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Change of voltage-gated potassium channel 1.7 expressions in monocrotaline-induced pulmonary arterial hypertension rat model

Lee H, Kim KC, Hong YM

PURPOSE: Abnormal potassium channels expression affects vessel function, including vascular tone and proliferation rate. Diverse potassium channels, including voltage-gated potassium (Kv) channels, are involved in pathological changes of pulmonary arterial...
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Microarray Analysis in Pulmonary Hypertensive Rat Heart after Simvastatin Treatment

Kim YK, Kim KC, Hong YM

OBJECTIVES: Simvastatin has been reported to attenuate the development of pulmonary hypertension through increased apoptosis as well as reduced proliferation of smooth muscle cells in obstructive vascular lesions. Microarray experiment...
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Antihypertensive Treatment in Severe Aortic Stenosis

Kang TS, Park S

Previously, antihypertensive treatment in severe aortic stenosis was considered a relative contraindication. However, recent studies have shown that antihypertensive treatment may be safe and even beneficial in terms of reducing...
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How Long Can the Next Intervention Be Delayed after Balloon Dilatation of Homograft in the Pulmonary Position?

Jeong HI, Song J, Choi EY, Kim SH, Huh J, Kang IS, Yang JH, Jun TG

BACKGROUND AND OBJECTIVES: We investigated the effectiveness of balloon dilatation of homograft conduits in the pulmonary position in delaying surgical replacement. SUBJECTS AND METHODS: We reviewed the medical records of patients...
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Redefining Effusive-Constrictive Pericarditis with Echocardiography

van der Bijl P, Herbst P, Doubell AF

BACKGROUND: Effusive-constrictive pericarditis (ECP) is traditionally diagnosed by using the expensive and invasive technique of direct pressure measurements in the pericardial space and the right atrium. The aim of this...
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The effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline-induced right ventricular failure

Bae HK, Lee H, Kim KC, Hong YM

PURPOSE: Pulmonary arterial hypertension (PAH) leads to right ventricular failure (RVF) as well as an increase in pulmonary vascular resistance. Our purpose was to study the effect of sildenafil on...
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Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal Stem Cell-Conditioned Medium on Pulmonary Arterial Hypertension in Rats

Lee JC, Cha CI, Kim DS, Choe SY

BACKGROUND: Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) may have multiple therapeutic applications for cell based therapy including the treatment of pulmonary artery hypertension (PAH). As low survival rates...
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Effect of anemia correction on left ventricular structure and filling pressure in anemic patients without overt heart disease

Cho IJ, Mun YC, Kwon KH, Shin GJ

  • KMID: 2070108
  • Korean J Intern Med.
  • 2014 Jul;29(4):445-453.
BACKGROUND/AIMS: There are few data on the effects of low hemoglobin levels on the left ventricle (LV) in patients without heart disease. The objective of this study was to document...
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Nitric Oxide Synthase Inhibition Attenuates Cardiac Response to Hemodilution with Viscogenic Plasma Expander

Chatpun S, Cabrales P

BACKGROUND AND OBJECTIVES: Increased vascular wall shear stress by elevated plasma viscosity significantly enhances the endothelial nitric oxide synthase (eNOS) activity during an acute isovolemic hemodilution. Also the modulation of...
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Utility of Global Strain by Two-Dimensional and Three-Dimensional Speckle Tracking for Assessing Left Ventricular Diastolic Function: Comparison with Pressure Wire Analysis

Shin SH, Park SD, Woo SI, Kim DH, Park KS, Kwan J

BACKGROUND AND OBJECTIVES: We evaluated the utility of two-dimensional (2D) and three-dimensional (3D) left ventricular (LV) global myocardial deformity parameters for assessing LV diastolic function by comparing invasive measures of...
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Percutaneous Pulmonary Valve Implantation

Lee YS, Lee HD

Pulmonary regurgitation (PR) is a frequent sequelae after repair of tetralogy of Fallot, pulmonary atresia, truncus arteriosus, Rastelli and Ross operation. Due to patient growth and conduit degeneration, these conduits...
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Effectiveness and Safety of Percutaneous Transcatheter Implantation of Pulmonary Arterial Stent in Congenital Heart Disease

Ko HK, Kim YH, Yu JJ, Ko JK, Park IS, Seo DM, Yun TJ, Park JJ, Jang WS

BACKGROUND AND OBJECTIVES: Pulmonary arterial stenosis is a relatively common complication after corrective operation of congenital heart disease. Unilateral stenosis of pulmonary arteries could result in decrease perfusion of affected...
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Vasorelaxing Activity of Ulmus davidiana Ethanol Extracts in Rats: Activation of Endothelial Nitric Oxide Synthase

Cho EJ, Park MS, Kim SS, Kang G, Choi S, Lee YR, Chang SJ, Lee KH, Lee SD, Park JB, Jeon BH

Ulmus davidiana var. japonica Rehder (Urticales: Ulmaceae) (UD) is a tree widespread in northeast Asia. It is traditionally used for anticancer and anti-inflammatory therapy. The present study investigated the effect...
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Changes of Pulmonary Pathology and Gene Expressions After Simvastatin Treatment in the Monocrotaline-Induced Pulmonary Hypertension Rat Model

Lee YH, Kim KC, Cho MS, Hong YM

BACKGROUND AND OBJECTIVES: Simvastatin's properties are suggestive of a potential pathophysiologic role in pulmonary hypertension. The objectives of this study were to investigate changes of pulmonary pathology and gene expressions,...
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Simvastatin, Sildenafil and Their Combination in Monocrotaline Induced Pulmonary Arterial Hypertension

Lee DS, Kim YK, Jung YW

BACKGROUND AND OBJECTIVES: Pulmonary arterial hypertension (PAH) is a life threatening disease characterized by progressive pulmonary arterial occlusion which may ultimately result in death. Currently, the available treatments are diverse,...
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Effect of propofol on cardiac function and gene expression after ischemic-reperfusion in isolated rat heart

Kim YJ, Lim HJ, Choi SU

BACKGROUND: The aim of this study was to examine the cardiac function and transcriptional response of the heart to propofol after ischemia-reperfusion. METHODS: Rat hearts were Langendorff-perfused using the modified...
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The changes in signal-averaged electrocardiogram after surgical correction of congenital heart disease

Kim YH, Choi HJ, Kim GJ, Cho JY, Hyun MC, Lee SB

PURPOSE: To analyze abnormal ventricular activation in childhood congenital heart disease induced by postoperative changes in ventricular volume and pressure and ventricular scar formation using signal-averaged electrocardiography (SAECG). METHODS: Fifty-two...
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A case of displaced pulmonary artery catheter into hepatic vein in mitral insufficiency patient: A case report

Chun DH, Chung KH, Lee JY, Song JE, Kim JY, Lee JH, Park C

A 47-year-old woman was scheduled for mitral valvoplasty. Before induction of anesthesia, a pulmonary artery catheter (PAC) was placed via right internal jugular vein. Central venous pressure or right atrial...
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A case of persistent pulmonary hypertension of the newborn: Treatment with inhaled iloprost

Jang YY, Park HJ

We report a case of a full-term neonate with persistent pulmonary hypertension who developed asphyxia after birth and was treated with iloprost. The neonate had persistent hypoxia and did not...
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ICP Trend in Massive ICH Patients After Decompressive Craniectomy

Lee CH, Yoo DS, Huh PW, Cho KS, Kang SG, Park CK

  • KMID: 1470169
  • Korean J Cerebrovasc Surg.
  • 2009 Sep;11(3):99-105.
OBJECTIVE: Massive intracerebral hemorrhage (ICH) is devastating neurosurgical disease. Decompression surgery has been performed to manage the uncontrolled increased intracranial pressure and good clinical result has been reported. Authors analyze...
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