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Excretion of Toxoplasma gondii oocysts from Feral Cats in Korea

Ahn KS, Ahn AJ, Park SI, Sohn WM, Shim JH, Shin SS

Sporulated oocysts from the feces of infected cats with Toxoplasma gondii can cause detrimental disease in both humans and animals. To investigate the prevalence of feral cats that excrete T....
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Virus-like Particle Vaccine Containing Toxoplasma gondii Rhoptry Protein 13 Induces Protection against T. gondii ME49 Infection in Mice

Kang HJ, Chu KB, Lee SH, Kim MJ, Park H, Jin H, Quan FS

Toxoplasma gondii can infect humans worldwide, causing serious diseases in pregnant women and immunocompromised individuals. T. gondii rhoptry protein 13 (ROP13) is known as one of the key proteins involved...
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Parasite Infiltration and Apoptosis in Spleen upon Toxoplasma gondii Infection

Lee SH, Chu KB, Quan FS

Toxoplasma gondii infection induces parasite infiltration and apoptosis in the spleen. However, dose-dependent parasite infiltration, apoptosis, body weight alternations and survival in mice remain largely unknown. In this study, mice...
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Tracking acute phase protein response during acute and chronic Toxoplasma gondii infection

Atmaca HT, Gazyagci A, Terzi OS, Dincel GC, Sumer T

Toxoplasmosis is a disease caused by the protozoan Toxoplasma gondii, which occurs worldwide in mammals and birds. Brain is the primary target organ because Toxoplasma gondii is a ubiquitous intracellular...
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Seroprevalence of Toxoplasma gondii among School Children in Pyin Oo Lwin and Naung Cho, Upper Myanmar

Thái TL, Jun H, Park SH, Lê HG, Lee J, Ahn SK, Kang JM, Myint MK, Lin K, Sohn WM, Nam HW, Na BK, Kim TS

Toxoplasma gondii is an apicomplexan parasite that can cause toxoplasmosis in a wide range of warm-blooded animals including humans. In this study, we analyzed seroprevalence of T. gondii among 467...
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Production of Inflammatory Cytokines and Nitric Oxide by Human Mast Cells Incubated with Toxoplasma gondii Lysate

Park EA, Han IH, Kim JH, Park SJ, Ryu JS, Ahn MH

The roles of mast cells in allergic diseases and helminth infections are well known. However, the roles of mast cells in T. gondii infection is poorly understood. This study was...
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Previous Infection with Plasmodium berghei Confers Resistance to Toxoplasma gondii Infection in Mice

Lee DH, Chu KB, Kang HJ, Lee SH, Quan FS

Both Plasmodium spp. and Toxoplasma gondii are important apicomplexan parasites, which infect humans worldwide. Genetic analyses have revealed that 33% of amino acid sequences of inner membrane complex from the...
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Dipenyleneiodonium Induces Growth Inhibition of Toxoplasma gondii through ROS Induction in ARPE-19 Cells

Sun PR, Gao FF, Choi HG, Zhou W, Yuk JM, Kwon J, Lee YH, Cha GH

Based on the reactive oxygen species (ROS) regulatory properties of diphenyleneiodonium (DPI), we investigated the effects of DPI on host-infected T. gondii proliferation and determined specific concentration that inhibit the...
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Rhoptry antigens as Toxoplasma gondii vaccine target

Foroutan M, Ghaffarifar F, Sharifi Z, Dalimi A, Jorjani O

Toxoplasmosis is a cosmopolitan zoonotic infection, caused by a unicellular protozoan parasite known as Toxoplasma gondii that belongs to the phylum Apicomplexa. It is estimated that over one-third of the...
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Tissue Fluid Enzyme-Linked Immunosorbant Assay for Piglets Experimentally Infected with Toxoplasma gondii and Survey on Local and Imported Pork in Korean Retail Meat Markets

Yoo WG, Kim SM, Won EJ, Lee JY, Dai F, Woo HC, Nam HW, Kim TI, Han JH, Kwak D, Cho YS, Kang SW, Kim TS, Zhu XQ, Wang C, Youn H, Hong SJ

To investigate the prevalence of Toxoplasma gondii in pork on the market in Korea, an in-house enzyme-linked immunosorbent assay for tissue fluid (CAU-tf-ELISA) was developed using a soluble extract of...
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Virus-Like Particles Expressing Toxoplasma gondii Rhoptry Protein 18 Induces Better Protection Than Rhoptry Protein 4 against T. gondii Infection

Kang HJ, Lee SH, Chu KB, Lee DH, Quan FS

Toxoplasma gondii is a ubiquitous protozoan parasite responsible for causing toxoplasmosis. Preventive measures for toxoplasmosis are currently lacking and as such, development of novel vaccines are of urgent need. In...
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Toxoplasma Encephalitis in a Patient with Human Immunodeficiency Virus Infection

Choi PK, Chung JY, Kang HG

Toxoplasma encephalitis is an opportunistic infection that may occur in immunocompromised or advanced HIV (Human Immunodeficiency Virus) patients and lead to serious complications in the CNS. We report a 44-year-old...
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Recent progress in microneme-based vaccines development against Toxoplasma gondii

Foroutan M, Zaki L, Ghaffarifar F

Toxoplasmosis is a cosmopolitan zoonotic disease, which infect several warm-blooded mammals. More than one-third of the human population are seropositive worldwide. Due to the high seroprevalence of Toxoplasma gondii infection...
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Immune Responses Induced by HSP60 DNA Vaccine against Toxoplasma gondii Infection in Kunming Mice

Li ZY, Lu J, Zhang NZ, Chen J, Zhu XQ

Toxoplasma gondii can infect all the vertebrates including human, and leads to serious toxoplasmosis and considerable veterinary problems. T. gondii heat shock protein 60 (HSP60) is associated with the activation...
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Modulated Gene Expression of Toxoplasma gondii Infected Retinal Pigment Epithelial Cell Line (ARPE-19) via PI3K/Akt or mTOR Signal Pathway

Zhou W, Quan JH, Gao FF, Ismail HA, Lee YH, Cha GH

Due to the critical location and physiological activities of the retinal pigment epithelial (RPE) cell, it is constantly subjected to contact with various infectious agents and inflammatory mediators. However, little...
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The Association between Suicide Attempts and Toxoplasma gondii Infection

Bak J, Shim SH, Kwon YJ, Lee HY, Kim JS, Yoon H, Lee YJ

OBJECTIVE: Chronic ‘latent’ infection by Toxoplasma gondii is common and most of the hosts have minimal symptoms or they are even asymptomatic. However, there are possible mechanisms by which T....
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Calcium-dependent protein kinases are potential targets for Toxoplasma gondii vaccine

Foroutan M, Ghaffarifar F

Toxoplasma gondii belongs to the Apicomplexa phylum that caused a widespread zoonotic infection in wide range of intermediate hosts. Over one-third of the world's population are latently infected with T....
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IL-12 and IL-23 Production in Toxoplasma gondii- or LPS-Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways

Ismail HA, Kang BH, Kim JS, Lee JH, Choi IW, Cha GH, Yuk JM, Lee YH

IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these...
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Comparison of Placenta PCR and Maternal Serology of Aborted Women for Detection of Toxoplasma gondii in Ardabil, Iran

Matin S, Shahbazi G, Namin ST, Moradpour , Feizi F, Piri-dogahe H

Primary maternal infection with toxoplasmosis during pregnancy is frequently associated with transplacental transmission of the parasite to the fetus. This study was conducted to test the utility of PCR assay...
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DNA Vaccines Encoding Toxoplasma gondii Cathepsin C 1 Induce Protection against Toxoplasmosis in Mice

Han Y, Zhou A, Lu G, Zhao G, Sha W, Wang L, Guo J, Zhou J, Zhou H, Cong H, He S

Toxoplasma gondii cathepsin C proteases (TgCPC1, 2, and 3) are important for the growth and survival of T. gondii. In the present study, B-cell and T-cell epitopes of TgCPC1 were...
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