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Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats

Lee B, Yeom M, Shim I, Lee H, Hahm DH

Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but...
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Analgesic Effect of Toll-like Receptor 4 Antagonistic Peptide 2 on Mechanical Allodynia Induced with Spinal Nerve Ligation in Rats

Yin Y, Park H, Lee SY, Lee WH, Song HJ, Kim J, Kim DW, Hong J

Neuroinflammation is one of the key mechanisms of neuropathic pain, which is primarily mediated by the Toll-like receptor 4 (TLR4) signaling pathways in microglia. Therefore, TLR4 may be a reasonable...
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Potential Roles of Innate Immune Chemokine and Cytokine Network on Lipopolysaccharide-Based Therapeutic Approach in Ovarian Cancer

Ignacio RM, Lee ES, Son DS

Ovarian cancer (OC), the deadliest gynecological cancer, results in poor overall survival, urgently requiring a novel therapeutic approach. As cumulative exposures to endotoxins decreased OC risk epidemiologically, we evaluated if...
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p62 Negatively Regulates TLR4 Signaling via Functional Regulation of the TRAF6-ECSIT Complex

Kim MJ, Min Y, Kwon J, Son J, Im JS, Shin J, Lee KY

Sequestosome 1 (SQSTM1, p62), a ubiquitin binding protein, plays a role in cell signaling, oxidative stress, and autophagy. However, its functional role in inflammatory signaling is controversial. Recent studies have...
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Mycobacterium tuberculosis ESAT6 Drives the Activation and Maturation of Bone Marrow-Derived Dendritic Cells via TLR4-Mediated Signaling

Jang AR, Kim G, Hong JJ, Kang SM, Shin SJ, Park JH

6-kDa early secretory antigenic target (ESAT6), a virulent factor of Mycobacterium tuberculosis, is involved in immune regulation. However, the underlying mechanism behind the activation and maturation of dendritic cells (DCs)...
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MiR-590 Inhibits Endothelial Cell Apoptosis by Inactivating the TLR4/NF-κB Pathway in Atherosclerosis

Yang L, Gao C

PURPOSE: Previous study has well documented the anti-apoptotic effects of miR-590 on oxidized low-density lipoprotein (ox-LDL)-treated endothelial cells (ECs). However, the mechanism underlying the anti-apoptotic effects of miR-590 in ox-LDL-treated...
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Diallyl Trisulfide Suppresses the Production of Lipopolysaccharide-induced Inflammatory Mediators in BV2 Microglia by Decreasing the NF-κB Pathway Activity Associated With Toll-like Receptor 4 and CXCL12/CXCR4 Pathway Blockade

Lee HH, Jeong JW, Hong SH, Park C, Kim BW, Choi YH

BACKGROUND: Diallyl trisulfide (DATS), a garlic-derived organosulfuric compound, has been documented for potential anti-inflammatory effects. However, the mechanism in microglia remains unknown. In this study, we investigated the anti-inflammatory effects...
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Adenine attenuates lipopolysaccharide-induced inflammatory reactions

Silwal P, Lim K, Heo JY, Park JI, Namgung U, Park SK

A nucleobase adenine is a fundamental component of nucleic acids and adenine nucleotides. Various biological roles of adenine have been discovered. It is not produced from degradation of adenine nucleotides...
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Comparison of the effect of three licorice varieties on cognitive improvement via an amelioration of neuroinflammation in lipopolysaccharide-induced mice

Cho MJ, Kim JH, Park CH, Lee AY, Shin YS, Lee JH, Park CG, Cho EJ

BACKGROUND/OBJECTIVES: Neuroinflammation plays critical role in neurodegenerative disorders, such as Alzheimer's disease (AD). We investigated the effect of three licorice varieties, Glycyrhiza uralensis, G. glabra, and Shinwongam (SW) on a...
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Grape seed proanthocyanidin extract ameliorates murine autoimmune arthritis through regulation of TLR4/MyD88/NF-κB signaling pathway

Kim SH, Bang J, Son CN, Baek WK, Kim JM

BACKGROUND/AIMS: Grape seed proanthocyanidin extract (GSPE) has been reported to have a beneficial effect on regulating inf lammation. However, the anti-inflammatory mechanism of GSPE remains unclear. The aim of this...
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LPS-stimulated Macrophage Activation Affects Endothelial Dysfunction

Baek N, Sim S, Heo KS

Intestinal microbiota is involved in the atherosclerotic process by development of an atheromatous core with foam cells in carotid arteries. It has reported that lipopolysaccharide (LPS) from Escherichia coli localizes...
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Udenafil, a Phosphodiesterase 5 Inhibitor, Reduces Body Weight in High-Fat-Fed Mice

Ryu SY, Choi YJ, Park SY, Kim JY, Kim YD, Kim YW

PURPOSE: High-fat (HF) feeding induces hypothalamic leptin resistance via the activation of toll-like receptor 4 (TLR4). TLR4 deficiency confers resistance to diet-induced obesity. Udenafil, an anti-impotence drug, inhibits TLR4 in...
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Changes in serum levels of lipopolysaccharides and CD26 in patients with Crohn's disease

Magro DO, Kotze PG, Martinez C, Camargo MG, Guadagnini D, Calixto AR, Vasques AC, Ayrizono M, Geloneze B, Pareja JC, Saad MJ, Coy CS

BACKGROUND/AIMS: Lipopolysaccharide (LPS) is a molecule formed by lipids and polysaccharides and is the major cell wall component of gram-negative bacteria. High LPS levels are known to block CD26 expression...
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Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits

Bárcena-Varela S, Martínez-de-Tejada G, Martin L, Schuerholz T, Gil-Royo A, Fukuoka S, Goldmann T, Droemann D, Correa W, Gutsmann T, Brandenburg K, Heinbockel L

Sepsis, which is induced by severe bacterial infections, is a major cause of death worldwide, and therapies combating the disease are urgently needed. Because many drugs have failed in clinical...
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Asian Sand Dust Up-Regulates MUC4 Expression in Human Upper Airway Epithelial Cells

Park CH, Song YS, Bae CH, Choi YS, Song SY, Shin KC, Jin HJ, Kim YD

BACKGROUND AND OBJECTIVES: Asian sand dust (ASD) is a meteorological phenomenon that occurs in spring time in Korea. ASD is composed of various organic and inorganic materials, which induce airway...
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The inflammatory response of neutrophils in an in vitro model that approximates the postcardiac arrest state

Cho YD, Park SJ, Choi SH, Yoon YH, Kim JY, Lee SW, Lim CS

PURPOSE: Postcardiac arrest syndrome (PCAS) shares many features with sepsis including plasma cytokine elevation with dysregulation of cytokine production, and the presence of endotoxin in plasma. PCAS is closely related...
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The optimal duration of ischemic preconditioning for renal ischemia-reperfusion injury in mice

Choi HS, Hwang JK, Kim JG, Hwang HS, Lee SJ, Chang YK, Kim JI, Moon IS

PURPOSE: The aim of the present study was to investigate the protective effects of ischemic preconditioning for different periods of time and to elucidate the optimal safe ischemic preconditioning time...
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New Era of Post Urinary Tract Infection Pain Syndrome

Lee KW, Kim YH

Urinary tract infection (UTI) in most cases is accompanied by pain. However, in some cases, including asymptomatic bacteriuria (ASB), pain is absent and thus, cannot be characterized. A study with...
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Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System

Leem E, Jeong KH, Won SY, Shin WH, Kim SR

Although accumulating evidence suggests that microglia-mediated neuroinflammation may be crucial for the initiation and progression of Parkinson's disease (PD), and that the control of neuroinflammation may be a useful strategy...
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High-fat Diet Accelerates Intestinal Tumorigenesis Through Disrupting Intestinal Cell Membrane Integrity

Park MY, Kim MY, Seo YR, Kim JS, Sung MK

BACKGROUND: Excess energy supply induces chronic low-grade inflammation in association with oxidative stress in various tissues including intestinal epithelium. The objective of this study was to investigate the effect of...
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