- Forensic science meets clinical pharmacology: pharmacokinetic model based estimation of alcohol concentration of a defendant as requested by a local prosecutor's office
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Lim HS, Soung JH, Bae KS
- KMID: 2411412
- Transl Clin Pharmacol.
- 2017 Mar;25(1):5-9.
- doi: 10.12793/tcp.2017.25.1.5
Drunk driving is a serious social problem. We estimated the blood alcohol concentration of a defendant on the request of local prosecutor's office in Korea. Based on the defendant's history,... -
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- Development of an automated appendix generation system (ARGUS) for clinical study reports
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Jang D, Han S, Yim DS
- KMID: 2411417
- Transl Clin Pharmacol.
- 2017 Mar;25(1):34-42.
- doi: 10.12793/tcp.2017.25.1.34
Data handling and tabulation are a time-consuming job when writing appendices for clinical study reports. The authors have developed an automated appendix generation system (ARGUS) conforming to the CDISC/SDTM standard... -
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- Tutorial for beginners: the concept of clearance explained using the example of a vacuum cleaner
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Yim DS
- KMID: 2411411
- Transl Clin Pharmacol.
- 2017 Mar;25(1):1-4.
- doi: 10.12793/tcp.2017.25.1.1
Clearance is a key concept in pharmacokinetics, but it is not easy to understand for beginners. This tutorial aims to help beginners by using the analogy of a vacuum cleaner... -
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- Decreased potency of fimasartan in liver cirrhosis was quantified using mixed-effects analysis
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Kim CO, Jeon S, Han S, Hong T, Park MS, Yoon YR, Yim DS
- KMID: 2411418
- Transl Clin Pharmacol.
- 2017 Mar;25(1):43-51.
- doi: 10.12793/tcp.2017.25.1.43
Fimasartan is a nonpeptide angiotensin II receptor blocker. In a previous study that compared the pharmacokinetics (PK) of fimasartan between patients with hepatic impairment (cirrhosis) and healthy subjects, the exposure... -
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- Comparative pharmacokinetic and tolerability evaluation of two simvastatin 20 mg formulations in healthy Korean male volunteers
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Moon SJ, Lee S, Jang K, Yu KS, Yim SV, Kim BH
- KMID: 2411413
- Transl Clin Pharmacol.
- 2017 Mar;25(1):10-14.
- doi: 10.12793/tcp.2017.25.1.10
Simvastatin is used to reduce plasma cholesterol by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and is primarily used to treat hypercholesterolemia. This study was conducted to assess the bioequivalence between... -
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- Validated UPLC-MS/MS method for the determination of tadalafil in human plasma and its application to a pharmacokinetic study
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Kim KY, Nam M, Kwon HJ, Kim KH, Kang SH, Kim SI, Kim CW, Cho SH
- KMID: 2411415
- Transl Clin Pharmacol.
- 2017 Mar;25(1):21-27.
- doi: 10.12793/tcp.2017.25.1.21
A simple, rapid, and reliable UPLC-MS/MS method was developed and validated for the determination of tadalafil in human plasma. The plasma samples were deproteinized with acetonitrile. Chromatographic separation was performed... -
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- Hydrochlorothiazide does not increase furosemide's effects in end-stage renal disease
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Huh W, Oh HY, Han JS, Jang IJ, Yim DS
- KMID: 2411416
- Transl Clin Pharmacol.
- 2017 Mar;25(1):28-33.
- doi: 10.12793/tcp.2017.25.1.28
Diuretic therapy for the treatment of edema in patients with end-stage renal disease (ESRD) is unsatisfactory, and a combination of thiazide and loop diuretics may produce better clinical effects. To... -
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- Enhancement of skin permeation of vitamin C using vibrating microneedles
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Lee CA, Baek JS, Kwag DG, Lee HJ, Park J, Cho CW
- KMID: 2411414
- Transl Clin Pharmacol.
- 2017 Mar;25(1):15-20.
- doi: 10.12793/tcp.2017.25.1.15
This study was performed to evaluate the use of vibrating microneedles for the transdermal delivery of vitamin C. The microneedles were designed to vibrate at three levels of intensity. In... -
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