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Biological Interaction Between Human Gingival Fibroblasts and Vascular Endothelial Cells for Angiogenesis: A Co-culture Perspective

Allah NU, Berahim Z, Ahmad A, Kannan TP

Advancement in cell culture protocols, multidisciplinary research approach, and the need of clinical implication to reconstruct damaged or diseased tissues has led to the establishment of three-dimensional (3D) test systems...
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Fabrication and Characterization of Polyphosphazene/Calcium Phosphate Scaffolds Containing Chitosan Microspheres for Sustained Release of Bone Morphogenetic Protein 2 in Bone Tissue Engineering

Sobhani A, Rafienia M, Ahmadian M, Naimi-Jamal MR

Bone morphogenetic protein 2 has a major role in promoting bone regeneration in tissue engineering scaffolds. Growth factor release rate is a remaining crucial problem in these systems. The aim...
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Graphene as an Enabling Strategy for Dental Implant and Tissue Regeneration

Park C, Park S, Lee D, Choi KS, Lim HP, Kim J

Graphene-based approaches have been influential in the design and manipulation of dental implants and tissue regeneration to overcome the problems associated with traditional titanium-based dental implants, such as their low...
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Atelocollagen-based Hydrogels Crosslinked with Oxidised Polysaccharides as Cell Encapsulation Matrix for Engineered Bioactive Stromal Tissue

Luca A, Butnaru M, Maier SS, Knieling L, Bredetean , Verestiuc , Dimitriu D, Popa M

Tissue stroma is responsible for extracellular matrix (ECM) formation and secretion of factors that coordinate the behaviour of the surrounding cells through the microenvironment created. It's inability to spontaneously regenerate...
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Chemokine Receptors Expression in MSCs: Comparative Analysis in Different Sources and Passages

Heirani-Tabasi A, Toosi S, Mirahmadi , Mishan MA, Bidkhori H, Bahrami AR, Behravan J, Naderi-Meshkin H

MSC-based therapy is providing a cure for degenerative diseases with unmet medical need and usually iliac crest bone marrow (ICBM) are being applied in clinics. Alternative sources, including adipose tissue...
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Simple Maturation of Direct-Converted Hepatocytes Derived from Fibroblasts

Cho YD, Yoon S, Kang K, Kim Y, Lee SB, Seo D, Ryu K, Jeong J, Choi D

Target cells differentiation techniques from stem cells are developed rapidly. Recently, direct conversion techniques are introduced in various categories. Unlike pluripotent stem cells, this technique enables direct differentiation into the...
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Effect of Thermoresponsive Poly(L-lactic acid)-poly (ethylene glycol) Gel Injection on Left Ventricular Remodeling in a Rat Myocardial Infarction Model

Somekawa S, Mahara A, Masutani K, Kimura Y, Urakawa H, Yamaoka T

Some gel types have been reported to prevent left ventricular (LV) remodeling in myocardial infarction (MI) animal models. In this study, we tested biodegradable thermoresponsive gels. Poly(L-lactic acid)-poly(ethylene glycol) (PLLA-PEG)...
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Differentiation Potential of Breast Milk-Derived Mesenchymal Stem Cells into Hepatocyte-Like Cells

Sani M, Ebrahimi S, Aleahmad F, Salmannejad M, Hosseini S, Mazarei G, Talaei-Khozani T

Human breast milk stem cells (hBSCs) contain a population of cells with the ability to differentiate into various cell lineages for cell therapy applications. The current study examined the differentiation...
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Micronized Cross-Linked Human Acellular Dermal Matrices: An Effective Scaffold for Collagen Synthesis and Promising Material for Tissue Augmentation

Park TH, Choi WY, Lee JH, Lee WJ

Micronized cross-linked human acellular dermal matrices (ADMs) contain the extracellular components necessary for cell integration and tissue remodeling, and have high tensile strength and durability. We hypothesized that such material...
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Platelet Rich Plasma and Culture Configuration Affect the Matrix Forming Phenotype of Bone Marrow Stromal Cells

Infante A, Rubio-Azpeitia E, Sa´nchez , Alberdi R, Rodriguez , Andia I

We aim to examine the influence of platelet rich plasma (PRP) and spatial cues in cartilage/bone matrix forming proteins, and to evaluate the mitotic and chemotactic potential of PRP on...
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Profile of MicroRNA Expression in Endometrial Cell during In Vitro Culture According to Progesterone Concentration

Kim YJ, Kim YY, Kim DW, Joo JK, Kim H, Ku SY

Artificial uterus using endometrium implant can be a novel treatment strategy for infertile women with refractory endometrial dysfunction. At early pregnancy, the function of uterine endometrial cells for the communication...
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Serial Analysis of Tracheal Restenosis After 3D-Printed Scaffold Implantation: Recruited Inflammatory Cells and Associated Tissue Changes

Ahn HJ, Khalmuratova R, Park SA, Chung EJ, Shin HW, Kwon SK

Tracheal restenosis is a major obstacle to successful tracheal replacement, and remains the greatest challenge in tracheal regeneration. However, there have been no detailed investigations of restenosis. The present study...
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Enrichment and In Vitro Culture of Spermatogonial Stem Cells from Pre-Pubertal Monkey Testes

Kim YH, Kang HG, Kim BJ, Jung SE, Karmakar P, Kim SM, Hwang S, Ryu BY

Spermatogonial stem cells (SSCs) are essential for spermatogenesis throughout the lifespan of the male. However, the rarity of SSCs has raised the need for an efficient selection method, but little...
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Hypoxia Enhances Cell Properties of Human Mesenchymal Stem Cells

Kwon SY, Chun SY, Ha YS, Kim DH, Kim J, Song PH, Kim HT, Yoo ES, Kim BS, Kwon TG

Atmospheric (in vitro) oxygen pressure is around 150 mm Hg (20% O₂), whereas physiologic (in vivo) oxygen pressure ranges between 5 and 50 mm Hg (0.7–7% O₂). The normoxic environment...
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