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Insight into Microenvironment Remodeling in Pancreatic Endocrine Tissue Engineering: Biological and Biomaterial Approaches

Kaviani M, Azarpira N

The treatment of diabetes mellitus, as a chronic and complicated disease, is a valuable purpose. Islet transplantation can provide metabolic stability and insulin independence in type 1 diabetes patients. Diet...
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Alginate-Hyaluronic Acid-Collagen Composite Hydrogel Favorable for the Culture of Chondrocytes and Their Phenotype Maintenance

Mahapatra , Jin GZ, Kim HW

Articular cartilage has limited regeneration capacity, thus significant challenge has been made to restore the functions. The development of hydrogels that can encapsulate and multiply cells, and then effectively maintain...
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Microengineered Platforms for Co-Cultured Mesenchymal Stem Cells towards Vascularized Bone Tissue Engineering

Park H, Lim DJ, Sung M, Lee SH, Na D, Park H

Bone defects are common disease requiring thorough treatments since the bone is a complex vascularized tissue that is composed of multiple cell types embedded within an intricate extracellular matrix (ECM)....
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Chitosan-Poly(Vinyl Alcohol) Nanofibers by Free Surface Electrospinning for Tissue Engineering Applications

Agrawal P, Pramanik K

Deformities in tissues and organs can be treated by using tissue engineering approach offering the development of biologically functionalized scaffolds from a variety of polymer blends which mimic the extracellular...
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Efficient Biomaterials for Tissue Engineering of Female Reproductive Organs

Tamadon A, Park KH, Kim YY, Kang BC, Ku SY

Current investigations on the bioengineering of female reproductive tissues have created new hopes for the women suffering from reproductive organ failure including congenital anomaly of the female reproductive tract or...
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Prefabrication of Axially Vascularized Bone by Combining β-Tricalciumphosphate, Arteriovenous Loop, and Cell Sheet Technique

Ma D, Ren L, Cao Z, Li J, Cao J, Tian W, Yao H

The repair of bone defects poses a great challenge for reconstructive surgeons. Although the development of tissue engineering has exhibited promise in replacing damaged bone, the fabrication of large constructs...
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Bioreactor Conditioning of Valve Scaffolds Seeded Internally with Adult Stem Cells

Kennamer A, Sierad L, Pascal R, Rierson N, Albers C, Harpa M, Cotoi O, Harceaga L, Olah P, Terezia P, Simionescu A, Simionescu D

The goal of this study was to test the hypothesis that stem cells, as a response to valve-specific extracellular matrix “niches” and mechanical stimuli, would differentiate into valvular interstitial cells...
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Electrospun Fibrous Silk Fibroin/Poly(L-Lactic Acid) Scaffold for Cartilage Tissue Engineering

Liu W, Li Z, Zheng L, Zhang X, Liu P, Yang T, Han B

For successful tissue engineering of articular cartilage, a scaffold with mechanical properties that match those of natural cartilage as closely as possible is needed. In the present study, we prepared...
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Efficient Induction of Neural Precursor Cells from Fibroblasts Using Stromal Cell-Derived Inducing Activity

Lim MS, Kim SM, Lee EH, Park CH

The direct lineage conversion of fibroblasts into neuronal or neural precursor cells (NPCs) has become a hot issue in recent years as an attractive approach in the field of stem...
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Hypoxia Enhances Osteogenic Differentiation in Retinoic Acid-Treated Murine-Induced Pluripotent Stem Cells

Manokawinchoke J, Osathanon , Egusa H, Pavasant P

Hypoxic condition influences biological responses in various cell types. However, a hypoxic regulating osteogenic differentiation remains controversy. Here, an influence of short-term culture in hypoxic condition on osteogenic marker gene...
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Comparative Study of Poly(L-Lactic Acid) Scaffolds Coated with Chitosan Nanoparticles Prepared via Ultrasonication and Ionic Gelation Techniques

Salehi M, Naseri-Nosar M, Azami M, Nodooshan , Arish J

In this study, an attempt was made to develop bi-functional constructs serving both as scaffolds and potential delivery systems for application in neural tissue engineering. The constructs were prepared in...
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The Therapeutic Potential of Stem Cells and Progenitor Cells for the Treatment of Parkinson's Disease

Liau MT, Amini F, Ramasamy T

Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is usually seen in those above 50 years old. Current medical treatments only provide symptomatic relief but cannot cure...
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Differentiation of Rat Dermal Mesenchymal Cells and Calcification in Three-Dimensional Cultures

Suyama T, Hatta M, Hata S, Ishikawa H, Yamazaki J

Three-dimensional (3D) cultures are known to promote cell differentiation. Previously, we investigated the differentiation of rat dermal fibroblasts to α-smooth muscle actin (α-SMA)-positive myofibroblasts through transforming growth factor (TGF)-β production...
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Platelet-Derived Growth Factor-BB-Immobilized Asymmetrically Porous Membrane for Enhanced Rotator Cuff Tendon Healing

Min HK, Kwon OS, Oh SH, Lee JH

Rotator cuff tear is a common musculoskeletal disease that often requires surgical repair. Despite of recent advances in surgical techniques, the re-tear rate of the rotator cuff tendon is very...
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Vascular Endothelial Growth Factor Enhances Axonal Outgrowth in Organotypic Spinal Cord Slices via Vascular Endothelial Growth Factor Receptor 1 and 2

Park HW, Jeon HJ, Chang MS

Enhancing adult nerve regeneration is a potential therapeutic strategy for treating spinal cord injury. Vascular endothelial growth factor (VEGF) is a major contributor to angiogenesis, which can reduce the spinal...
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Pigmentation Effect of Electromagnetic Fields at Various Intensities to Melanocytes

Cho SE, Kim YM, Kang KH, Kim SC, Park JK, Seo YK

Melanogenesis is the biological process that results in the synthesis of skin pigment of melanin and it has various functions in living systems and is synthesized by the melanosome within...
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Functional Recovery Not Correlated with Axon Regeneration through Olfactory Ensheathing Cell-Seeded Scaffolds in a Model of Acute Spinal Cord Injury

Altinova H, Möllers S, Deumens R, Gerardo-Nava J, Führmann , van Neerven SGA, Bozkurt A, Mueller CA, Hoff HJ, Heschel I, Weis J, Brook GA

The implantation of bioengineered scaffolds into lesion-induced gaps of the spinal cord is a promising strategy for promoting functional tissue repair because it can be combined with other intervention strategies....
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