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Coronary Flow Reserve in the Remote Myocardium Predicts Left Ventricular Remodeling Following Acute Myocardial Infarction

Cheng R, Wei G, Yu L, Su Z, Wei L, Bai X, Tian J, Li X

PURPOSE: Coronary flow reserve (CFR) in the non-infarcted myocardium is often impaired following acute myocardial infarction (AMI). However, the clinical significance of CFR in the non-infarcted myocardium is not fully...
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Urinary Biomarkers for the Noninvasive Detection of Gastric Cancer

Li D, Yan L, Lin F, Yuan X, Yang X, Yang X, Wei L, Yang Y, Lu Y

Gastric cancer (GC) is associated with high morbidity and mortality rates. Thus, early diagnosis is important to improve disease prognosis. Endoscopic assessment represents the most reliable imaging method for GC...
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Sciatic nerve leachate of cattle causes neuronal differentiation of PC12 cells via ERK1/2 signaling pathway

Zhang Z, Liu Y, Zhu X, Wei L, Zhu J, Shi K, Wang G, Pan L

Previous studies have shown that the sciatic nerve has neurotrophic activity, and nerve regeneration, differentiation, and axon outgrowth can be modulated by different sciatic nerve preparations. However, numerous animals may...
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BMP‑6 Attenuates Oxygen and Glucose Deprivation-Induced Apoptosis in Human Neural Stem Cells through Inhibiting p38 MAPK Signaling Pathway

Wang L, Chen Y, Wei L, He J

Background and Objectives: Neural stem cells (NSCs) remain in the mammalian brain throughout life and provide a novel therapeutic strategy for central nervous system (CNS) injury. Bone morphogenetic protein-6 (BMP-6)...
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Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction

Wei L, Singh R, Ghoshal UC

  • KMID: 2531182
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):357-375.
  • doi: 10.5056/jnm22008
Disorders of gut-brain interaction (DGBIs) are common conditions in community and clinical practice. As specialized enteroendocrine cells, enterochromaffin (EC) cells produce up to 95% of total body serotonin and coordinate...
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Coronary Flow Reserve in Non-Infarcted Myocardium Predicts Long-Term Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention

Cheng R, Zhu X, Li Y, Bai X, Xue L, Wei L

PURPOSE: Coronary flow reserve (CFR) is recognized as an indicator of myocardial perfusion. The aim of this study was to assess the relationship between CFR in the non-infarcted myocardium and...
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Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders

Singh R, Zogg H, Wei L, Bartlett A, Ghoshal UC, Rajender S, Ro S

  • KMID: 2510059
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):19-34.
  • doi: 10.5056/jnm20149
Of all microorganisms in the human body, the largest and most complex population resides in the gastrointestinal (GI) tract. The gut microbiota continuously adapts to the host environment and serves...
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Developmental Exposure to Di-(2-ethylhexyl) Phthalate Induces Cerebellar Granule Cell Apoptosis via the PI3K/AKT Signaling Pathway

Fu Y, Dong J, Wang J, You M, Wei L, Fu H, Wang Y, Chen J

Di-(2-ethylhexyl) phthalate (DEHP) is an ubiquitous environmental contaminant because of its extensive use in plastics and its persistence. As an environmental endocrine disruptor, it is suspected to interfere with neurodevelopment...
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Comparative Study between ZOOMit and Conventional Intravoxel Incoherent Motion MRI for Assessing Parotid Gland Abnormalities in Patients with Early- or Mid-Stage Sjögren’s Syndrome

Zhou QQ, Zhang W, Yu YS, Li HY, Wei L, Li XS, He ZZ, Zhang H

Objective: To compare the reproducibility and performance of quantitative metrics between ZOOMit and conventional intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) in the diagnosis of early- and mid-stage Sjögren’s...
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An Intratracheal Challenge Murine Model of Asthma: Can Bronchial Inflammation Affect the Nose?

Xie J, Xi Y, Zhang Q, Chen G, Wei L, Lai K, Zhong N

PURPOSE: Extensive data support the influence of the upper airway on lower airway inflammation and pathophysiology in allergic disease. However, few studies have focused on allergic inflammation in the nose...
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Thrombus Enhancement Sign for Differentiation of Embolism and Arteriosclerosis-Related Acute Large Vessel Occlusion

Zhang Y, He G, Lu J, Miao G, Liang D, Wang J, Wei L, Deng J, Zhu Y

Background and Purpose To evaluate whether the thrombus enhancement sign (TES) can be used to differentiate embolic large vessel occlusion (LVO) from in situ intracranial atherosclerotic stenosis (ICAS)-related LVO in...
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Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir

Hu C, Chen Z, Zhao W, Wei L, Zheng Y, He C, Zeng Y, Yin B

  • KMID: 2170650
  • Biomol Ther.
  • 2014 Mar;22(2):114-121.
Refractoriness of acute myeloid leukemia (AML) cells to chemotherapeutics represents a major clinical barrier. Suicide gene therapy for cancer has been attractive but with limited clinical efficacy. In this study,...
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Recommendations on management of gynecological malignancies during the COVID-19 pandemic: perspectives from Chinese gynecological oncologists

Wang Y, Zhang S, Wei L, Lin Z, Wang X, Wang J, Hua K, Cui M, Wang J, Wang S, Di W, Wang Y, An R, Xi M, Guo R, Zhou Q, Xie X, Xue F

The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 has rapidly spread globally. Cancer patients are at a higher risk of being infected...
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