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Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs

Kim MS, Ham SH, Kim JH, Shin JE, Oh J, Kim TW, Yun HI, Lim JH, Jang BS, Cho JH

  • KMID: 1432310
  • Toxicol Res.
  • 2012 Dec;28(4):263-268.
The aim of this study was to investigate the acute oral toxicity of fermented Scutellariae Radix (JKTMHGu-100) in rats and dogs. JKTM-HGu-100 was orally administered at a dose of 2,000...
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Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema

Ahn MY, Han JW, Yoon HJ, Hwang JS, Young YE

  • KMID: 1432308
  • Toxicol Res.
  • 2012 Dec;28(4):249-253.
In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of...
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Nasal and Pulmonary Toxicity of Titanium Dioxide Nanoparticles in Rats

Kwon S, Yang YS, Yang HS, Lee J, Kang MS, Lee BS, Lee K, Song CW

  • KMID: 1432304
  • Toxicol Res.
  • 2012 Dec;28(4):217-224.
In recent decades, titanium dioxide (TiO2) nanoparticles have been used in various applications, including paints, coatings, and food. However, data are lacking on the toxicological aspects associated with their use....
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Biodistribution of 99mTc Tricarbonyl Glycine Oligomers

Jang BS, Lee JS, Rho JK, Park SH

  • KMID: 1432306
  • Toxicol Res.
  • 2012 Dec;28(4):235-240.
99mTc tricarbonyl glycine monomers, trimers, and pentamers were synthesized and evaluated for their radiolabeling and in vivo distribution characteristics. We synthesized a 99mTc-tricarbonyl precursor with a low oxidation state (I)....
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The Effects of Hazardous Chemical Exposure on Cardiovascular Disease in Chemical Products Manufacturing Workers

Kim KW, Won YL, Ko KS, Heo KH, Chung YH

  • KMID: 1432311
  • Toxicol Res.
  • 2012 Dec;28(4):269-277.
The purpose of this study was to understand the mechanism of cardiovascular disease (CVD) caused by exposure to hazardous chemicals. We investigated changes in the symptoms of metabolic syndrome, which...
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A 6-Week Oral Toxicity Study of Oral Cholera Vaccine in Sprague-Dawley Rats

Baek YO, Choi SK, Shin SH, Koo KH, Choi HY, Cha SB, Li YC, Yoo HJ, Lee JY, Kil KH, Kim HS, Kang MS, Kang BH, Kim KH, Bae JS

  • KMID: 1432305
  • Toxicol Res.
  • 2012 Dec;28(4):225-233.
The present study was carried out to examine the toxicity and target organs of oral cholera vaccine (OCV) after repeated oral administration in Sprague-Dawley rats for 6 weeks (3 administrations,...
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The Chloroform Fraction of Carpinus tschonoskii Leaves Inhibits the Production of Inflammatory Mediators in HaCaT Keratinocytes and RAW264.7 Macrophages

Kang GJ, Kang NJ, Han SC, Koo DH, Kang HK, Yoo BS, Yoo ES

  • KMID: 1432309
  • Toxicol Res.
  • 2012 Dec;28(4):255-262.
Inflammation is the immune system's response to infection and injury-related disorders, and is related to pro-inflammatory factors (NO, PGE2, cytokines, etc.) produced by inflammatory cells. Atopic dermatitis (AD) is a...
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Biocompatible Dispersion Methods for Carbon Black

Kim H, Park K, Lee MY

  • KMID: 1432303
  • Toxicol Res.
  • 2012 Dec;28(4):209-216.
The biological activity of particles is largely dependent on their size in biological systems. Dispersion in the aqueous phase has been both a critical impediment to and a prerequisite for...
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Effect of Microalgal Extracts of Tetraselmis suecica against UVB-Induced Photoaging in Human Skin Fibroblasts

Jo WS, Yang KM, Park HS, Kim GY, Nam BH, Jeong MH, Choi YJ

  • KMID: 1432307
  • Toxicol Res.
  • 2012 Dec;28(4):241-248.
Exposure of cells to ultraviolet B (UVB) radiation can induce production of free radicals and reactive oxygen species (ROS), which damage cellular components. In addition, these agents can stimulate the...
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Zearalenone Affects Immune-Related Parameters in Lymphoid Organs and Serum of Rats Vaccinated with Porcine Parvovirus Vaccine

Choi BK, Cho JH, Jeong SH, Shin HS, Son SW, Yeo YK, Kang HG

  • KMID: 1432312
  • Toxicol Res.
  • 2012 Dec;28(4):279-288.
Rats were administered zearalenone (ZEA) via gavage at dosages of 0, 1, 5, and 30 mg/kg for 36 days. On treatment day 8, inactivated porcine parvovirus vaccine (Vac) was injected...
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