- Clinical pharmacologic aspects of immune checkpoint inhibitors in cancer therapy
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Kim KP, Jung H
- KMID: 2383594
- Transl Clin Pharmacol.
- 2016 Mar;24(1):7-12.
- doi: 10.12793/tcp.2016.24.1.7
During the past two years, three immune checkpoint inhibitors, ipilimumab, nivolumab and pembrolizumab, have been approved and revolutionized cancer immunotherapy. Translational and clinical pharmacology of these agents have contributed in... -
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- How a VOICE for clinical pharmacology turns into a RECIPE for its development
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Aronson JK
- KMID: 2383593
- Transl Clin Pharmacol.
- 2016 Mar;24(1):1-6.
- doi: 10.12793/tcp.2016.24.1.1
Pharmacology is the study of the actions of synthetic or semisynthetic chemicals or naturally occurring substances on molecules, cells, tissues, and living organisms, as seen in physiological and pathological systems,... -
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- Brief introduction to current pharmacogenomics research tools
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Cha EY, Jeong HE, Kim WY, Shin HJ, Kim HS, Shin JG
- KMID: 2383595
- Transl Clin Pharmacol.
- 2016 Mar;24(1):13-21.
- doi: 10.12793/tcp.2016.24.1.13
There is increasing interest in the application of personalized therapy to healthcare to increase the effectiveness of and reduce the adverse reactions to treatment. Pharmacogenomics is a core element in... -
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- Mixed?effects analysis of increased rosuvastatin absorption by coadministered telmisartan
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Park WS, Jang D, Han S, Yim DS
- KMID: 2383600
- Transl Clin Pharmacol.
- 2016 Mar;24(1):55-62.
- doi: 10.12793/tcp.2016.24.1.55
The Cmax and AUC of rosuvastatin increase when it is coadministered with telmisartan. The aim of this study was to explore which of the pharmacokinetic (PK) parameters of rosuvastatin are... -
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- HPLC-UV method for the simultaneous determinations of ascorbic acid and dehydroascorbic acid in human plasma
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Kim Y, Kim MG
- KMID: 2383598
- Transl Clin Pharmacol.
- 2016 Mar;24(1):37-42.
- doi: 10.12793/tcp.2016.24.1.37
A high performance liquid chromatography (HPLC) paired with UV-vis detection method to determine ascorbic acid and its oxidation product, dehydroascorbic acid, in human plasma was developed. Ascorbic acid in human... -
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- Development of a validated liquid chromatography-tandem mass spectrometry assay for the quantification of simvastatin acid, the active metabolite of simvastatin, in human plasma
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Park HJ, Hwang AK, Kim AR, Kim SH, Kim EH, Cho SH, Ghim JL, Choe S, Jung JA, Jin SJ, Bae KS, Lim HS
- KMID: 2383596
- Transl Clin Pharmacol.
- 2016 Mar;24(1):22-29.
- doi: 10.12793/tcp.2016.24.1.22
Simvastatin is a lipid-lowering drug that is metabolized to its active metabolite simvastatin acid (SA). We developed and validated a sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to quantitate SA... -
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- Screening study for genetic polymorphisms affecting pharmacokinetics of simvastatin
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Im S, Kim BH, Lee K, Kwack K, Yim SV
- KMID: 2383599
- Transl Clin Pharmacol.
- 2016 Mar;24(1):43-54.
- doi: 10.12793/tcp.2016.24.1.43
Simvastatin reduces plasma cholesterol by inhibiting HMG-CoA reductase (HMGR) and is widely used in the treatment of hypercholesterolemia. To screening the possible genetic factors affecting the pharmacokinetics (PK) of simvastatin,... -
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- Development and validation of a UPLC-MS/MS method for the quantification of acetaminophen in human plasma and its application to pharmacokinetic studies
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Cha J, Kim BK, Gwon MR, Lee J, Ohk B, Kang WY, Lim MS, Seong SJ, Kim HJ, Lee HW, Yoon YR
- KMID: 2383597
- Transl Clin Pharmacol.
- 2016 Mar;24(1):30-36.
- doi: 10.12793/tcp.2016.24.1.30
We developed an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of acetaminophen concentration in human plasma. Following protein precipitated extraction, the analytes were separated and analyzed using... -
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