- MicroSPECT and MicroPET Imaging of Small Animals for Drug Development
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Jang BS
- KMID: 2317809
- Toxicol Res.
- 2013 Mar;29(1):1-6.
The process of drug discovery and development requires substantial resources and time. The drug industry has tried to reduce costs by conducting appropriate animal studies together with molecular biological and... -
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- Antihyperglycemic and Antihyperlipidemic Effects of Fermented Rhynchosia nulubilis in Alloxan-induced Diabetic Rats
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Kim MJ, Ha BJ
- KMID: 2317811
- Toxicol Res.
- 2013 Mar;29(1):15-19.
Alloxan administration in rats is used as a model for non-insulin dependent diabetes mellitus (NIDDM). NIDDM is a multifactorial disease, characterized by hyperglycemia and lipoprotein abnormalities. In this study, we... -
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- Selective Effects of Curcumin on CdSe/ZnS Quantum-dot-induced Phototoxicity Using UVA Irradiation in Normal Human Lymphocytes and Leukemia Cells
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Goo S, Choi YJ, Lee Y, Lee S, Chung HW
- KMID: 2317814
- Toxicol Res.
- 2013 Mar;29(1):35-42.
Quantum dots (QDs) have received considerable attention due to their potential role in photosensitization during photodynamic therapy. Although QDS are attractive nanomaterials due to their novel and unique physicochemical properties,... -
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- Biodistribution of 99mTc Labeled Integrin Antagonist
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Jang BS, Park SH, Shin IS, Maeng JS, Paik CH
- KMID: 2317812
- Toxicol Res.
- 2013 Mar;29(1):21-25.
The selective targeting of an integrin alphavbeta3 receptor using radioligands may enable the assessment of angiogenesis and integrin alphavbeta3 receptor status in tumors. The aim of this research was to... -
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- Protective Effects of Houttuynia cordata Thunb. on Gentamicin-induced Oxidative Stress and Nephrotoxicity in Rats
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Kang C, Lee H, Hah DY, Heo JH, Kim CH, Kim E, Kim JS
- KMID: 2317817
- Toxicol Res.
- 2013 Mar;29(1):61-67.
Development of a therapy providing protection from, or reversing gentamicin-sulfate (GS)-induced oxidative stress and nephrotoxicity would be of great clinical significance. The present study was designed to investigate the protective... -
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- Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice
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Jung GY, Won SB, Kim J, Jeon S, Han A, Kwon YH
- KMID: 2317810
- Toxicol Res.
- 2013 Mar;29(1):7-14.
Betaine supplementation has been shown to alleviate altered glucose and lipid metabolism in mice fed a high-fat diet or a high-sucrose diet. We investigated the beneficial effects of betaine in... -
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- Evaluation of Oxidative DNA Damage Using an Alkaline Single Cell Gel Electrophoresis (SCGE) Comet Assay, and the Protective Effects of N-Acetylcysteine Amide on Zearalenone-induced Cytotoxicity in Chang Liver Cells
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Kang C, Lee H, Yoo YS, Hah DY, Kim CH, Kim E, Kim JS
- KMID: 2317815
- Toxicol Res.
- 2013 Mar;29(1):43-52.
Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin produced by several species of Fusarium that are found in cereals and agricultural products. ZEN has been implicated in mycotoxicosis in farm animals... -
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- Embryotoxicity and Toxicokinetics of the Antimalarial Artesunate in Rats
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Chung MK, Yu WJ, Lee JS, Lee JH
- KMID: 2317813
- Toxicol Res.
- 2013 Mar;29(1):27-34.
This study was conducted to investigate the potential embryo-fetal toxicity and toxicokinetics of the antimalarial agent artesunate (ARTS) in Sprague-Dawley rats. Pregnant rats were administered ARTS daily from gestational day... -
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- Milk Transfer and Toxicokinetics of Valproic Acid in Lactating Cynomolgus Monkeys
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Lee JH, Yu WJ, Jeong EJ, Chung MK
- KMID: 2317816
- Toxicol Res.
- 2013 Mar;29(1):53-60.
Studies on milk transfer of drugs in non-human primates (NHPs) are among the crucial components in the assessment of peri- and postnatal toxicity because of the similarity between NHPs and... -
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- Health Risks to Children and Adults Residing in Riverine Environments where Surficial Sediments Contain Metals Generated by Active Gold Mining in Ghana
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Armah FA, Gyeabour E
- KMID: 2317818
- Toxicol Res.
- 2013 Mar;29(1):69-79.
The purpose of this study was to investigate the current status of metal pollution in the sediment from rivers, lakes, and streams in active gold mining districts in Ghana. Two... -
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