Guan H, Chen W, Wu H, Yuan Z, Wang K, Li G, Sun J, Yu L
- KMID: 2286346
- J Breast Cancer.
- 2014 Sep;17(3):200-206.
- doi: 10.4048/jbc.2014.17.3.200
PURPOSE: Synuclein-gamma (SNCG), which was initially identified as breast cancer specific gene 1, is highly expressed in advanced breast cancers, but not in normal or benign breast tissue. This study... -
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- Coronary Flow Reserve in the Remote Myocardium Predicts Left Ventricular Remodeling Following Acute Myocardial Infarction
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Cheng R, Wei G, Yu L, Su Z, Wei L, Bai X, Tian J, Li X
- KMID: 2130813
- Yonsei Med J.
- 2014 Jul;55(4):904-911.
- doi: 10.3349/ymj.2014.55.4.904
PURPOSE: Coronary flow reserve (CFR) in the non-infarcted myocardium is often impaired following acute myocardial infarction (AMI). However, the clinical significance of CFR in the non-infarcted myocardium is not fully... -
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- A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells
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Di X, Andrews DM, Tucker CJ, Yu L, Moore AB, Zheng X, Castro L, Hermon T, Xiao H, Dixon D
- KMID: 1365905
- Exp Mol Med.
- 2012 Apr;44(4):281-292.
- doi: 10.3858/emm.2012.44.4.024
Previously, we found that high doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. In this study, using microarray analysis and Ingenuity Pathways Analysis(TM), we identified... -
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- Coexisting with Clonal Evolution and BCR-ABL Mutant in CML Patients Treated with Second-generation Tyrosine Kinase Inhibitors Predict the Discrepancy of in vitro Drug Sensitivity
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Ahn JS, Kim YK, Lee SR, Yu L, Yang DH, Cho SH, Shim HJ, Bae WK, Lee JJ, Chung IJ, Shin MG, Kim HJ
- KMID: 2165975
- Cancer Res Treat.
- 2010 Mar;42(1):37-41.
PURPOSE: Second-generation tyrosine kinase inhibitors (second TKIs) such as nilotinib and dasatinib control the activity of most ABL kinase domain mutations observed in patients with imatinib resistance. Although in vitro... -
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