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Azidothymidine Downregulates Insulin-Like Growth Factor-1 Induced Lipogenesis by Suppressing Mitochondrial Biogenesis and Mitophagy in Immortalized Human Sebocytes

Yoo JG, Li XM, Lee JK, Park S, Hong D, Jung KE, Lee Y, Seo YJ, Kim CD, Shin JM, Choi CW

Background: Increased sebum secretion is considered the main causative factor in the pathogenesis of acne. There is an unmet pharmacological need for a novel drug that can control sebum production...
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Prognostic Value of TP53 Mutation for Transcatheter Arterial Chemoembolization Failure/Refractoriness in HBV-Related Advanced Hepatocellular Carcinoma

Xue M, Wu Y, Fan W, Guo J, Wei J, Wang H, Tan J, Wang Y, Yao W, Zhao Y, Li J

Purpose This study aimed to investigate the clinicopathologic features and mutational landscape of patients with hepatitis B virus (HBV)–related advanced hepatocellular carcinomas (HCC) undergoing transcatheter arterial chemoembolization (TACE). Materials and Methods From January...
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Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes

Wang C, Hwang YL, Li XM, Kim SJ, Zhu MJ, Lee JH, Jiang RH, Kim CD

BACKGROUND: Sebocytes are the major cells of sebaceous gland. The essential role of sebocytes is the production of sebum, a specific lipid mixture, that covers the body surface and provides...
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Inhibition of Poly(I:C)-Induced Inflammation by Salvianolic Acid A in Skin Keratinocytes

Zhang QL, Jiang RH, Li XM, Ko JW, Kim CD, Zhu MJ, Lee JH

BACKGROUND: Skin keratinocytes participate actively in inducing immune responses when external pathogens are introduced, thereby contributing to elimination of pathogens. However, in condition where the excessive inflammation is occurred, chronic...
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Technical Report: A Cost-Effective, Easily Available Tofu Model for Training Residents in Ultrasound-Guided Fine Needle Thyroid Nodule Targeting Punctures

Zhang YF, Li H, Wang XM

OBJECTIVE: To establish a cost-effective and easily available phantom for training residents in ultrasound-guided fine needle thyroid nodule targeting punctures. MATERIALS AND METHODS: Tofu, drinking straws filled with coupling gel, a...
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Signal Detection of Imipenem Compared to Other Drugs from Korea Adverse Event Reporting System Database

Park K, Soukavong , Kim J, Kwon KE, Jin XM, Lee J, Yang BR, Park BJ

PURPOSE: To detect signals of adverse drug events after imipenem treatment using the Korea Institute of Drug Safety & Risk Management-Korea adverse event reporting system database (KIDS-KD). MATERIALS AND METHODS: We...
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Signal Detection of Adverse Drug Reaction of Amoxicillin Using the Korea Adverse Event Reporting System Database

Soukavong , Kim J, Park K, Yang BR, Lee J, Jin XM, Park BJ

We conducted pharmacovigilance data mining for a β-lactam antibiotics, amoxicillin, and compare the adverse events (AEs) with the drug labels of 9 countries including Korea, USA, UK, Japan, Germany, Swiss,...
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Utilization Patterns of Disease-Modifying Antirheumatic Drugs in Elderly Rheumatoid Arthritis Patients

Jin XM, Lee J, Choi NK, Seong JM, Shin JY, Kim YJ, Kim MS, Yang BR, Park BJ

This study was conducted to investigate disease-modifying antirheumatic drug (DMARD) utilization in Korean elderly patients with rheumatoid arthritis (RA). We used data from January 1, 2005 to June 30, 2006...
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Stimulation of keratinocyte differentiation by extract of combined medicinal plant

Li XM, Choi DK, Lim SK, Ahn IS, Kim DI, Piao YJ, Kim CD, Lee JH

Skin is the outermost organ and acts as a barrier between the organism and environment. Skin protects the organism from environmental insults, such as chemicals, pathogens, and UV light. Much...
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Bronchopulmonary Infection of Lophomonas blattarum: A Case and Literature Review

Xue J, Li YL, Yu XM, Li DK, Liu MF, Qiu JF, Xue JJ

Human infections with Lophomonas blattarum are rare. However, the majority of the infections occurred in China, 94.4% (136 cases) of all cases in the world. This infection is difficult to...
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Generation and Immunity Testing of a Recombinant Adenovirus Expressing NcSRS2-NcGRA7 Fusion Protein of Bovine Neospora caninum

Jia LJ, Zhang SF, Qian NC, Xuan XN, Yu LZ, Zhang XM, Liu MM

Neospora caninum is the etiologic agent of bovine neosporosis, which affects the reproductive performance of cattle worldwide. The transmembrane protein, NcSRS2, and dense-granule protein, NcGRA7, were identified as protective antigens...
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Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates

Lee YJ, Jeong JK, Seol JW, Xue M, Jackson C, Park SY

  • KMID: 2154228
  • Exp Mol Med.
  • 2013 Feb;45(2):e9.
Activated protein C (APC) is a cytoprotective anticoagulant that can promote cutaneous healing. We examined the effect of APC on viability and differentiation of the osteoblastic line, MG63, in the...
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Comparison of the Safety of Seven Iodinated Contrast Media

Seong JM, Choi NK, Lee J, Chang Y, Kim YJ, Yang BR, Jin XM, Kim JY, Park BJ

We aimed to determine the characteristic adverse events (AEs) of iodinated contrast media (IOCM) and to compare the safety profiles of different IOCM. This study used the database of AEs...
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Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation

Moon MH, Jeong JK, Seo JS, Seol JW, Lee YJ, Xue M, Jackson CJ, Park SY

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, is one of the most promising candidates for cancer therapeutics. However, many osteosarcomas are resistant...
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Frequency of Extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase Genes in Escherichia coli and Klebsiella pneumoniae over a Three-year Period in a University Hospital in Korea

Li XM, Jang SJ, Bae IK, Park G, Kim YS, Shin JH, Moon DS, Park YJ

BACKGROUND: The aim of this study was to determine the yearly prevalence and genotype distribution of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae collected over a 3-yr period in...
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A Strain of Nocardia cyriacigeorgica Isolated from a Patient with Pulmonary Infection

Oh HR, Kim YS, Jang SJ, Li XM, Kim WY, Park G, Moon DS, Park YJ

Nocardia cyriacigeorgica is an aerobic gram-positive rod that has mostly been reported as an opportunistic pathogen. Since molecular methodologies were introduced to identify species, infections caused by N. cyriacigeorgica have...
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Epidemiological Investigation of an Outbreak of Escherichia coli Infections in Neonatal Intensive Care Unit of a University Hospital

Oh HR, Moon DS, Jang SJ, Li XM, Kim DM, Park SG, Park G, Park YJ

BACKGROUND: In July 2007, three neonates in the neonatal intensive care unit (NICU) of Chosun University Hospital expired due to Escherichia coli sepsis. An E. coli outbreak was suspected. METHODS: To...
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Preliminary Results for the Treatment of a Pain-Causing Osteoporotic Vertebral Compression Fracture with a Sky Bone Expander

Liu JB, Tang XM, Xu NW, Bao HT

OBJECTIVE: Vertebral compression fractures (VCFs) are common complications of osteoporosis. The expansion of VCFs with a Sky Bone Expander is a new procedure which improves kyphotic deformities and decreases pain...
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Prevalence of Carbapenemase and Integrase Genes in Imipenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa Collected over Several Years in a University Hospital

Oh HR, Jang SJ, Yu FN, Park G, Li XM, Shin SH, Kim WY, Moon DS, Park YJ

  • KMID: 2300457
  • Korean J Clin Microbiol.
  • 2007 Oct;10(2):128-134.
BACKGROUND: The incidence of infections with imipenem- resistant Acinetobacter baumannii (IRAB) and Pseudomonas aeruginosa (IRPA) is increasing worldwide, and recent molecular studies indicate that the prevalence of carbapenemases is increasing...
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