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Anti-Inflammatory Effect for Atherosclerosis Progression by Sodium-Glucose Cotransporter 2 (SGLT-2) Inhibitor in a Normoglycemic Rabbit Model

Lee SG, Lee SJ, Lee JJ, Kim JS, Lee OH, Kim CK, Kim D, Lee YH, Oh J, Park S, Jeon OH, Hong SJ, Ahn CM, Kim BK, Ko YG, Choi D, Hong MK, Jang Y

BACKGROUND AND OBJECTIVES: We sought to investigate an anti-atherosclerotic and anti-inflammatory effect of sodium-glucose cotransporter-2 (SGLT-2) inhibitors in normoglycemic atherosclerotic rabbit model. METHODS: Male New Zealand white rabbits (n=26) were fed...
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Downregulation of IL-18 Expression in the Gut by Metformin-induced Gut Microbiota Modulation

Lee H, Kim J, An J, Lee S, Choi D, Kong H, Song Y, Park IH, Lee CK, Kim K

IL-18 is a crucial pro-inflammatory cytokine that mediates chronic intestinal inflammation. Metformin, an anti-diabetic drug, was reported to have ameliorative effects on inflammatory bowel disease. Recently, the mechanism of action...
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Three Fibrotic Conditions Treated with 5% Topical Imiquimod Cream as an Antifibrotic Agent

Cho YR, Kim HJ, Seo JW, Kim TH, Kim KH

  • KMID: 2451589
  • Korean J Dermatol.
  • 2019 Jun;57(5):265-269.
Imiquimod, a toll-like receptor agonist, is a topical immunomodulator that induces the production of several cytokines including interferon-alpha, which shows antifibrotic properties. We hypothesized that the antifibrotic effect of imiquimod...
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Analgesic Effect of Toll-like Receptor 4 Antagonistic Peptide 2 on Mechanical Allodynia Induced with Spinal Nerve Ligation in Rats

Yin Y, Park H, Lee SY, Lee WH, Song HJ, Kim J, Kim DW, Hong J

Neuroinflammation is one of the key mechanisms of neuropathic pain, which is primarily mediated by the Toll-like receptor 4 (TLR4) signaling pathways in microglia. Therefore, TLR4 may be a reasonable...
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Effector Pathways of Toll-like Receptor-inducible Innate Immune Responses in Macrophages

Jo EK, Suh HW, Park JK

Toll-like receptors (TLR) are well-characterized pattern recognition receptors that can recognize and respond to diverse pathogen-associated or danger-associated molecular patterns during infection. TLR signaling in macrophages triggers in the intracellular...
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Mechanisms and therapeutic targets of ischemic acute kidney injury

Han SJ, Lee HT

Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem without effective therapy and is a significant and frequent cause of morbidity and mortality during...
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Human Immunity Against Campylobacter Infection

Hameed A

Campylobacter is a worldwide foodborne pathogen, associated with human gastroenteritis. The efficient translocation of Campylobacter and its ability to secrete toxins into host cells are the 2 key features of...
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Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies

Kwon S, Iba M, Masliah E, Kim C

Synucleinopathies are neurodegenerative disorders characterized by the progressive accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In this review,...
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Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation

Ayala-Cuellar AP, Kang JH, Jeung EB, Choi KC

Mesenchymal stem cells are classified as multipotent stem cells, due to their capability to transdifferentiate into various lineages that develop from mesoderm. Their popular appeal as cell-based therapy was initially...
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Diallyl Trisulfide Suppresses the Production of Lipopolysaccharide-induced Inflammatory Mediators in BV2 Microglia by Decreasing the NF-κB Pathway Activity Associated With Toll-like Receptor 4 and CXCL12/CXCR4 Pathway Blockade

Lee HH, Jeong JW, Hong SH, Park C, Kim BW, Choi YH

BACKGROUND: Diallyl trisulfide (DATS), a garlic-derived organosulfuric compound, has been documented for potential anti-inflammatory effects. However, the mechanism in microglia remains unknown. In this study, we investigated the anti-inflammatory effects...
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Development of Vitiligo-Like Depigmentation after Treatment of Lentigo Maligna Melanoma with 5% Imiquimod Cream

Kim NH, Lee JB, Yun SJ

A 69-year-old man presented with a black irregular patch on his left cheek. Skin biopsy revealed lentigo maligna melanoma in situ. He was treated via partial excision of the melanoma,...
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Potential Mechanisms Underlying the Increased Excitability of the Bladder Afferent Pathways in Interstitial Cystitis/Bladder Pain Syndrome

Kim DS

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic debilitating disorder associated with lower urinary tract symptoms, including frequency, urgency, and suprapubic pain, which inconveniences the patients and seriously impairs their...
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Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation

Lu TF, Yang TH, Zhong CP, Shen C, Lin WW, Gu GX, Xia Q, Xu N

Ischemia-reperfusion injury (IRI) is a major complication in liver transplantation (LT) and it is closely related to the recovery of grafts' function. Researches has verified that both innate and adaptive...
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Immune Characterization of Bone Marrow-Derived Models of Mucosal and Connective Tissue Mast Cells

Benedé S, Cody E, Agashe C, Berin MC

PURPOSE: It is well appreciated that mast cells (MCs) demonstrate tissue-specific imprinting, with different biochemical and functional properties between connective tissue MCs (CTMCs) and mucosal MCs (MMCs). Although in vitro...
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Toll-like receptor 2 promotes neurogenesis from the dentate gyrus after photothrombotic cerebral ischemia in mice

Seong KJ, Kim HJ, Cai B, Kook MS, Jung JY, Kim WJ

The subgranular zone (SGZ) of hippocampal dentate gyrus (HDG) is a primary site of adult neurogenesis. Toll-like receptors (TLRs), are involved in neural system development of Drosophila and innate immune...
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Variable localization of Toll-like receptors in human fallopian tube epithelial cells

Amjadi F, Zandieh Z, Salehi E, Jafari R, Ghasemi N, Aflatoonian A, Fazeli A, Aflatoonian R

OBJECTIVE: To determine the localization, expression, and function of Toll-like receptors (TLRs) in fallopian tube epithelial cells. METHODS: The localization of TLRs in fallopian tube epithelial cells was investigated by immunostaining....
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Toll-like Receptor 1/2 Agonist Pam3CSK4 Suppresses Lipopolysaccharide-driven IgG1 Production while Enhancing IgG2a Production by B Cells

Lee SH, Park SR

Interaction between pathogen-associated molecular patterns and pattern recognition receptors triggers innate and adaptive immune responses. Several studies have reported that toll-like receptors (TLRs) are involved in B cell proliferation, differentiation,...
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Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells

Zandieh Z, Amjadi F, Vakilian H, Aflatoonian K, Amirchaghmaghi E, Fazeli A, Aflatoonian R

OBJECTIVE: The fallopian tubes play a critical role in the early events of fertilization. The rapid innate immune defense is an important part of the fallopian tubes. Toll-like receptor 3...
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Expression of Toll-like Receptors, Pro-, and Anti-inflammatory Cytokines in Relation to Gut Microbiota in Irritable Bowel Syndrome: The Evidence for Its Micro-organic Basis

Shukla R, Ghoshal U, Ranjan P, Ghoshal UC

  • KMID: 2422853
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):628-642.
  • doi: 10.5056/jnm18130
BACKGROUND/AIMS: A Subset of patients with irritable bowel syndrome (IBS) may have mild inflammation due to immune activation. Toll-like receptors (TLRs) and cytokines may cause intestinal inflammation. We studied their...
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Do Toll-like Receptors Play a New Role as a Biomarker of Irritable Bowel Syndrome?

Kim HJ

  • KMID: 2422841
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):510-511.
  • doi: 10.5056/jnm18153
No abstract available.
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