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Diagnosis of an indistinct Leydig cell tumor by positron emission tomography-computed tomography

Kong J, Park YM, Choi YS, Cho S, Lee BS, Park JH

A 51-year-old perimenopausal female patient presented with hirsutism and voice thickening which was started approximately one and a half years ago. Her initial hormone assay revealed elevated plasma testosterone, 5a-dihydrotestosterone,...
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Virilizing Adrenocortical Carcinoma Advancing to Central Precocious Puberty after Surgery

Kim MS, Yang EJ, Cho DH, Hwang PH, Lee DY

Adrenocortical carcinoma (ACC) in pediatric and adolescent patients is rare, and it is associated with various clinical symptoms. We introduce the case of an 8-year-old boy with ACC who presented...
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Successful term pregnancies after laparoscopic excision of poorly differentiated Sertoli-Leydig cell tumor of the ovary

Gowri V, Koliyadan , Al Hamdani A, Al Kindy N

Ovarian Sertoli-Leydig cell tumors are rare sex cord-stromal tumors, accounting for less than 1% of ovarian tumors. Majority of these tumors are benign and unilateral, only 3-5% are bilateral. These...
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Adrenocortical tumors in children 18 years old and younger

Cho MJ, Kim DY, Kim SC, Kim TH, Kim IK

PURPOSE: Pediatric adrenocortical tumors (ACTs) are rare. We reviewed findings in 8 children, 18 years of age or younger, diagnosed with ACT in our institution over the past 15 years. METHODS:...
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A Case of adrenocortical oncocytoma Presenting with Peripheral Precocious Puberty

Oh SH, Jung CW, Lee J, Lee BH, Kim DY, No DY, Yoo SH, Choi JH, Yoo HW

Adrenocortical oncocytoma is a rare adrenal gland tumor, and in most cases, benign and non-functioning. Functional adrenocortical oncocytoma has only been reported in eleven cases worldwide, including three children. These...
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A Case of Adrenocortical Carcinoma Secreting Cortisol and Aldosterone

Ha J, Kim MK, Cha YJ, Kim SK, Yun GY, Rhee K, Park JS, Cho ES, Ahn CW, Park JS

Adrenocortical carcinomas are rare and frequently aggressive tumors that may be functional (hormone-secreting) and may cause Cushing's syndrome or virilization, or non-functional and manifest as an abdominal mass. This paper...
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A Adrenocortical Oncocytoma in a 10-year-old Girl Presenting with Virilization

Eom TM, Kim MK, Lee SH, Chung WY, Park JK, Jung SJ, Shin JH

  • KMID: 2049284
  • Clin Pediatr Hematol Oncol.
  • 2012 Oct;19(2):128-131.
Adrenocortical oncocytoma is a rare epithelial tumor only described in adults and in most cases, benign and non-functioning. Histologically characterized by cells with eosinophilic granular cytoplasm and ultra-structurally by the...
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A sclerosing stromal tumor of the ovary with masculinization in a premenarchal girl

Park SM, Kim YN, Woo YJ, Choi HS, Lee JS, Heo SH, Kim CJ

A sclerosing stromal tumor of the ovary is an extremely rare benign tumor; it usually is found during the second and third decades of life. Patients present with pelvic pain...
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Virilizing Adrenocortical Oncocytoma in a Child: A Case Report

Lim YJ, Lee SM, Shin JH, Koh HC, Lee YH

Functioning adrenocortical oncocytomas are extremely rare and most reported patients are 40-60 yr of age. To our knowledge, only 2 cases of functioning adrenocortical oncocytomas have been reported in childhood....
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A case of turner mosaicism with virilization

Im ES, Choo CW, Kim SW, Sung JY, Park JW, Kim HR, Jee BC

  • KMID: 1474973
  • Korean J Obstet Gynecol.
  • 2009 Jun;52(6):671-675.
A 17-year-old girl presented with primary amenorrhea, short stature, and clitomegaly. Her karyotype showed Turner mosaicism of 45,X/46,XY,idic(Y)(q11.23)del(Y)(q11.23). Laparoscopic bilateral gonadectomy was performed and there was testicular tissue in left...
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Ovarian Thecoma with Virilizing Manifestations

Lee MH, Moon YJ, Ha CW, Hoh JK

A 29-year-old woman presented with secondary amenorrhea, primary infertility, and virilization, which had developed over the past 2 years was suspected to have a virilizing tumor at her left ovary....
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A Case of Adrenocortical Tumor in a 16-Month-Old Boy Presenting with Virilization

Kwak MJ, Hyun HS, Kim SJ, Paik KH, Jin DK

  • KMID: 2321965
  • J Korean Soc Pediatr Endocrinol.
  • 2008 Jun;13(1):110-116.
A 16-month-old boy had signs of virilization such as penile enlargement and pubic hair since 13 months of age. Hormone evaluation indicated increased levels of 17-OH-progesterone, dehydroepiandrosterone- sulfate (DHEA-S) and...
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Therapy with Human Chorionic Gonadotropin and Human Menopausal Gonadotropin in Men with Hypogonadotropic Hypogonadism

Kim SD, Kim MK, Park JK

  • KMID: 2226571
  • Korean J Androl.
  • 2008 Jun;26(2):69-73.
PURPOSE: Hypogonadotropic hypogonadism (HH) is an uncommon cause of virilization and male infertility. We evaluated the effect of the combination therapy with human chorionic gonadotropin (hCG) and human menopausal gonadotropin...
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A case of Sertoli-Leydig cell tumor with mature cystic teratoma in a postmenopausal woman

Kim SY, Shin MY, Kang JH, Seo KY, Ju IS, Kim JW, Kim KR

  • KMID: 2273537
  • Korean J Obstet Gynecol.
  • 2008 Nov;51(11):1368-1372.
Sertoli-Leydig cell tumor is a gonadal tumor of the sex cord-stromal type. It is a rare tumor comprising 0.5% of all ovarian tumors and is best known for their frequent...
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Two Cases of Simple Virilizing Congenital Adrenal Hyperplasia with Compound Heterozygous Mutations of CYP21 Gene

Kim KS, Choi YS, Bai YS, Rha SY, Jo YS, Shong M

Steroid 21-hydroxylase deficiency is the most frequent cause of congenital adrenal hyperplasia (CAH), which is an inherited inability to synthesize cortisol. Actually, CAH is caused by mutations in the CYP21...
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A case of 5 alpha reductase deficiency

Jang MJ, Oh SY, Choi SE, Oh HK, Kim DY, Choi YS

  • KMID: 1870367
  • Korean J Obstet Gynecol.
  • 2007 Mar;50(3):550-554.
5 alpha-reductase deficiency is a rare autosomal recessive disorder caused by mutations in the SRD5A2-gene, resulting in absent or diminished dihydrotestosterone (DHT) formation and, hence, in an underdevelopment of the...
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Clinical Review of the Pediatric Primary Adrenocortical Tumors

Chai YJ, Moon SB, Jung SE, Lee SC, Park KW

  • KMID: 2328744
  • J Korean Assoc Pediatr Surg.
  • 2007 Dec;13(2):162-168.
Adrenocortical tumors are very rare in children and the clinical course is not clearly understood. The aim of this study is to review the clinical characteristics and courses of pediatric...
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Long-term Follow up of Congenital Adrenal Hyperplasia Patients with Hyponatremia

Song JH, Lee KH, Kim SD, Cho BS

Congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency is an autosomal recessive disease, which leads to cortisol and aldosterone deficiency and hyperandrogenism. Typical medical treatment includes oral glucocorticoid and mineralocorticoid...
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Three Cases of Sertoli-Leydig Cell Tumor

Park JW, Yim KR, Kim YM, Kim JY

  • KMID: 2013173
  • Korean J Obstet Gynecol.
  • 2006 Mar;49(3):682-689.
Sertoli-Leydig cell tumors of the ovary are one of the sex cord-stromal tumors. They are very rare, account for less than 0.5% of all ovarian tumor. These tumors are almost...
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A Case of Adrenocortical Carcinoma showing Variable Cortisol Production during the Clinical Course

Ku YH, Choi HJ, Kim JT, Yoon JW, Lee EK, Cho HY, Kang MY, Lee JS, Cho YM, Kim SY

Patients with adrenocortical carcinoma (ACC) present with evidence of excessive adrenal steroid hormone in approximately 60% of cases, in which rapidly progressing Cushing's syndrome with or without virilization is the...
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